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Chemical Structure| 27634-89-5 Chemical Structure| 27634-89-5

Structure of 27634-89-5

Chemical Structure| 27634-89-5

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Product Details of [ 27634-89-5 ]

CAS No. :27634-89-5
Formula : C13H16O
M.W : 188.27
SMILES Code : O=CC1=CC=C(C=C1)C1CCCCC1
MDL No. :MFCD11111735

Safety of [ 27634-89-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 27634-89-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27634-89-5 ]

[ 27634-89-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 27634-89-5 ]
  • [ 19008-43-6 ]
  • C27H27NO2 [ No CAS ]
  • 2
  • [ 27634-89-5 ]
  • [ 19008-43-6 ]
  • benzyl 4-((4-cyclohexylbenzyl)amino)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% General procedure d (Reductive amination using sodium triacetoxy borohodyride). To a solution of primary aniline (1 eq) and acetic acid (1 .1 eq) stirred in anhydrous dichloroethane (0.1 M) with 4 A mol. sieves was added 4-cyclohexylbenzaldehyde (1.5 eq). The solution was then stirred at rt for 5 mins after which Na(OAc)3BH (1 .5 eq) was added and the reactionallowed to stir at rt overnight. When TLC indicated the reaction was complete, the reaction was concentrated in vacuo and absorbed directly onto silica for column chromatography purification using a gradient of EtOAc and Hexane.Example 13 - Compou benzyl 4-((4-cyclohexylbenzyl)amino)benzoate Chemical Formula: C27H29NO2 Molecular Weight: 399.52 Compound 4c was synthesized according to general procedure d, yielding the final product 4c as a white solid (88%). < (400 MHz, -CDCI3) 1.28-1.48 (m, 5H, CH2), 1.71-1.93 (m, 5H, CH2), 2.42-2.55 (m, 1H, CH), 4.35 (s, 2H, CH2), 5.36 (s, 2H, CH2), 6.87 (d, J = 8.0 Hz, 2H, CH), 7.10-7.16 (m, 4H, CH), 7.33-7.47 (m, 5H, CH), 8.10 (d, J = 8.0 Hz, 2H, CH); 8C (100 MHz, t/-CDCl3) 26.2, 26.5, 34.1 , 44.1 , 46.8, 66.9, 126.9, 128.2, 128.2, 128.4, 128.5, 128.4, 131.3, 133.4, 135.1 , 147.8, 165.1 , 165.7; LRMS (ES+) Calcd for [C27H29NO2 + H] 399.22 found 399.16.
 

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