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[ CAS No. 2493-04-1 ]

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Chemical Structure| 2493-04-1
Chemical Structure| 2493-04-1
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CAS No. :2493-04-1 MDL No. :MFCD00272267
Formula : C5H5NO4 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :143.10 g/mol Pubchem ID :-
Synonyms :

Safety of [ 2493-04-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H312-H315-H319-H332-H335 Packing Group:N/A
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Application In Synthesis of [ 2493-04-1 ]

  • Upstream synthesis route of [ 2493-04-1 ]
  • Downstream synthetic route of [ 2493-04-1 ]

[ 2493-04-1 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 2493-04-1 ]
  • [ 698-63-5 ]
YieldReaction ConditionsOperation in experiment
90% With manganese(IV) oxide In dichloromethane at 20℃; for 12 h; The compound 4 (10 g, 0.07 µM) dissolved in 150 ml dichloromethane in, adding manganese dioxide (60.9 g, 0.7 µM), stirring at room temperature 12 h, filtering, drying by anhydrous magnesium sulphate, evaporate the solvent. Vacuum distillation, to obtain compound 5 (8.9 g, orange liquid, yield 90percent).
Reference: [1] Chemistry - A European Journal, 2010, vol. 16, # 42, p. 12718 - 12726
[2] Patent: CN108101874, 2018, A, . Location in patent: Paragraph 0006; 0017; 0020; 0023; 0026; 0028; 0031
[3] RSC Advances, 2014, vol. 4, # 25, p. 12834 - 12839
[4] Journal of the American Chemical Society, 1931, vol. 53, p. 1923
[5] Green Chemistry, 2017, vol. 19, # 5, p. 1315 - 1326
  • 2
  • [ 2493-04-1 ]
  • [ 20782-91-6 ]
YieldReaction ConditionsOperation in experiment
84% With 1,3,5-tribromo-hexahydro-<1,3,5>triazine-2,4,6-trione; triphenylphosphine In dichloromethane at 20℃; for 4 h; To a stirred solutionof triphenyl phosphine (39.40 g, 150.24 mmol, 4.3 eq) in dichloromethane (200 mL) was added tribromoisocyanuric acid (14.05 g, 38.34 mmol, 1.5 eq). After 30 min, the alcohol(4) (5 g, 34.94 mmol, 1 eq) was added and the suspension was stirred at room temperature for 4 h. After completion of the reaction, the precipitated cyanuric acid was filtered off and the organic layer was washed with water (4 × 100 mL) followedby brine solution. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The obtained residue was treated with n-hexane and filtered through a short column packed with silica gel (100-200 mesh). Evaporationof n-hexane gave the desired product 5. Yellow oily liquid; Yield: 6.33 g, 84 percent. IR (KBr, ν max , cm –1 ): 1526 and 1345 (NO2);1 H NMR (400 MHz, CDCl3) δ 4.49 (s, 2H), 6.64 (d, J = 4.0Hz, 1H, H 3 -furan), 7.28 (d, J = 4.0 Hz, 1H, H 4 -furan).
60% With phosphorus tribromide In dichloromethane at 0 - 20℃; for 1 h; To a stirred solution of A (928 mg, 6.50 mmol) in DCM (20m1), phosphorus tribromide (0.80 ml, 8.40 mmol) was added slowly at 0 °C and reaction mixture was stirred at room temperature for one hour. On completion, the reaction mixture was poured into crushed ice, neutralizedwith sodium bicarbonate solution and extracted with DCM,which on evaporation obtain the compoundB (800 mg) in 60percent isolated yield. 1H NMR (CDC13): 37.29 (d, 1H, JAB= 3.5 Hz, ArH), 6.65 (d, 1H, JAB= 3.5 Hz, ArH), 4.49 (s, 2H, CH2).
Reference: [1] Asian Journal of Chemistry, 2018, vol. 30, # 2, p. 312 - 316
[2] Patent: WO2017/17631, 2017, A2, . Location in patent: Paragraph 00310
[3] Medicinal Chemistry Research, 2013, vol. 22, # 12, p. 5940 - 5947
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