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[ CAS No. 2683-66-1 ]

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Chemical Structure| 2683-66-1
Chemical Structure| 2683-66-1
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Product Details of [ 2683-66-1 ]

CAS No. :2683-66-1 MDL No. :MFCD00047427
Formula : C12H11NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :201.22 g/mol Pubchem ID :-
Synonyms :

Safety of [ 2683-66-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2683-66-1 ]

  • Upstream synthesis route of [ 2683-66-1 ]
  • Downstream synthetic route of [ 2683-66-1 ]

[ 2683-66-1 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 2683-66-1 ]
  • [ 626-64-2 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1959, vol. 7, p. 149
[2] Journal of the Chemical Society, 1958, p. 1263,1264, 1266
  • 2
  • [ 2683-66-1 ]
  • [ 49826-70-2 ]
Reference: [1] Advanced Synthesis and Catalysis, 2017, vol. 359, # 10, p. 1752 - 1757
[2] Synlett, 2005, # 9, p. 1389 - 1392
[3] Journal of Organic Chemistry, 1959, vol. 24, p. 330,332
[4] Chemical and Pharmaceutical Bulletin, 1959, vol. 7, p. 149
  • 3
  • [ 2683-66-1 ]
  • [ 53937-02-3 ]
YieldReaction ConditionsOperation in experiment
49% for 1.5 h; Heating / reflux 4-Benzyloxypyridine 1-oxide (24.8 g,123 mmols) was refluxed in acetic anhydride (150 mL) for 1.5 hours. Cooling the system to room temperature, the system was concentrated under reduced pressure and the resulting residue was dissolved in a mixed solvent of ethyl acetate (150 mL) and methanol (10 mL), followed by stirring at 60°C for 2 hours. The solid formed upon cooling the system to room temperature was recovered by filtration to provide crude title compound (8.84 g). Concentrating the filtrate, additional crude title compound (4.17 g) was obtained. The combined crude product was recrystallized from a mixed solvent of methanol and ethyl acetate to provide the title compound (12.1 g, 49percent).
Reference: [1] Patent: EP1741703, 2007, A1, . Location in patent: Page/Page column 62-63
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 20, p. 5851 - 5856
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5310 - 5314
  • 4
  • [ 2683-66-1 ]
  • [ 85333-26-2 ]
Reference: [1] European Journal of Medicinal Chemistry, 2013, vol. 62, p. 649 - 660
Historical Records

Related Functional Groups of
[ 2683-66-1 ]

Aryls

Chemical Structure| 49826-70-2

[ 49826-70-2 ]

4-(Benzyloxy)pyridine

Similarity: 0.87

Related Parent Nucleus of
[ 2683-66-1 ]

Pyridines

Chemical Structure| 49826-70-2

[ 49826-70-2 ]

4-(Benzyloxy)pyridine

Similarity: 0.87