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CAS No. :	13466-43-8
Formula :	C₅H₄BrNO
M.W :	174.00
SMILES Code :	O=C1C(Br)=CC=CN1
MDL No. :	MFCD03411569
InChI Key :	YDUGVOUXNSWQSW-UHFFFAOYSA-N
Pubchem ID :	818549

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
72%		Example 19A3-Bromo-1-(2-methoxy-4-nitrophenyl)pyridin-2(1H)-one 70 g (403 mmol) of 3-bromopyridin-2(1H)-one are dissolved in 1 l of anhydrous dimethyl sulphoxide, and 54 g (484 mmol) of potassium tert-butoxide are added at room temperature. The suspension is stirred at this temperature for 1 h. 69 g (403 mmol) of <strong>[454-16-0]1-fluoro-2-methoxy-4-nitrobenzene</strong> are added, and the reaction solution is heated at 80° C. for 20 h. Carefully, the mixture is diluted with 5 l of water. The precipitated solid is filtered off, washed with water and dried under reduced pressure. This gives 103 g (72percent of theory) of the desired product.1H-NMR (400 MHz, DMSO-d6, delta/ppm): delta=8.05 (dd, 1H), 8.1 (d, 1H), 7.95 (dd, 1H), 7.7 (d, 1H), 7.6 (dd, 1H), 6.3 (t, 1H), 3.9 (s, 3H).MS (ESIpos): m/z=342 (M+NH4)+
	With potassium tert-butylate; In water; dimethyl sulfoxide;	Example 28A 3-Bromo-1-(2-methoxy-4-nitrophenyl)pyridin-2(1H)-one 70 g (403 mmol) of 3-bromopyridin-2(1H)-one are dissolved in 1 l of anhydrous dimethyl sulphoxide, and 54 g (484 mmol) of potassium tert-butoxide are added at room temperature. The suspension is stirred at this temperature for 1 h. 69 g (403 mmol) of <strong>[454-16-0]1-fluoro-2-methoxy-4-nitrobenzene</strong> are added, and the reaction solution is heated at 80° C. for 20 h. Carefully, the mixture is diluted with 5 l of water. The precipitated solid is filtered off, washed with water and dried under reduced pressure. This gives 103 g (72percent of theory) of the desired product. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): delta=8.05 (dd, 1H), 8.1 (d, 1H), 7.95 (dd, 1H), 7.7 (d, 1H), 7.6 (dd, 1H), 6.3 (t, 1H), 3.9 (s, 3H). MS (ESIpos): m/z=342 (M-FNH4)+
38.7 g	With potassium phosphate; In 1-methyl-pyrrolidin-2-one; at 120℃; for 6h;	Example 5 Preparation of 3-bromo-1-(2-methoxy-4-nitrophenyl)pyridin-2(1H)-one 36.2 g of 3-bromopyridone (87percent purity, 0.18 mol) and 29.4 g of <strong>[454-16-0]<strong>[454-16-0]4-fluoro-3-methoxynitrobenze</strong>ne</strong> (0.17 mol) were introduced as initial charge in 180 ml of N-methylpyrrolidone; 46.1 g of anhydrous potassium phosphate (0.22 mol) were added and the reaction mixture was carried out at 120° C. for 6 h. After cooling to 90° C., water was added and the mixture was cooled to room temperature. The precipitate was filtered off, washed with water and stirred with a methanol/water mixture (1:1). The solid was filtered off, washed and dried in the air. This gave 38.7 g (66percent) of the desired target compound.[0098] HPLC (method 3): Rt=3.50 min. [0099] LC-MS (method 4): Rt=0.84 min. [0100] 1H NMR (400 MHz, DMSO-d6): delta [ppm]=3.91 (s, 3H), 6.30 (t, 1H), 7.64 (dd, 1H), 7.70 (d, 1H), 7.96 (dd, 1H), 8.00 (m, 1H), 8.04 (dd, 1H). [0101] MS (ES+): [M+H]+ 327 or 325.

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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
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P260	Do not breathe dust/fume/gas/mist/vapours/spray.
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Code	Phrase
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P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P401
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Disposal
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CAS No.: 13466-43-8

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CAS No.: 13466-43-8

Alternative Products

Product Details of 3-Bromopyridin-2-ol

Safety of 3-Bromopyridin-2-ol

Application In Synthesis of 3-Bromopyridin-2-ol

[ 13466-43-8 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed