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Chemical Structure| 280753-26-6 Chemical Structure| 280753-26-6

Structure of 280753-26-6

Chemical Structure| 280753-26-6

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Product Details of [ 280753-26-6 ]

CAS No. :280753-26-6
Formula : C10H6F4O2
M.W : 234.15
SMILES Code : O=C(O)/C=C/C1=C(C=C(F)C=C1)C(F)(F)F
MDL No. :MFCD00236297

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Application In Synthesis of [ 280753-26-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 280753-26-6 ]

[ 280753-26-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 141-82-2 ]
  • [ 90176-80-0 ]
  • [ 280753-26-6 ]
YieldReaction ConditionsOperation in experiment
49% With pyridine;piperidine; for 3h;Heating / reflux; A mixture of 4-FLUORO-2-TRIFLUOROMETHYL-BENZALDEHYDE (2 g, 10.2 mmol), malonic acid (1.2 g, 11.2 mmol), piperidine (0.087 g, 1 mmol) and pyridine (7 ml) was kept at reflux temperature until carbon dioxide formation ceased (3 h). After cooling to room temperature the reaction mixture was poured onto 40 g ice and 20 ml 6N HC1. The precipitate was isolated, washed with water and dried yielding 1.16 g (49 %) 3- (4-FLUORO-2-TRIFLUOROMETHYL-PHENYL)-ACRYLIC acid. MS: 233.0 (ESI-) lH-NMR (400MHZ, [D6] DMSO): 6.63 (d, lH), 7.59-7. 64 (m, LH), 7.70-7. 78 (m, 2H), 8.11-8. 14 (m, lH), 12.72 (br, 1H).
 

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