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[ CAS No. 259209-17-1 ]

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Chemical Structure| 259209-17-1
Chemical Structure| 259209-17-1
Structure of 259209-17-1 * Storage: {[proInfo.prStorage]}

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Product Details of [ 259209-17-1 ]

CAS No. :259209-17-1 MDL No. :MFCD08689552
Formula : C7H9BO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :167.96 g/mol Pubchem ID :-
Synonyms :

Safety of [ 259209-17-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 259209-17-1 ]

  • Downstream synthetic route of [ 259209-17-1 ]

[ 259209-17-1 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 259209-52-4 ]
  • [ 259209-17-1 ]
  • 6-(2-Hydroxy-3-methoxyphenyl)-6'-(2-hydroxy-4-methylphenyl)-2,2'-bipyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
33% II.50 50 50 Prepration of 6-(2-Hydroxy-3-methoxyphenyl)-6'-(2-hydroxy-4-methylphenyl)-2,2'-bipyridine 6-(2-Hydroxy-3-methoxyphenyl)-6'-(2-hydroxy-4-methylphenyl)-2,2'-bipyridine was prepared from 6-bromo-6'-(2-hydroxy-4-methylphenyl)-2,2'-bipyridine and 2-hydroxy-3-methoxyphenylboronic acid in 33% yield using method F; δH [2H6]-DMSO 13.52,(2H, b), 8.31,(2H, dd), 8.26,(1H, d), 8.21,(1H, d), 8.12,(1H, d), 8.02,(1H, d), 7.70,(1H, d), 7.09,(1H, d), 6.92, (1H, t), 6.82,(1H, d), 3.86,(3H, s), 2.32,(3H, s); MS 385 (MH)+; HPLC retention time (system 1) 4.21 minutes.
  • 2
  • [ 259209-17-1 ]
  • [ 1272672-24-8 ]
  • [ 1272672-25-9 ]
YieldReaction ConditionsOperation in experiment
28.3% With caesium carbonate In 1,4-dioxane; water at 160℃; for 0.666667h; microwave reactor; 24 To a solution of 1 -(4-bromophenyl)-2-chloro-7-hydroxy-5-oxo-4,5-dihydro-1 H- pyrrolo[3,2-b]pyridine-6-carbonitrile (Example 23) (150 mg, 0.41 1 mmol) in 1 ,4- dioxane (5 mL)/ water (3 ml.) were added [2-hydroxy-3-(methyloxy)phenyl]boronic acid (83 mg, 0.494 mmol), cesium carbonate (402 mg, 1.234 mmol) and Pd(PPh3)4 (1.0 mg, 1 .234 μηηοΙ). The reaction vessel was sealed and heated to 160 °C for 20 min in a microwave reactor. To complete the reaction, [2-hydroxy-3- (methyloxy)phenyl]boronic acid (83 mg, 0.494 mmol) and Pd(PPh3)4 (1.0 mg, 1.234 μηηοΙ) were added again and the reaction vessel was sealed and heated to 160 °C for 20 min in microwave reactor. After cooling, the reaction mixture was extracted, and the organic layer was washed with 1 N HCI solution and evaporated off. The residue was dissolved with a hot MeOH /CH3CN (80/20) mixture and treated with charcoal filtered. The filtrate was crystallined to give the product 2-chloro-7-hydroxy-1-[2'- hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1 H-pyrrolo[3,2-b]pyridine-6- carbonitrile (50 mg, 0.1 16 mmol, 28.3 % yield) as a white powder. 1H NMR: (DMSO- d6, 300MHz) δ 9.74 (br s, 1 H), 8.71 (s, 1 H), 7.56 (d, J = 8.4 Hz, 2H), 7.23 (d, J = 8.4 Hz, 2H), 7.02-6.84 (m, 3H), 5.94 (s, 1 H), 3.86 (s, 3H). LCMS: (M+H)+ : 408; Rt: 2.63 min. HRMS: calculated for C2iH15CIN304 (M+H)+ : 408.0751 ; found: 408.0765; Rt: 2.34 min.
  • 3
  • [ 259209-17-1 ]
  • [ 1346608-15-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / Reflux 2.1: dichloromethane / 3 h / 20 °C 2.2: 80 °C
  • 4
  • [ 259209-17-1 ]
  • [ 1346608-16-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / Reflux 2.1: dichloromethane / 3 h / 20 °C 2.2: 80 °C 3.1: ethanol; sodium / 80 °C
  • 5
  • [ 259209-17-1 ]
  • [ 1346606-83-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere 2: toluene / 80 °C 3: sodium / ethanol / 2 h / 90 °C
  • 6
  • [ 259209-17-1 ]
  • [ 1346607-24-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere 2.1: triethylamine; diphenyl phosphoryl azide / toluene / 5 h / 90 °C 2.2: 72 h / 50 °C 3.1: sodium hydroxide / ethanol / 90 °C
  • 7
  • [ 259209-17-1 ]
  • [ 1346606-89-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere 2: xylene / 0.25 h / 140 °C / microwave irradiation 3: ethanol; sodium / 1.5 h / Reflux
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