Tranylcypromine (SKF 385) hydrochloride | LSD1/MAO Inhibitor

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Tranylcypromine is a dual inhibitor of both MAO-A/B and LSD1.

Synonyms: SKF 385 hydrochloride; Tranylcypromine (hydrochloride); trans-2-Phenylcyclopropylamine

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Quality Control of Tranylcypromine HCl Purity: 97% SDS Specification

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Product Details of Tranylcypromine HCl

CAS No. :	1986-47-6
Formula :	C₉H₁₂ClN
M.W :	169.65
SMILES Code :	N[C@H]1[C@H](C2=CC=CC=C2)C1.[H]Cl
Synonyms :	SKF 385 hydrochloride; Tranylcypromine (hydrochloride); trans-2-Phenylcyclopropylamine
MDL No. :	MFCD00063602

Safety of Tranylcypromine HCl

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P501-P270-P264-P301+P310+P330-P405
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Application In Synthesis of Tranylcypromine HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1986-47-6 ]

[ 1986-47-6 ] Synthesis Path-Downstream 1~35

1
[ 22118-09-8 ]
[ 1986-47-6 ]
[ 133941-07-8 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

2
[ 20260-53-1 ]
[ 1986-47-6 ]
[ 133941-05-6 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

3
[ 109822-09-5 ]
[ 1986-47-6 ]
[ 133941-11-4 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

4
[ 1986-47-6 ]
[ 21087-29-6 ]
[ 4407-36-7 ]

References: [1]Journal of Organic Chemistry,1984,vol. 49,p. 4560 - 4562.

5
[ 1986-47-6 ]
[ 22128-62-7 ]
[ 133941-13-6 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

6
[ 1986-47-6 ]
[ 4801-27-8 ]
[ 133941-14-7 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

7
[ 1986-47-6 ]
[ 107-08-4 ]
((1R,2S)-2-Phenyl-cyclopropyl)-dipropyl-amine [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1485 - 1493.

8
((1SR,2RS)-tert-butyl-2-phenylcyclopropyl)carbamate [ No CAS ]
[ 1986-47-6 ]

References: [1]Journal of the American Chemical Society,2010,vol. 132,p. 6827 - 6833.
[2]Journal of Medicinal Chemistry,1996,vol. 39,p. 1485 - 1493.

9
[ 185256-47-7 ]
[ 1986-47-6 ]

References: [1]Synthetic Communications,1999,vol. 29,p. 567 - 572.
[2]Journal of the American Chemical Society,2010,vol. 132,p. 6827 - 6833.

10
[ 1986-47-6 ]
[ 64-19-7 ]
[ 21087-29-6 ]
[ 21040-45-9 ]
[ 7217-71-2 ]

References: [1]Journal of Organic Chemistry,1999,vol. 64,p. 7756 - 7762.
[2]Journal of Organic Chemistry,1999,vol. 64,p. 7756 - 7762.

11
[ 64-18-6 ]
[ 1986-47-6 ]
N-((1R*,2S*)-2-phenylcyclopropyl)formamide [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2000,vol. 35,p. 599 - 618.

12
[ 119-61-9 ]
[ 1986-47-6 ]
trans-benzhydrylene-(2-phenylcyclopropyl)-amine [ No CAS ]

References: [1]Organic Letters,2001,vol. 3,p. 4087 - 4089.

13
[ 1986-47-6 ]
[ 100-52-7 ]
trans-2-phenyl-N-[(1E)-phenylmethylene]cyclopropanamine [ No CAS ]

References: [1]Organic Letters,2001,vol. 3,p. 4087 - 4089.

14
[ 1986-47-6 ]
[ 98-86-2 ]
trans-E-(2-phenylcyclopropyl)-(1-phenylethylidene)-amine [ No CAS ]

References: [1]Organic Letters,2001,vol. 3,p. 4087 - 4089.

15
[ 1986-47-6 ]
[ 333333-74-7 ]
[ 750644-54-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 2995 - 3007.

16
[ 1986-47-6 ]
2-methyl-2,3-diphenyl-3,4-dihydro-2H-pyrrole [ No CAS ]

References: [1]Organic Letters,2001,vol. 3,p. 4087 - 4089.

17
[ 1986-47-6 ]
[ 60106-90-3 ]

References: [1]European Journal of Medicinal Chemistry,2000,vol. 35,p. 599 - 618.

18
[ 1986-47-6 ]
N-methyl-2-methylamino-3-naphthalen-2-yl-N-(2-phenyl-cyclopropyl)-propionamide [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2000,vol. 35,p. 599 - 618.

19
[ 1986-47-6 ]
methyl-{1-[methyl-(2-phenyl-cyclopropyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid tert-butyl ester [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2000,vol. 35,p. 599 - 618.

