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Chemical Structure| 2591-98-2 Chemical Structure| 2591-98-2

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Chemical Structure| 2591-98-2

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Ye, Lihua ; Bae, Munhyung ; Cassilly, Chelsi D. ; Jabba, Sairam V. ; Thorpe, Daniel W. ; Martin, Alyce M. , et al.

Abstract: The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous system, but whether they also relay signals from intestinal microbes remains unknown. Using in vivo real-time measurements of EEC and nervous system activity in zebrafish, we discovered that the bacteria Edwardsiella tarda activate EECs through the receptor transient receptor potential ankyrin A1 (Trpa1) and increase intestinal motility. Microbial, pharmacol., or optogenetic activation of Trpa1+EECs directly stimulates vagal sensory ganglia and activates cholinergic enteric neurons by secreting the neurotransmitter 5-hydroxytryptamine (5-HT). A subset of indole derivatives of tryptophan catabolism produced by E. tarda and other gut microbes activates zebrafish EEC Trpa1 signaling. These catabolites also directly stimulate human and mouse Trpa1 and intestinal 5-HT secretion. These results establish a mol. pathway by which EECs regulate enteric and vagal neuronal pathways in response to microbial signals.

Keywords: Danio rerio ; bacterial tryptophan catabolism ; enteroendocrine cells ; gut microbes ; gut-brain axis communication ; indole ; indole-3-carboxaldehyde ; intestinal peristalsis ; serotonin

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Product Details of [ 2591-98-2 ]

CAS No. :2591-98-2
Formula : C10H9NO
M.W : 159.18
SMILES Code : O=CCC1=CNC2=C1C=CC=C2
MDL No. :MFCD00056920

Safety of [ 2591-98-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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