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[ CAS No. 286836-04-2 ]

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Chemical Structure| 286836-04-2
Chemical Structure| 286836-04-2
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Product Details of [ 286836-04-2 ]

CAS No. :286836-04-2 MDL No. :MFCD09056787
Formula : C8H4BrFO Boiling Point : 233.4±20.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :215.02 g/mol Pubchem ID :22144820
Synonyms :

Safety of [ 286836-04-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 286836-04-2 ]

  • Upstream synthesis route of [ 286836-04-2 ]
  • Downstream synthetic route of [ 286836-04-2 ]

[ 286836-04-2 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 1249506-21-5 ]
  • [ 286836-04-2 ]
YieldReaction ConditionsOperation in experiment
100% at 230℃; for 1 h; Inert atmosphere; Sealed tube; Microwave irradiation c) 5 -bromo-7-fluoro- 1 -benzofuranA solution of 5-bromo-7-fluoro-l-benzofuran-2-carboxylic acid (1.274 mmol) in quinoline (2 mL) was treated with copper dust (0.236 mmol). The reaction was purged with nitrogen, sealed and irradiated in a microwave reactor at 230 °C for 60 min. The solution was diluted with ethyl acetate and was filtered through Celite. The filtrate was concentrated in vacuo, and the residue was purified by flash chromatography (hexanes) to provide the title compound as a clear oil (280 mg, 100percent yield). 1H NMR (400 MHz,DMSO-de) δ ppm 8.17 (d, J=2.02 Hz, 1 H) 7.77 (d, J=1.77 Hz, 1 H) 7.55 (dd, J=10.48, 1.64 Hz, 1 H) 7.07 (dd, J=3.16, 2.15 Hz, 1 H).
Reference: [1] Patent: WO2011/103546, 2011, A1, . Location in patent: Page/Page column 122
  • 2
  • [ 2105-94-4 ]
  • [ 253429-19-5 ]
  • [ 286836-04-2 ]
Reference: [1] Patent: EP1204654, 2003, B1,
  • 3
  • [ 251300-28-4 ]
  • [ 286836-04-2 ]
Reference: [1] Patent: WO2011/103546, 2011, A1,
  • 4
  • [ 1332333-59-1 ]
  • [ 286836-04-2 ]
Reference: [1] Patent: WO2011/103546, 2011, A1,
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