20
[ 1986-47-6 ]
(E)-5-Amino-5-methyl-hex-2-enoic acid methyl-{(R)-1-[methyl-(2-phenyl-cyclopropyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-amide [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2000,vol. 35,p. 599 - 618.

21
[ 1986-47-6 ]
[(E)-1,1-Dimethyl-4-(methyl-{(R)-1-[methyl-(2-phenyl-cyclopropyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-but-3-enyl]-carbamic acid tert-butyl ester [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2000,vol. 35,p. 599 - 618.

22
[ 939-90-2 ]
[ 1986-47-6 ]

References: [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1485 - 1493.
[2]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 2388 - 2399.
[3]Angewandte Chemie - International Edition,2018,vol. 57,p. 9501 - 9504.
Angew. Chem.,2018,vol. 130,p. 9645 - 9648,4.

23
[ 5861-31-4 ]
[ 1986-47-6 ]

References: [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1485 - 1493.

24
[ 103-26-4 ]
paraformaldehyde [ No CAS ]
[ 1986-47-6 ]

References: [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1485 - 1493.

25
[ 1986-47-6 ]
(+/-)-trans-2-oxo-2-<(2-phenylcyclopropyl)amino>ethyl-3-pyridinecarboxylate [ No CAS ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

26
[ 1986-47-6 ]
[ 133941-15-8 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

27
[ 1986-47-6 ]
[ 133941-12-5 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

28
[ 1986-47-6 ]
[ 133941-16-9 ]

References: [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261.

29
[ 2510-37-4 ]
[ 1986-47-6 ]
C₁₅H₁₆N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20℃; for 24.5h;	304 mg (0.928 mmol, 1.05 equivalents) of TOTU and 323 mul (1.857 mmol, 2.1 equivalents) of ethyldiisopropylamine were added to 0.973 mmol (1.0 equivalent) of the respective carboxylic acid in 2 ml of absolute dimethylformamide at 0C and the mixture was stirred for 20 minutes at 0C. Subsequently, 0.884 mmol (1.0 equivalent) of the respective arylcycloalkylamine hydrochloride, dissolved in 2 ml of absolute dimethylformamide, were added and the mixture was stirred for 30 minutes at 0C and for 24 h at room temperature. The reaction mixture was filtered, the filter cake washed with 20 ml of ethyl acetate and the resulting solution washed with 20 ml of 5% aqueous sodium hydrogencarbonate solution and 20 ml of 5% aqueous sodium chloride solution. The organic phase was dried over Chromabond XTR and evaporated. The obtained raw product was purified by preparative HPLC (RP-18, acetonitrile/water + 0.1 % trifluoroacetic acid).

References: [1]Patent: EP1388535,2004,A1 .Location in patent: Page 14-15.

30
[ 1986-47-6 ]
[ 100-52-7 ]
(1S*,2R*)-N-benzyl-2-phenylcyclopropan-1-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%		General procedure: Trans-2-phenylcyclopropylamine hydrochloride (1.0 eq.), acetic acid (1.0eq.) and the appropriate aldehyde (0.9 eq.) were dissolved in around bottom flask in 10 mL dry DCE. The reaction mixture was stirred gently at room temperature for 2 h before sodium triacetoxyborohydride (3.0 eq.) was added in small portions to the reaction vessel. The reaction was monitored by TLC and quenched using 10 mL of an aqueous (5%) NaHCO3 solution. The organic layer was separated and the aqueous layer extracted three times with10 mL of DCE. All organic layers were combined, dried over anhydrous Na2SO4, concentrated in vacuo and purified using flash chromatography (silica gel; cyclohexane/ethyl acetate) to give the desired compound.
		Example 7: frans-(+/-)-Benzyl-(2-phenyl-cyclopropyl)-amine 11; [000204] To a stirred solution of trans-(+/-)-2-Phenylcyclopropylamine hydrochloride (50 mg, 0.295 mmol) in MeOH (1 ml_) were added benzaldehyde (27 uL, 0.266 mmol) and sodium cyanoborohydride (22 mg, 0.354 mmol). The mixture was stirred at 0 C for 1 h followed at room temperature overnight. To the reaction mixture was added crushed ice, and the acetonitril was removed under vacuum. The aqueous residue was extracted with CH2CI2. The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative TLC using a mixture of EtOAc/Et3N (95:5) as a developing solvent to afford the title compound as a colorless oil (15.4 mg). 1H NMR (CDCI3): delta (ppm) 7.40-7.25 (m, 9 H), 7.18 (m, 1 H), 7.03 (d, 2 H, J = 7.3 Hz), 3.92 (s, 2 H), 2.42 (m, 1 H), 2.25 (m, br. s, 1 H), 1.97 (m, 1 H), 1.14 (m, 1 H), 1.01 (m, 1 H). 13C NMR (CDCI3): delta (ppm) 142.7, 140.7, 128.8 (2), 128.7 (2), 128.6 (2), 127.4, 126.3 (2), 125.9, 54.0, 41.6, 25.8, 17.5. HRMS (ESI) calculated for Ci6Hi8N+ [MH+] 224.1439; found, 224.1440.

