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Chemical Structure| 6066-49-5 Chemical Structure| 6066-49-5

Structure of 3-Butylphthalide
CAS No.: 6066-49-5

Chemical Structure| 6066-49-5

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Butylphthalide, a natural product isolated and purified from the herbs of Ligusticum jeholense with antihypertensive effects, may slow the progression of hypertensive nephropathy by a variety of mechanisms, and is effective for improving cognitive and global functioning in patients with subcortical VCIND and exhibits good safety.

Synonyms: Butylphthalide; 3-n-Butylphthalide; rac-3-n-butylphthalide.

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Product Details of 3-Butylphthalide

CAS No. :6066-49-5
Formula : C12H14O2
M.W : 190.24
SMILES Code : O=C1OC(CCCC)C2=C1C=CC=C2
Synonyms :
Butylphthalide; 3-n-Butylphthalide; rac-3-n-butylphthalide.
MDL No. :MFCD01704513
InChI Key :HJXMNVQARNZTEE-UHFFFAOYSA-N
Pubchem ID :61361

Safety of 3-Butylphthalide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human lung adenocarcinoma PC9 cells 100 and 1000 μmol/L 24 hours To detect the phosphorylation levels of PI3K and AKT and the expression level of VEGF. The results showed that Chuanxiong treatment significantly reduced the phosphorylation levels of PI3K and AKT and the level of VEGF (P<0.01). PMC8526315

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02594995 Cerebrovascular Occlusion|Coll... More >>ateral Blood Circulation|Anterior Cerebral Circulation Infarction Less << PHASE4 COMPLETED 2019-12-30 The second affiliated hospital... More >> of Zhejiang University, Hangzhou, Zhejiang, 310000, China Less <<
NCT05068349 Stroke|Cerebral Infarction|Bra... More >>in Infarction|Brain Ischemia|Nervous System Diseases|Central Nervous System Diseases|Vascular Diseases Less << PHASE4 RECRUITING 2025-12-25 Shandong Provincial Qianfoshan... More >> Hospital, Jinan, Shandong Provincial, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.26mL

1.05mL

0.53mL

26.28mL

5.26mL

2.63mL

52.57mL

10.51mL

5.26mL

References

[1]Jia J, Wei C, et al. The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial. Alzheimers Dement. 2016 Feb;12(2):89-99.

[2]Zhu J, Zhang Y, Yang C. Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. Mol Med Rep. 2015 Feb;11(2):1448-54.

[3]Abdoulaye IA, Guo YJ. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. Biomed Res Int. 2016;2016:5012341

[4]Bu X, Xia W, Wang X, Lu S, Gao Y. Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK/p38 MAPK signaling pathway. Exp Ther Med. 2021 Jun;21(6):565

[5]Zhan L, Pang Y, Jiang H, Zhang S, Jin H, Chen J, Jia C, Guo H, Mu Z. Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect. J Healthc Eng. 2022 Jan 7;2022:4687349

[6]Wang Y, Yao W, Wang L, Xv D. The effect of butylphthalide injection on the cognitive function and the TLRs/NF-κB pathway in hypertensive intracerebral hemorrhage. Am J Transl Res. 2021 Aug 15;13(8):9578-9585

[7]Xiong Y, Liu J, Xu Y, Xie S, Zhou X, Cheng S. Butylphthalide Combined With Conventional Treatment Attenuates MMP-9 Levels and Increases VEGF Levels in Patients With Stroke: A Prospective Cohort Study. Front Neurol. 2021 Dec 20;12:686199

[8]Zhao W, Luo C, Wang J, Gong J, Li B, Gong Y, Wang J, Wang H. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26

 

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