Home Cart Sign in  
Chemical Structure| 25856-02-4 Chemical Structure| 25856-02-4

Structure of 25856-02-4

Chemical Structure| 25856-02-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 25856-02-4 ]

CAS No. :25856-02-4
Formula : C15H11BrO2
M.W : 303.16
SMILES Code : O=C(C1=CC=CC(Br)=C1)CC(C2=CC=CC=C2)=O

Safety of [ 25856-02-4 ]

Application In Synthesis of [ 25856-02-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25856-02-4 ]

[ 25856-02-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 618-89-3 ]
  • [ 98-86-2 ]
  • [ 25856-02-4 ]
YieldReaction ConditionsOperation in experiment
66% Sodium hydride (2.26 g, 60 %, 56.6 mmol) was suspended inTHF (35 mL) at 0C under an N2 atmosphere. A solution of <strong>[618-89-3]methyl 3-bromobenzoate</strong> 1 (7.43 g, 34.6 mmol) in THF (10 mL) was added with stirring. After 15 min, a solution of acetophenone 2 (4.12 g, 34.3 mmol) in THF (10 mL) was slowly added to the reaction mixture, and then the mixture was stirred at room temperature (rt) for 2 h. The reaction mixture was poured into cracked ice containing 1M hydrochloric acid (20 mL) with stirring. The organic layer was extracted with ethyl acetate (310 mL) and dried over sodium sulfate. After evaporation of the solvent under vacuum, the residue was purified by silica gel column chromatography (hexane/EtOAc 8 : 1 v/v) and recrystallization with ethanol afforded compound 3 (6.95 g,22.9 mmol, 66 %) as a yellow solid; mp 66-68C. nmax (KBr)/cm1 1599, 1517, 1456, 1225, 759. dH (400 MHz, CDCl3) 8.11(s, 1H, ArH), 8.00 (d, J 7.2, 2H, ArH), 7.91 (d, J 8.0, 1H, ArH),7.68 (d, J 8.0, 1H, ArH), 7.58 (t, J 7.2, 1H, ArH), 7.50 (t, J 7.8,2H, ArH), 7.37 (t, J 7.8, 1H, ArH), 6.81 (s, 1H, CH). dC(100 MHz, CDCl3) 186.25, 184.19, 137.73, 135.36, 132.89,130.39, 130.32, 128.91, 127.40, 125.84, 123.09, 93.43. m/z(high-resolution electrospray ionization mass spectrometry(HRMS-ESI)) 324.98361; calc. for C15H11BrO2Na [MNa]324.98346.
 

Historical Records