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Chemical Structure| 24786-54-7 Chemical Structure| 24786-54-7

Structure of 24786-54-7

Chemical Structure| 24786-54-7

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Product Details of [ 24786-54-7 ]

CAS No. :24786-54-7
Formula : C8H8BrN3
M.W : 226.07
SMILES Code : NC1=NC2=CC=C(Br)C=C2N1C
MDL No. :MFCD21194033

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Application In Synthesis of [ 24786-54-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24786-54-7 ]

[ 24786-54-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 506-68-3 ]
  • [ 337915-79-4 ]
  • [ 24786-54-7 ]
YieldReaction ConditionsOperation in experiment
85% In methanol; at 20℃; for 1h; Step C6-bromo- 1 -methyl- 1 H-benzimidazol-2-[00304] A solution of (2-amino-5-bromophenyl)methylamine (992 mg, 4.93 mmol) inMeOH (10 mL) was treated with cyanogen bromine (1045 mg, 9.87 mmol). The reaction mixture was maintained at room temperature for 1 h, then partitioned between EtOAc (100 mL), a sat. NaHC03 solution (100 mL) and water (20 mL). The organic layer was washed with a sat. NaCI solution, dried (Na2S04) and concentrated. The residue was triturated using CH2CI2 to obtain 6- bromo-1-methyl-1 H-benzimidazol-2-amine (952 mg, 4.21 mmol, 85 % yield) as a beige solid:.1H NMR (400 MHz, DMSO-cfe) delta ppm 3.48 (s, 3 H) 6.57 (s, 2 H) 7.04 (d, J=0.98 Hz, 2 H) 7.30 - 7.38 (m, 1 H) ES LC-MS m/z =226.1 (Br79, M+H)+; ES LC-MS m/z =228.1 (Br81, M+H)+.
 

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