Home Cart Sign in  
Chemical Structure| 2614-55-3 Chemical Structure| 2614-55-3

Structure of Ala-D-γ-Glu-Lys-D-Ala-D-Ala
CAS No.: 2614-55-3

Chemical Structure| 2614-55-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Roy Aerts ; Wouter Herrebout ; Christian Johannessen ;

Abstract: The glycopeptide vancomycin has an antimicrobial effect by halting the synthesis of the bacterial cell-wall by binding the D-Ala-D-Ala peptide motif of the cell-wall precursor Lipid II. This interaction has been extensively investigated using techniques such as XRD and NMR. Here, vancomycin complexed with Ala-γGlu-Lys-D-Ala-D-Ala (the pentapeptide part of Lipid II) is studied by means of Raman and Raman optical activity (ROA) spectroscopy. Where for conventional structural elucidation techniques, the direct study of a drug-biological target complex is routine, it is not the case for the ROA technique. Through experimental recordings and DFT-level spectral calculations of the complex, it was found that ROA specifically probes the conformation of vancomycin, even in the presence of the biological target. As such, it could be determined that no noticeable conformational changes are involved when binding Ala-γGlu-Lys-D-Ala-D-Ala. This work showcases the interest of directly examining interacting systems conformationally by means of ROA, potentially complementing and/or confirming findings from other studies, and eventually contributing to a more complete understanding of the structure–activity relationship of a drug compound.

Keywords: antibiotic ; intermolecular interactions ; Raman optical activity ; vancomycin

Purchased from AmBeed: ; 2614-55-3

Alternative Products

Product Details of [ 2614-55-3 ]

CAS No. :2614-55-3
Formula : C20H36N6O8
M.W : 488.54
SMILES Code : O=C(N[C@@H](C(O)=O)CCC(N[C@@H](CCCCN)C(N[C@H](C)C(N[C@H](C)C(O)=O)=O)=O)=O)[C@H](C)N
MDL No. :MFCD00133044

Safety of [ 2614-55-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
 

Historical Records