Alternatived Products of [ 28096-32-4 ]
Product Details of [ 28096-32-4 ]
| CAS No. : | 28096-32-4 |
MDL No. : | N/A |
| Formula : |
C19H17FIP
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
422.21
|
Pubchem ID : | - |
| Synonyms : |
|
Application In Synthesis of [ 28096-32-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 28096-32-4 ]
- 1
-
[ 2683-66-1 ]
-
[ 28096-32-4 ]
-
4-benzyloxy-2-(fluoromethyl)pyridine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 79% |
With lithium tert-butoxide In dimethyl sulfoxide at 40℃; for 2h; Inert atmosphere; regioselective reaction; |
4.4. General procedure for C-H fluoromethylation of heteroaryl N-oxides
General procedure: A mixture of heteroaryl N-oxide (0.4 mmol), [Ph3PCFH2]I (337.6 mg, 0.8 mmol), t-BuOLi (96.0 mg, 1.2 mmol) was added in a 10 mL Schlenk tube under N2 atmosphere, and then DMSO (4.0 mL) was added. The mixture was stirred at 40 °C for 2 h. After the reaction was complete, water was added. The resulting mixture was extracted with DCM for four times. The organic layer was washed with brine, dried over Na2SO4, filtered and removed under reduced pressure. The residue was purified by silica gel column chromatography to give the desired product (2a-2p). |
- 2
-
[ 14248-50-1 ]
-
[ 28096-32-4 ]
-
4-bromo-2-(fluoromethyl)pyridine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 49% |
With lithium tert-butoxide In dimethyl sulfoxide at 40℃; for 2h; Inert atmosphere; regioselective reaction; |
4.4. General procedure for C-H fluoromethylation of heteroaryl N-oxides
General procedure: A mixture of heteroaryl N-oxide (0.4 mmol), [Ph3PCFH2]I (337.6 mg, 0.8 mmol), t-BuOLi (96.0 mg, 1.2 mmol) was added in a 10 mL Schlenk tube under N2 atmosphere, and then DMSO (4.0 mL) was added. The mixture was stirred at 40 °C for 2 h. After the reaction was complete, water was added. The resulting mixture was extracted with DCM for four times. The organic layer was washed with brine, dried over Na2SO4, filtered and removed under reduced pressure. The residue was purified by silica gel column chromatography to give the desired product (2a-2p). |
- 3
-
[ 15177-57-8 ]
-
[ 28096-32-4 ]
-
3,5-dichloro-2-(fluoromethyl)pyridine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 58% |
With lithium tert-butoxide In dimethyl sulfoxide at 40℃; for 2h; Inert atmosphere; regioselective reaction; |
4.4. General procedure for C-H fluoromethylation of heteroaryl N-oxides
General procedure: A mixture of heteroaryl N-oxide (0.4 mmol), [Ph3PCFH2]I (337.6 mg, 0.8 mmol), t-BuOLi (96.0 mg, 1.2 mmol) was added in a 10 mL Schlenk tube under N2 atmosphere, and then DMSO (4.0 mL) was added. The mixture was stirred at 40 °C for 2 h. After the reaction was complete, water was added. The resulting mixture was extracted with DCM for four times. The organic layer was washed with brine, dried over Na2SO4, filtered and removed under reduced pressure. The residue was purified by silica gel column chromatography to give the desired product (2a-2p). |
- 4
-
[ 4053-38-7 ]
-
[ 28096-32-4 ]
-
2-(fluoromethyl)-8-methylquinoline
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 60% |
With lithium tert-butoxide In dimethyl sulfoxide at 40℃; for 2h; Inert atmosphere; regioselective reaction; |
4.4. General procedure for C-H fluoromethylation of heteroaryl N-oxides
General procedure: A mixture of heteroaryl N-oxide (0.4 mmol), [Ph3PCFH2]I (337.6 mg, 0.8 mmol), t-BuOLi (96.0 mg, 1.2 mmol) was added in a 10 mL Schlenk tube under N2 atmosphere, and then DMSO (4.0 mL) was added. The mixture was stirred at 40 °C for 2 h. After the reaction was complete, water was added. The resulting mixture was extracted with DCM for four times. The organic layer was washed with brine, dried over Na2SO4, filtered and removed under reduced pressure. The residue was purified by silica gel column chromatography to give the desired product (2a-2p). |
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