Home Cart 0 Sign in  

[ CAS No. 260352-79-2 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 260352-79-2
Chemical Structure| 260352-79-2
Structure of 260352-79-2 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 260352-79-2 ]

Related Doc. of [ 260352-79-2 ]

Alternatived Products of [ 260352-79-2 ]
Product Citations

Product Details of [ 260352-79-2 ]

CAS No. :260352-79-2 MDL No. :MFCD06797747
Formula : C8H12F2O2 Boiling Point : No data available
Linear Structure Formula :- InChI Key :JHIWVOJDXOSYLW-UHFFFAOYSA-N
M.W : 178.18 Pubchem ID :2761400
Synonyms :

Safety of [ 260352-79-2 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 260352-79-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 260352-79-2 ]

[ 260352-79-2 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 111-66-0 ]
  • [ 141-32-2 ]
  • [ 260352-79-2 ]
  • 2
  • [ 141-32-2 ]
  • ethyldimethylsilyl fluorosulfonyldifluoroacetate [ No CAS ]
  • [ 260352-79-2 ]
  • 3
  • [ 141-32-2 ]
  • chloromethyldimethylsilyl fluorosulfonyldifluoroacetate [ No CAS ]
  • [ 260352-79-2 ]
  • 4
  • [ 141-32-2 ]
  • 2-(trimethylsilyl)ethyl fluorosulfonyldifluoroacetate [ No CAS ]
  • [ 260352-79-2 ]
  • 5
  • [ 141-32-2 ]
  • [ 757203-27-3 ]
  • [ 260352-79-2 ]
  • 6
  • [ 141-32-2 ]
  • [ 120801-75-4 ]
  • [ 260352-79-2 ]
YieldReaction ConditionsOperation in experiment
59% A solution of butyl prop-2-enoate (80 g, 6.24 mol) and a catalytic amount of NaF (1 .57 g, 375 mmol) in anhydrous toluene (800 ml_) was degassed with nitrogen 3 times, and then refluxed for 1 hr. Then, tri methylsilyl difluoro(fluorosulfonyl)acetate (250 g, 9.99 mol) was added dropwise to the refluxing solution over a period of 40 mins. After the addition, the resulting pale colorless solution was refluxed under N2 for a further 8 hr. The reaction solution was cooled to room temperature to afford a pale yellow solution. The solvent was removed under vacuum at ~45 C, The combined residue (~130 ml_) was firstly distilled at 130 C under atmospheric pressure to remove residual toluene, and then distilled under reduced pressure (~0.02 atm) at the same temperature to give butyl 2,2-difluorocyclopropanecarboxylate (1-136) (65 g, 59%) as a colorless oil. 1H NMR (400 MHz, CDCI3) delta ppm 4.09 - 4.21 (m, 2 H), 2.36 - 2.47 (m, 1 H), 2.04 - 2.07 (m, 1 H), 1 .60 - 1 .66 (m, 3 H), 1 .36 - 1 .42 (m, 2 H), 0.94 (t, J = 7.2 Hz, 3 H).
  • 7
  • [ 260352-79-2 ]
  • [ 107873-03-0 ]
YieldReaction ConditionsOperation in experiment
75% With water; sodium hydroxide; for 14h;Reflux; A colorless solution of <strong>[260352-79-2]butyl 2,2-difluorocyclopropanecarboxylate</strong> (1-136) (65.0 g, 330 mmol) in aq .NaOH (750 ml_ H20, 52.5 g NaOH) was refluxed for ~14 hr. A pale yellow solution was formed. The reaction solution was cooled to room temperature, and then concentrated in vacuo to ~250 mL volume. In an ice bath (~0-5 C), the residue was adjusted to pH ~3-4 using cone, aq. HCI (~70 mL). The resulting solution was extracted with EtOAc (2 x 500 mL). The combined organic layers were dried over Na2S04 and concentrated under high vacuum to give 2,2-difluorocyclopropanecarboxylic acid (1-137) (30 g, 75%) as a yellow oil which gradually solidified on standing to give a pale yellow solid. 1H NMR (400 MHz, CDCI3) delta ppm 10.78 (s, 1 H), 2.41 - 2.47 (m, 1 H), 2.05 - 2.08 (m, 1 H), 1 .80 -1 .83 (m, 1 H).
  • 8
  • [ 75-05-8 ]
  • [ 260352-79-2 ]
  • [ 1186609-06-2 ]
YieldReaction ConditionsOperation in experiment
Referential Example 2 5-(2,2-Difluorocyclopropyl)-lH-pyrazol-3-amine (45) To a solution of MeCN (1.1 g, 16.8 mmol) in THF (60 mL) was added dropwise n-BuLi in THF (11.2 mL, 40.3 mmol) at -78C, and the reaction mixture was stirred at -78 C under N2 for 30 min. Butyl 2,2- difluorocyclopropanecarboxylate (3.0 g, 16.8 mmol) was added at -78 C, and the reaction mixture was allowed to warm to RT over 3 h. The reaction mixture was quenched with water and adjusted to pH 7 with IN HCl. The mixture was extracted with EtOAc, and the organic layer was washed with brine, dried (Na2S04), filtered and concentrated in vacuo to afford crude 3-(2,2-difluorocyclopropyl)-3- oxopropanenitrile. A mixture of crude 3-(2,2-difluorocyclopropyl)-3-oxopropanenitrile and hydrazine (2.0 g, 50.4 mmol, 85% pure) in EtOH (30 mL) was stirred at reflux for 16 h. The reaction mixture was concentrated to dryness under reduced pressure. The crude residue was purified by chromatography eluting with an EtO Ac/petroleum ether gradient (12.5 to 100% EtOAc) to afford 2.1 g (78.5%>) of 45 as a yellow solid: 1H NMR (400 MHz, DMSO-d6): delta 11.40 (br s, 1H), 5.26 (s, 1H), 4.80 (br s, 2H), 2.78 - 2.66 (m, 1H), 2.04 - 1.75 (m, 1H), 1.73 - 1.21 (m, 1H); MS (ESI+) m/z = 160.1 [M +1]+.
A solution of acetonitrile (0.97 mL, 18.5 mmol) in tetrahydrofuran(50 mL) was cooled to -78C and treated with n-butyllithium in hexanes (11.7 mL, 19.0 mmol) over 5 minutes. The reaction mixture was stirred for 30 minutes, and then n-butyl 2,2- difluorocyclopropane carboxylate (3.0 g, 16.8 mmol) was added. The reaction mixture was allowed to warm to room temperature over 2 hours. The reaction mixture was poured into water (25 mL) and acidified by addition of 10% aqueous hydrochloric acid. The organic layers were extracted into diethyl ether (3 X 30 mL), dried (MgSO4) and concentrated to afford crude 3-(2,2-difluorocyclopropyl)-3-oxo-propionitrile (2 g).
  • 9
  • [ 141-32-2 ]
  • [ 680-15-9 ]
  • [ 260352-79-2 ]
  • 10
  • [ 141-32-2 ]
  • [CoIII(meso-tetraphenylporphyrinato)(CF3)] [ No CAS ]
  • [ 260352-79-2 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 260352-79-2 ]

