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Chemical Structure| 267875-79-6 Chemical Structure| 267875-79-6

Structure of 267875-79-6

Chemical Structure| 267875-79-6

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Product Details of [ 267875-79-6 ]

CAS No. :267875-79-6
Formula : C22H27NO6
M.W : 401.45
SMILES Code : O=C(C(C=C(C)N1CC(OC(C)(C)C)=O)=C(OCC2=CC=CC=C2)C1=O)OCC

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Application In Synthesis of [ 267875-79-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 267875-79-6 ]

[ 267875-79-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 267875-78-5 ]
  • [ 49827-15-8 ]
  • [ 267875-79-6 ]
YieldReaction ConditionsOperation in experiment
77% With 40% potassium fluoride/alumina; In 1,2-dimethoxyethane; for 84h;Inert atmosphere; S-Benzyloxy-o-methyl-lflty-pyridinone-l-tert-butoxycarbonylmethyl^-carboxylic acid ethyl ester (6-3); [0267] To a 100 mL round-bottom flask was added 3.5 g (12.2 mmol) Bn-6-Me-3,2-HOPO (6-2). To this was added 5.3 g potassium fluoride on alumina (40 wt. percent, 36.5 mmol). These reageants were purged under nitrogen for 15 minutes, after which 45 mL dimethoxyentane was added. To this solution was added 8.83 g (36.5 mmol) tert-b\\xty\\ iodoacetate, and the reaction was left to stir for 2 days. After 2 days, an additional 15 mmol tert-b\\xty\\ iodoacetate was added. After an additional 1.5 days, the reaction mixture was filtered, the alumina was washed thoroughly with THF, the solvent was evaporated, and the resulting light-brown oil purified by a gradient flash silica column, (0-5percent MeOH in DCM). Yield 77percent.[0268] 1H NMR (300 MHz, DMSOd6, 25 0C): delta: 1.27(t, 3H), 1.48(s, 9H), 2.27(s, 3H), 4.27(q, 2H), 4.72(s, 2H), 5.23(s, 2H), 6.18(s, IH), 7.3(m, 3H), 7.48(m, 2H). ESI+-MS: 402.19 (401.18)[0269] 13C NMR (500 MHz, DMSOd6, 25 0C): delta: 13.7, 22.1, 29.0, 49.2, 60.0, 72.6, 72.9, 103.7, 127.3, 127.4, 128.7, 130,1, 133.0, 140.9, 145.2, 161.4, 165.0, 1167.3.
 

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