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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 771-51-7 Chemical Structure| 771-51-7

Structure of 3-Indoleacetonitrile
CAS No.: 771-51-7

Chemical Structure| 771-51-7

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3-Indoleacetonitrile, a plant growth hormone, is a light-induced auxin-inhibitory substance that is isolated from light-grown cabbage (Brassica olearea L.) shoots.

4.5 *For Research Use Only !

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Product Details of 3-Indoleacetonitrile

CAS No. :771-51-7
Formula : C10H8N2
M.W : 156.18
SMILES Code : N#CCC1=CNC2=C1C=CC=C2
MDL No. :MFCD00005628
InChI Key :DMCPFOBLJMLSNX-UHFFFAOYSA-N
Pubchem ID :351795

Safety of 3-Indoleacetonitrile

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P501-P261-P270-P271-P264-P280-P361+P364-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Class:6.1
UN#:3439
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Serratia marcescens ATCC 14756 1 mM 20 h Inhibited biofilm formation, swimming and swarming motility, and pigment production in S. marcescens. Front Microbiol. 2020 Oct 30;11:584812
Huh7.0 cells 80 μM, 160 μM, 320 μM 24 h To evaluate the antiviral effect of 3-indoleacetonitrile against SARS-CoV-2 virus. The results showed that 3-indoleacetonitrile significantly inhibited the replication of SARS-CoV-2 virus. Antiviral Res. 2023 Jan;209:105465
Caco-2 cells 320 μM, 640 μM, 1280 μM 24 h To evaluate the antiviral effect of 3-indoleacetonitrile against SARS-CoV-2 virus. The results showed that 3-indoleacetonitrile significantly inhibited the replication of SARS-CoV-2 virus. Antiviral Res. 2023 Jan;209:105465
Vero E6 cells 640 μM 24 h To evaluate the antiviral effect of 3-indoleacetonitrile against VSV virus. The results showed that 3-indoleacetonitrile significantly inhibited the replication of VSV virus. Antiviral Res. 2023 Jan;209:105465
293T cells 640 μM 24 h To evaluate the antiviral effect of 3-indoleacetonitrile against VSV virus. The results showed that 3-indoleacetonitrile significantly inhibited the replication of VSV virus. Antiviral Res. 2023 Jan;209:105465

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice SARS-CoV-2 infection model Tail vein injection 20 mg/kg Administered on days 0, 2, and 4 post-infection, observed for 10 days To evaluate the antiviral effect of 3-indoleacetonitrile against SARS-CoV-2 infection. The results showed that 3-indoleacetonitrile significantly reduced weight loss, improved survival rate, and reduced lung lesions in mice. Antiviral Res. 2023 Jan;209:105465

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.40mL

1.28mL

0.64mL

32.01mL

6.40mL

3.20mL

64.03mL

12.81mL

6.40mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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