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[ CAS No. 25045-82-3 ]

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Chemical Structure| 25045-82-3
Chemical Structure| 25045-82-3
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Product Details of [ 25045-82-3 ]

CAS No. :25045-82-3 MDL No. :MFCD05863333
Formula : C7H5N3O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :163.13 g/mol Pubchem ID :595954
Synonyms :

Safety of [ 25045-82-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25045-82-3 ]

  • Upstream synthesis route of [ 25045-82-3 ]
  • Downstream synthetic route of [ 25045-82-3 ]

[ 25045-82-3 ] Synthesis Path-Upstream   1~3

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YieldReaction ConditionsOperation in experiment
100% With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; A solution of 600 mg (3.68 mmol) of 6-nitroimidazo[1,2-a]pyridine in 30 ml of ethanol was hydrogenated in the presence of 60 mg of palladium (10percent on activated carbon) at RT and standard pressure overnight. The reaction mixture was then filtered through Celite and the residue was washed with ethanol. The combined filtrates were concentrated under reduced pressure and dried. The crude product was used without further purification in the next stage. Yield: 512 mg (quant.). (0508) LC/MS [Method 5]: Rt=0.89 min; MS (ESIpos): m/z=134 (M+H)+, (0509) 1H-NMR (400 MHz, DMSO-d6): δ [ppm]=7.72-7.62 (m, 2H), 7.33 (d, 1H), 7.30 (d, 1H), 6.80 (dd, 1H), 4.83 (s, 2H)
74% With hydrogen In ethanol at 20℃; Inert atmosphere To a solution of 6-nitro-imidazo[l,2-a]pyridine (500 mg, 3 mmol) in EtOH (20 ml) was added Pd/C (30 mg, 0.3 mmol). The flask was evacuated and filled with N2 three times then evacuated and filled with H2 three times before stirring overnight at RT under H2. The mixture was filtered through celite under N2, concentrated under reduced pressure and run through a short silica column. The eluant was concentrated under vacuum to give the desired product as a dark green solid (295 mg, 74 percent). 1H NMR (400 MHz, DMSO-(Z6) δ ppm 4.87 (br. s, 2 H), 6.78 - 6.83 (m, 1 H), 7.27 - 7.36 (m, 2 H), 7.67 (dd, 1 H), 7.69 (s, 1 H); m/z (ES+APCI)+ : 134 [M+H]+.
Reference: [1] Patent: US2017/275282, 2017, A1, . Location in patent: Paragraph 0507-0509
[2] Patent: WO2009/122180, 2009, A1, . Location in patent: Page/Page column 105
[3] Yakugaku Zasshi, 1949, vol. 69, p. 496[4] Chem.Abstr., 1950, p. 4474
[5] Patent: US2016/272637, 2016, A1, . Location in patent: Paragraph 0511; 0512; 0513; 0514
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YieldReaction ConditionsOperation in experiment
77.6%
Stage #1: With hydrogenchloride In ethanol at 20℃; Reflux
Stage #2: at 20℃;
In a 250 mL single-necked flask, bromoacetaldehyde diethyl acetal (42.5 g, 215.7 mmol) was dissolved in 1 mol / L HCL(120 mL) and ethanol (20 mL), stirred at room temperature for 30 min, heated to reflux, stirred until the solution was clear, cooled to room temperature,Add NaHCO3 adjusted to near neutral,2-Amino-5-nitropyridine (15.0 g, 107.8 mmol) was added and reacted at room temperatureovernight. The reaction was completed, extracted with ethyl acetate (100mL × 3), the organic phase was collected and the solvent was evaporated to dryness under reduced pressure. The residue was passed through a silica gel column (PE:EA = 2: 1) to give 13.7 g of 6-nitroimidazo [1,2-a] pyridine yellow-brown crystals in a yield of 77.6percent.
Reference: [1] Patent: CN107129496, 2017, A, . Location in patent: Paragraph 0026-0028; 0014-0016; 0020-0022
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Reference: [1] Yakugaku Zasshi, 1949, vol. 69, p. 496[2] Chem.Abstr., 1950, p. 4474
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