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Chemical Structure| 81742-10-1 Chemical Structure| 81742-10-1
Chemical Structure| 81742-10-1

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3,6-Dichlorotrimellitic anhydride is the precursor of dichlorinated fluoresceins and rhodamines.

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Product Details of 3,6-Dichlorotrimellitic anhydride

CAS No. :81742-10-1
Formula : C9H2Cl2O5
M.W : 261.02
SMILES Code : O=C(O1)C2=C(Cl)C(C(O)=O)=CC(Cl)=C2C1=O
MDL No. :MFCD28962732
InChI Key :OCUQMPDZMXSVFG-UHFFFAOYSA-N
Pubchem ID :15883776

Safety of 3,6-Dichlorotrimellitic anhydride

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3,6-Dichlorotrimellitic anhydride

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81742-10-1 ]

[ 81742-10-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 58196-33-1 ]
  • [ 81742-10-1 ]
  • C27H20Cl2N2O5 [ No CAS ]
  • C27H20Cl2N2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With polyphosphoric acid; at 180℃; A mixture of compound 14 (1 g, 6.7 mmol) and 3,6-dichlorotrimellitic anhydride (875 mg, 3.35 mmol) in 5 mL polyphosphoric acid is heated to 180 C. overnight. After cooling to room temperature, the mixture is poured into ice/water, and stirred for 30 min. The resulting precipitate is filtered, washed with water, and dried under vacuum. The crude product is purified on silica gel using CH2Cl2/MeOH. Yield: 438 mg (25%).
  • 2
  • [ 58196-33-1 ]
  • [ 81742-10-1 ]
  • C27H18Cl2N2O11S2(2-) [ No CAS ]
  • C27H18Cl2N2O11S2(2-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: Place 5 mL fuming H2SO4 in a 50 mL round bottom flask and cool in an ice/water bath. Compound 11 (200 mg, 0.45 mmol) is added, and the reaction mixture is stirred at 0 C. until TLC shows complete consumption of compound 11. The mixture is added to the stirring Et2O solution (300 mL) at 0 C. The resulting precipitate is filtered, washed with EtOAc, and dried. The crude product is purified by RP-HPLC using TEAA/ACN to give compound 1a (90 mg, 25%) and compound 1b (98 mg, 27%).
 

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