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Chemical Structure| 244780-32-3 Chemical Structure| 244780-32-3

Structure of 244780-32-3

Chemical Structure| 244780-32-3

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Product Details of [ 244780-32-3 ]

CAS No. :244780-32-3
Formula : C13H19N3O4
M.W : 281.31
SMILES Code : O=C(OC(C)(C)C)NC1=C(C(N(OC)C)=O)C=NC=C1
MDL No. :MFCD24474436

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Application In Synthesis of [ 244780-32-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 244780-32-3 ]

[ 244780-32-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6638-79-5 ]
  • [ 171178-34-0 ]
  • [ 244780-32-3 ]
YieldReaction ConditionsOperation in experiment
42% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20℃; for 16h;Inert atmosphere; To a stirred solution of BM (5.1 g, 0.02 mol) in DMF (10 mL) under inert atmosphere were added EDCI HC1 (6.14 g, 0.03 mol), HOBt (4.33 g, 0.03 mol), diisopropylethyl amine (5.53 g, 0.04 mol) and Nu,Omicron-dimethylhydroxylamine hydrochloride (4.18 g, 0.04 mol) at 0 C. The reaction was warmed to RT and stirred for 16 h. After complete consumption of the starting material, the reaction mixture was diluted with water (40 mL) and the compound was extracted with diethyl ether (3x40 mL). The combined organic extracts were washed with water (40 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The crude was purified through column chromatography eluting with 3% MeOH/CH2Cl2 to afford BN (2.5 g, 42%) as a yellow solid. *H NMR (400 MHz, CDC13): delta 8.98 (br s, 1H), 8.74 (s, 1H), 8.47 (d, / = 15.0 Hz, 1H), 8.25 (d, / = 15.0 Hz, 1H), 3.58 (s, 3H), 3.41 (s, 3H), 1.52 (s, 9H).
 

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