Structure of 28443-52-9
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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| CAS No. : | 28443-52-9 |
| Formula : | C8H8ClNO2 |
| M.W : | 185.61 |
| SMILES Code : | CC(NC1=CC=C(Cl)C(O)=C1)=O |
| English Name : | N-(4-Chloro-3-hydroxyphenyl)acetamide |
| MDL No. : | MFCD09878312 |
| InChI Key : | FWPNOLFNLHAULD-UHFFFAOYSA-N |
| Pubchem ID : | 14122483 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| (i) K2CO3, Py, (ii) /BRN= 1887275/; Multistep reaction; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| (i) aq. NaOH, (ii) aq. (NH4)2S2O8; Multistep reaction; | ||
| With sodium hydroxide In ethanol |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With ammonium peroxydisulfate In water; acetone at 0℃; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| (i) K2CO3, Py, (ii) /BRN= 3497597/; Multistep reaction; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With ammonium peroxydisulfate |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With ammonium peroxydisulfate In water; acetone |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 3-Hydroxy-4-chlor-anilin, Acetylchlorid; | ||
| 5-Amino-2-chlorphenol, Essigsaeureanhydrid; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| Multi-step reaction with 2 steps 1: (NH4)2S2O8 / acetone; H2O 2: Na2S2O4, aq. NaOH / ethanol |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With acetic anhydride In 1,4-dioxane | Preparation of 2-chloro-5-acetaminophenol Preparation of 2-chloro-5-acetaminophenol 0.05 Mole (7.17 grams) of 2-chloro-5-aminophenol is dissolved in 21 cc of dioxane at 75°C. There is then added, with agitation, 0.05 mole (5.1 grams) of acetic anhydride. At the end of this addition, the reaction medium is maintained for 10 minutes at 70°C and then cooled. The raw product which has crystallized in then filtered and recrystallized in a hydroalcoholic medium. It exhibits a melting point of 212°C. 2-fluoro-5-acetamino phenol is prepared in a similar manner. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With caesium carbonate In N,N-dimethyl-formamide for 18h; Reflux; |

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