References: [1]European Journal of Medicinal Chemistry,2018,vol. 144,p. 52 - 67.
[2]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 35; 78.

31
[ 1986-47-6 ]
[ 2258-42-6 ]
N-((1R*,2S*)-2-phenylcyclopropyl)formamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine; In tetrahydrofuran; at -15 - 20℃; for 1.5h;	Example 3: Preparation of trans-(+/-)-Methyl-(2-phenyl-cyclopropyl)-amine; 7[000199] Acetic formic anhydride was generated by dropwise addition of formic acid (0.36 mL, 9.6 mmol) to acetic anhydride ( 0.73 ml_, 7.8 mmol) maintained on ice followed at 50 C for 2 h. The mixture was cooled to room temperature, and THF (5 mL) was added. This mixture (0.6 mL) containing acetic formic anhydride (0.3 mmol) was added to a solution of trans-(+/-)-2-phenyl-cyclopropylamine hydrochloride (50 mg, 0.3 mmol) in THF (1 mL) at -15 C followed by addition of Lambda/-methylmorpholine (45 uL, 0.3 mmol). The resulting mixture was stirred at -15 C for 30 min and at room temperature for 1 h, filtered out insoluble materials, and concentrated in vacuo. The crude residue (65 mg) was dissolved in THF (1.2 mL), and to the solution was added 1.0 M solution of borane dimethylsulfide complex in THF (0.75 mL). After the mixture was stirred at 65 C overnight, the reaction was quenched by 10% aqueous HCI. The mixture was concentrated under reduced pressure to remove THF, and the residual aqueous solution was washed with Et2theta (x1), neutralized with 10% aqueous NaOH, and then extracted with Et2O (x3). The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative TLC using a mixture of EtOAc/Et3N/MeOH (8:1:1) as a developing solvent to afford the title compound as a colorless oil (21 mg). 1H NMR (CDCI3): delta (ppm) 7.30-7.25 (m, 2 H), 7.20-7.16 (m, 1 H), 7.09-7.06 (m, 2 H), 2.54 (br. s, 3 H), 2.34 (m, 1 H), 1.92 (m, 1 H), 1.76 (br. s, 1 H), 1.12-1.06 (m, 1 H), 1.02-0.98 (m, 1 H). 13C NMR (CDCI3): delta (ppm) 142.8, 128.6 (2), 126.3 (2), 125.9, 43.7, 36.2, 25.3, 17.5. HRMS (ESI) calculated for C10Hi4N+ [MH+] 148.1126; found, 148.1124.

References: [1]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 35; 75.

32
[ 1986-47-6 ]
[ 2258-42-6 ]
C₁₁H₁₃NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine; In tetrahydrofuran; at -15 - 20℃; for 1.5h;	Example 4: fra/7s-(+/-)-Methyl-(2-phenyl-cyclopropylmethyl)-amine; 8[000200] Acetic formic anhydride was generated by dropwise addition of formic acid (0.18 mL, 4.8 mmol) to acetic anhydride ( 0.365 ml_, 3.9 mmol) maintained on ice followed at 50 C for 2 h. The mixture was cooled to room temperature, and THF (4.5 mL) was added. This mixture (0.53 mL) containing acetic formic anhydride (0.408 mmol) was added to a solution of trans-(+/-)-2-phenyl-cyclopropylmethylamine hydrochloride (30 mg, 0.163 mmol) in THF (1 mL) at -15 C followed by addition of Lambda/-methylmorpholine (17.9 uL, 0.163 mmol). The resulting mixture was stirred at -15 "C for 30 min and at room temperature for 1 h, filtered out insoluble materials, and concentrated in vacuo.[000201] The crude residue (42 mg) was dissolved in THF (1.2 mL), and to the solution was added 1.0 M solution of borane dimethylsulfide complex in THF (0.41 mL). After the mixture was stirred at 65 C overnight, the reaction was quenched by 10% aqueous HCI. The mixture was concentrated under reduced pressure to remove THF, and the residual aqueous solution was washed with Et2O (x1), neutralized with 10% aqueous NaOH, and then extracted with Et2O (x3). The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative TLC using a mixture of EtOAc/Et.3N/MeOH (8:1:1) as a developing solvent to afford the title compound as a colorless oil (14.0 mg). 1H NMR (CDCI3):delta (ppm) 7.29-7.24 (m, 2 H), 7.18-7.15 (m, 1 H), 7.10-7.07 (m, 2 H), 2.66 (br. d, 2 H), 2.49 (br. s, 3 H), 2.37 (br. s, 1 H), 1.77 (m, 1 H), 1.38-1.32 (m, 1 H), 0.99-0.85 (m, 2 H). 13C NMR (CDCI3): delta (ppm) 143.3, 128.7, 126.2, 125.9, 56.5, 36.5, 23.3, 22.5, 15.1. HRMS (ESI) calculated for CnH16N+ [MH+] 162.1283; found, 162.1285.

