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Chemical Structure| 26988-59-0 Chemical Structure| 26988-59-0

Structure of 26988-59-0

Chemical Structure| 26988-59-0

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Product Details of [ 26988-59-0 ]

CAS No. :26988-59-0
Formula : C39H52N2O4S
M.W : 644.91
SMILES Code : O=C(O)[C@@H](NC(OC(C)(C)C)=O)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.C4(NC5CCCCC5)CCCCC4
MDL No. :MFCD26793566

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Application In Synthesis of [ 26988-59-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 26988-59-0 ]

[ 26988-59-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2799-07-7 ]
  • [ 58632-95-4 ]
  • [ 101-83-7 ]
  • [ 26988-59-0 ]
  • 2
  • [ 34619-03-9 ]
  • [ 2799-07-7 ]
  • [ 101-83-7 ]
  • [ 77-92-9 ]
  • [ 26988-59-0 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In 1,4-dioxane; A. N-boc-S-trityl-cysteine, dicyclohexylammonium salt (XX) To a solution of S-trityl cysteine (see Hiskey and Adams, J. Org. Chem., 30:1340, (1965)) (36.3 g, 0.10 mol) in dioxane (200 ml) and 1M aqueous NaOH (100 ml, 0.10 mol) was added di-t-butyl carbonate (25.36 g, 0.12 mol). The resulting opaque solution became warm and effervesced and the pH fell from 12 to 8 over one hour. After stirring for 90 min, 50percent aqueous citric acid (40 ml) was added and the resulting mixture (pH 4) was extracted with ether. The ether was washed with water, then saturated brine, dried (MgSO4), filtered and evaporated to give N-BOC-S-(triphenylmethyl)-cysteine as an oil. Half of this material was dissolved in ether (200 ml) and treated with dicyclohexylamine (10 ml, 50 mmol) to give compound (XX) as a white precipitate which was filtered off, washed with ether and dried (25.1 g, 78percent), mp 205°-207°.
 

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