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Chemical Structure| 28443-52-9 Chemical Structure| 28443-52-9

Structure of 28443-52-9

Chemical Structure| 28443-52-9

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Product Details of [ 28443-52-9 ]

CAS No. :28443-52-9
Formula : C8H8ClNO2
M.W : 185.61
SMILES Code : CC(NC1=CC=C(Cl)C(O)=C1)=O
English Name :N-(4-Chloro-3-hydroxyphenyl)acetamide
MDL No. :MFCD09878312
InChI Key :FWPNOLFNLHAULD-UHFFFAOYSA-N
Pubchem ID :14122483

Safety of [ 28443-52-9 ]

Application In Synthesis of [ 28443-52-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 28443-52-9 ]

[ 28443-52-9 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 116-82-5 ]
  • [ 28443-52-9 ]
  • [ 38912-95-7 ]
YieldReaction ConditionsOperation in experiment
(i) K2CO3, Py, (ii) /BRN= 1887275/; Multistep reaction;
  • 2
  • [ 28443-52-9 ]
  • [ 7575-35-1 ]
  • [ 55302-69-7 ]
YieldReaction ConditionsOperation in experiment
(i) aq. NaOH, (ii) aq. (NH4)2S2O8; Multistep reaction;
With sodium hydroxide In ethanol
  • 3
  • [ 28443-52-9 ]
  • [ 2628-69-5 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With ammonium peroxydisulfate In water; acetone at 0℃;
  • 4
  • [ 28443-52-9 ]
  • [ 26868-32-6 ]
  • [ 38920-03-5 ]
YieldReaction ConditionsOperation in experiment
(i) K2CO3, Py, (ii) /BRN= 3497597/; Multistep reaction;
  • 5
  • [ 28443-52-9 ]
  • [ 57838-74-1 ]
  • [ 56330-29-1 ]
YieldReaction ConditionsOperation in experiment
With ammonium peroxydisulfate
  • 6
  • [ 28443-52-9 ]
  • [ 81263-51-6 ]
  • [ 57838-70-7 ]
YieldReaction ConditionsOperation in experiment
With ammonium peroxydisulfate In water; acetone
YieldReaction ConditionsOperation in experiment
3-Hydroxy-4-chlor-anilin, Acetylchlorid;
5-Amino-2-chlorphenol, Essigsaeureanhydrid;
  • 8
  • [ 28443-52-9 ]
  • [ 57839-22-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: (NH4)2S2O8 / acetone; H2O 2: Na2S2O4, aq. NaOH / ethanol
  • 9
  • [ 6358-06-1 ]
  • [ 28443-52-9 ]
  • [ 1187477-80-0 ]
YieldReaction ConditionsOperation in experiment
With acetic anhydride In 1,4-dioxane Preparation of 2-chloro-5-acetaminophenol Preparation of 2-chloro-5-acetaminophenol 0.05 Mole (7.17 grams) of 2-chloro-5-aminophenol is dissolved in 21 cc of dioxane at 75°C. There is then added, with agitation, 0.05 mole (5.1 grams) of acetic anhydride. At the end of this addition, the reaction medium is maintained for 10 minutes at 70°C and then cooled. The raw product which has crystallized in then filtered and recrystallized in a hydroalcoholic medium. It exhibits a melting point of 212°C. 2-fluoro-5-acetamino phenol is prepared in a similar manner.
  • 10
  • [ 75-30-9 ]
  • [ 28443-52-9 ]
  • [ 1887015-39-5 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate In N,N-dimethyl-formamide for 18h; Reflux;
 

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