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Chemical Structure| 261763-34-2 Chemical Structure| 261763-34-2

Structure of 261763-34-2

Chemical Structure| 261763-34-2

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Product Details of [ 261763-34-2 ]

CAS No. :261763-34-2
Formula : C8H6F2O
M.W : 156.13
SMILES Code : O=CC1=C(F)C=CC(C)=C1F
MDL No. :MFCD01631333
Boiling Point : No data available
InChI Key :MXZXYEFIOADJMW-UHFFFAOYSA-N
Pubchem ID :2774137

Safety of [ 261763-34-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 261763-34-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 261763-34-2 ]

[ 261763-34-2 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 5292-43-3 ]
  • [ 261763-34-2 ]
  • [ 1422510-63-1 ]
YieldReaction ConditionsOperation in experiment
56% Intermediate 32A. tert-Butyl 3-(2,6-difluoro-3-methylphenyl)-3- hydroxypropanoate: To a suspension of zinc (1.256 g, 19.21 mmol) in dry tetrahydrofuran (18 mL) was added chlorotrimethylsilane (1.228 mL, 9.61 mmol). After 20 min, tert-butyl 2-bromoacetate (1.420 mL, 9.61 mmol) was added. The reaction was stirred at rt for 10 min, then heated at 40 C for 20 min. The reaction mixture was cooled to 0 C under Ar, and <strong>[261763-34-2]2,6-difluoro-3-methylbenzaldehyde</strong> (1.5 g, 9.61 mmol) in 3 mL of dry THF was added. The reaction was allowed to warm to rt and stirred overnight. The reaction mixture was quenched with 5% aqueous NaHC03, filtered, and rinsed with EtOAc. The filtrate was washed with water and brine, dried over MgS04, filtered, concentrated and purified by silica gel chromatography to yield the desired product (1.46 g, 56%). MS (ESI) m/z: 295.1 (M+Na)+
  • 2
  • [ 261763-34-2 ]
  • [ 1422510-64-2 ]
  • 3
  • [ 261763-34-2 ]
  • [ 1422510-62-0 ]
  • 4
  • [ 261763-34-2 ]
  • [ 106-47-8 ]
  • (E)-N-(4-chlorophenyl)-1-(2,6-difluoro-3-methylphenyl)methanimine [ No CAS ]
  • 5
  • [ 261763-34-2 ]
  • 1-(4-chlorophenyl)-5-(2,6-difluoro-3-methylphenyl)-1H-imidazole [ No CAS ]
  • 6
  • [ 261763-34-2 ]
  • [ 1193348-55-8 ]
  • 7
  • [ 261763-34-2 ]
  • 2-chloro-1-(4-chlorophenyl)-5-(2,6-difluoro-3-methylphenyl)-1H-imidazole [ No CAS ]
 

Historical Records

Technical Information

• Alkyl Halide Occurrence • Arndt-Eistert Homologation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Knoevenagel Condensation • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stetter Reaction • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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