References: [1]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 35; 76.

33
[ 50-00-0 ]
[ 1986-47-6 ]
[ 14177-80-1 ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine; sodium cyanoborohydride; acetic acid; In water; acetonitrile; at 20℃; for 0.666667h;	Example 5: frans-(+/-)-Dimethyl-(2-phenyl-cyclopropyl)-amine; 9[000202] To a stirred solution of fra/7s-(+/-)-2-Phenylcyclopropylamine hydrochloride (34 mg, 0.2 mmol) in acetonitrile/H2theta (1 :1 , v/v) (5 ml_) were added N- methylmorpholine (45 uL, 0.4 mmol), 37% aqueous formaldehyde (0.16 mL, 2.0 mmol), and sodium cyanoborohydride (40 mg, 0.6 mmol). Glacial acetic acid (40 uL) was added to the mixture over 10 min and the reaction was stirred at room temperature for 30 min. To the reaction mixture was added crushed ice, and the acetonitrile was removed under vacuum. The aqueous residue was extracted with CH2CI2. The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative TLC using a mixture of EtOAc/Et3N (95:5) as a developing solvent to afford the title compound as a colorless oil (19.7 mg). 1H NMR (CDCI3): delta (ppm) 7.34-7.26 (m, 2 H), 7.18 (t, 1 H, J = 7.3 Hz), 7.09 (d, 2 H, J = 7.2 Hz), 2.74 (d, 2 H, J = 3.6 Hz), 2.42 (s, 6 H), 2.00 (m, 1 H), 1.83 (m, 1 H), 1.13 (m, 1 H), 0.99 (m, 1 H). 13C NMR (CDCI3): delta (ppm) 142.5, 128.6 (2), 126.5 (2), 126.0, 50.6, 45.4 (2), 25.7, 17.6. HRMS (ESI) calculated for CnH16N+ [MH+] 162.1283; found, 162.1279.

References: [1]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 35; 77.

34
[ 1986-47-6 ]
[ 67-64-1 ]
trans-N-isopropyl-(2-phenylcyclopropyl)amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 6: Preparation of trans-(+/-)-lsopropyl-(2-phenyl-cyclopropyl)-amine 10; [000203] To a stirred solution of trans-(+/-)-2-Phenylcyclopropylamine hydrochloride (50 mg, 0.295 mmol) in MeOH (1 mL) were added acetone (21.7 uL, 0.295 mmol) and sodium cyanoborohydride (22 mg, 0.354 mmol). The mixture was stirred at 0 C for 1 h followed at room temperature overnight. To the reaction mixture was added EPO <DP n="79"/>crushed ice, and the acetonitril was removed under vacuum. The aqueous residue was extracted with CH2CI2. The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative TLC using a mixture of EtOAc/Et3N (95:5) as a developing solvent to afford the title compound as a colorless oil (16.7 mg). 1H NMR (CDCI3): delta (ppm) 7.30-7.25 (m, 2 H), 7.19-7.14 (m, 1 H), 7.06 (d, 2 H, J = 7.3 Hz), 3.01 (m, 1 H), 2.31 (m, 1 H), 1.90 (m, 1 H), 1.87 (br. s, 1 H), 1.12 (d, 6 H, J = 6.3 Hz), 1.07 (m, 2 H). 13C NMR (CDCI3): delta (ppm) 142.8, 128.6 (2), 126.1 (2), 125.8, 49.7, 40.7, 25.9, 23.7, 23.6, 17.2. HRMS (ESI) calculated for Ci2H18N+ [MH+] 176.1439; found, 176.1437.

References: [1]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 35; 77-78.

35
[ 1986-47-6 ]
[ 129765-95-3 ]
C₁₉H₂₈N₂O₃ [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 2388 - 2399.

Precautionary Statements-General
Code	Phrase
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Prevention
Code	Phrase
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
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P234	Keep only in original container.
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Code	Phrase
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P321
P322
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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1986-47-6

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CAS No.: 1986-47-6

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Product Details of Tranylcypromine HCl

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Application In Synthesis of Tranylcypromine HCl

[ 1986-47-6 ] Synthesis Path-Downstream 1~35

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