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Chemical Structure| 10203-08-4 Chemical Structure| 10203-08-4
Chemical Structure| 10203-08-4

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Product Details of 3,5-Dichlorobenzaldehyde

CAS No. :10203-08-4
Formula : C7H4Cl2O
M.W : 175.01
SMILES Code : O=CC1=CC(Cl)=CC(Cl)=C1
MDL No. :MFCD00003352
InChI Key :CASRSOJWLARCRX-UHFFFAOYSA-N
Pubchem ID :35746

Safety of 3,5-Dichlorobenzaldehyde

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:1759
Packing Group:

Application In Synthesis of 3,5-Dichlorobenzaldehyde

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10203-08-4 ]

[ 10203-08-4 ] Synthesis Path-Downstream   1~8

  • 3
  • [ 10203-08-4 ]
  • [ 22259-53-6 ]
  • [1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-(1H-indol-3-ylmethyl)-amine [ No CAS ]
  • 4
  • [ 10203-08-4 ]
  • [ 76-05-1 ]
  • [ 162167-97-7 ]
  • [1-(3,5-dichlorobenzyl)piperidin-3-yl]methanamine bis(trifluoroacetate) salt [ No CAS ]
  • 5
  • [ 10203-08-4 ]
  • [ 14401-72-0 ]
  • 6
  • [ 10203-08-4 ]
  • [ 3290-06-0 ]
  • 7
  • [ 10203-08-4 ]
  • [ 120-35-4 ]
  • 3-(3,5-Dichloro-benzylamino)-4-methoxy-N-phenyl-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; acetic acid; Example 51 3-(3,5-Dichloro-benzylamino)-4-methoxy-N-phenyl-benzamide Prepared according to the procedure of Example 50 using 3,5-dichloro-benzaldehyde (0.88 g, 5.0 mmol), 3-amino-4-methoxy-N-phenyl-benzamide (1.22 g, 5.0 mmol), acetic acid (0.24 g, 5.3 mmol), and sodium triacetoxyborohydride (1.12 mmol) to afford the product (0.65 g); m.p. 164-165 C. after recrystallization from ethanol. Calculated for C21H18Cl2N2O2: C, 62.86; H, 4.52; N, 6.98. Found: C, 62.58; H, 4.41; N, 6.83.
  • 8
  • [ 10203-08-4 ]
  • [ 1986-47-6 ]
  • (1S*,2R*)-N-(3,5-dichlorobenzyl)-2-phenylcyclopropan-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
12% General procedure: Trans-2-phenylcyclopropylamine hydrochloride (1.0 eq.), acetic acid (1.0eq.) and the appropriate aldehyde (0.9 eq.) were dissolved in around bottom flask in 10 mL dry DCE. The reaction mixture was stirred gently at room temperature for 2 h before sodium triacetoxyborohydride (3.0 eq.) was added in small portions to the reaction vessel. The reaction was monitored by TLC and quenched using 10 mL of an aqueous (5%) NaHCO3 solution. The organic layer was separated and the aqueous layer extracted three times with10 mL of DCE. All organic layers were combined, dried over anhydrous Na2SO4, concentrated in vacuo and purified using flash chromatography (silica gel; cyclohexane/ethyl acetate) to give the desired compound.
 

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Technical Information

• Alkyl Halide Occurrence • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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