Fluorinated Building Blocks

Chemical Structure| 139229-57-5

[ 139229-57-5 ]

Ethyl 1-(trifluoromethyl)cyclopropanecarboxylate

Similarity: 0.86

Chemical Structure| 178312-47-5

[ 178312-47-5 ]

Ethyl 4,4-difluorocyclohexanecarboxylate

Similarity: 0.83

Chemical Structure| 681128-38-1

[ 681128-38-1 ]

Ethyl 3,3-difluorocyclobutanecarboxylate

Similarity: 0.83

Chemical Structure| 107873-03-0

[ 107873-03-0 ]

2,2-Difluorocyclopropanecarboxylic acid

Similarity: 0.82

Chemical Structure| 22515-16-8

[ 22515-16-8 ]

Diethyl 4,4-difluoroheptanedioate

Similarity: 0.80

Aliphatic Cyclic Hydrocarbons

Chemical Structure| 139229-57-5

[ 139229-57-5 ]

Ethyl 1-(trifluoromethyl)cyclopropanecarboxylate

Similarity: 0.86

Chemical Structure| 178312-47-5

[ 178312-47-5 ]

Ethyl 4,4-difluorocyclohexanecarboxylate

Similarity: 0.83

Chemical Structure| 681128-38-1

[ 681128-38-1 ]

Ethyl 3,3-difluorocyclobutanecarboxylate

Similarity: 0.83

Chemical Structure| 107873-03-0

[ 107873-03-0 ]

2,2-Difluorocyclopropanecarboxylic acid

Similarity: 0.82

Chemical Structure| 915213-54-6

[ 915213-54-6 ]

Ethyl 2-(4,4-difluorocyclohexyl)acetate

Similarity: 0.79

Esters

Chemical Structure| 139229-57-5

[ 139229-57-5 ]

Ethyl 1-(trifluoromethyl)cyclopropanecarboxylate

Similarity: 0.86

Chemical Structure| 178312-47-5

[ 178312-47-5 ]

Ethyl 4,4-difluorocyclohexanecarboxylate

Similarity: 0.83

Chemical Structure| 681128-38-1

[ 681128-38-1 ]

Ethyl 3,3-difluorocyclobutanecarboxylate

Similarity: 0.83

Chemical Structure| 22515-16-8

[ 22515-16-8 ]

Diethyl 4,4-difluoroheptanedioate

Similarity: 0.80

Chemical Structure| 915213-54-6

[ 915213-54-6 ]

Ethyl 2-(4,4-difluorocyclohexyl)acetate

Similarity: 0.79

; ;