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Chemical Structure| 2764-59-2 Chemical Structure| 2764-59-2

Structure of 2764-59-2

Chemical Structure| 2764-59-2

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Product Details of [ 2764-59-2 ]

CAS No. :2764-59-2
Formula : C10H9Cl2N
M.W : 214.09
SMILES Code : ClCC1=CC=C2N=CC=CC2=C1.[H]Cl
MDL No. :MFCD20483711

Safety of [ 2764-59-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 2764-59-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2764-59-2 ]

[ 2764-59-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6281-32-9 ]
  • [ 2764-59-2 ]
YieldReaction ConditionsOperation in experiment
93% With thionyl chloride; In dichloromethane; at 20℃; for 1h;Inert atmosphere;Product distribution / selectivity; To a solution of <strong>[6281-32-9]quinolin-4-ylmethanol</strong> MDE 32046 (0.24 g, 1.51 mmol) in dry CH2Cl2 (10 mL) at 0 C. under N2 in a 50 mL round-bottomed flask equipped with a magnetic stirrer was added dropwise SOCl2 (2.3 mL, 31.2 mmol) and the mixture was stirred for 1 h at RT. The volatiles were then removed at 40 C. under vacuum and the residue was taken up in CH2Cl2 (20 mL) before concentration back to dryness at 40 C. under vacuum (done 3 times) to give 6-(chloromethyl)quinoline hydrochloride MDE 32048 as an off-white solid (301 mg, 93% yield). MW: 214.09; Yield: 93%; Off-white solid; Mp ( C.): 202.4 1H-NMR (CD3OD, delta): 3.55 (s, 2H, CH2), 6.48 (dd, 1H, J=7.0 Hz, ArH), 6.65-6.73 (m, 2H, 2*ArH), 6.95-6.97 (m, 2H, 2*ArH), 8.28 (s, 1H, ArH). 13C-NMR (CD3OD, delta): 41.7, 126.3, 128.3, 129.0, 131.9, 132.7, 138.7, 140.5, 142.0, 150.0. MS-ESI m/z (% rel. Int.): 178 ([MH]+, 35Cl, 100), 180 ([MH]+, 37Cl, 32).
 

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