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Chemical Structure| 621-44-3 Chemical Structure| 621-44-3
Chemical Structure| 621-44-3

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3-Nitro-L-tyrosine is a tyrosine derivative with a nitro group that inhibits certain enzymes.

Synonyms: Nitrotyrosine; 3-NT; MNT

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Product Citations

Product Citations

Zhou, Bin ; Shetye, Gauri ; Yu, Yang ; Santarsiero, Bernard D. ; Klein, Larry L. ; Abad-Zapatero, Cele , et al.

Abstract: This study represents a systematic chem. and biol. study of the rufomycin (RUF) class of cyclic heptapeptides, which our anti-TB drug discovery efforts have identified as potentially promising anti-TB agents that newly target the caseinolytic protein C1, ClpC1. Eight new RUF analogs, rufomycins NBZ1-NBZ8, as well as 5 known peptides were isolated and characterized from the Streptomyces atratus strain MJM3502. Advanced Marfey's and X-ray crystallog. anal. led to the assignment of the absolute configuration of the RUFs. Several isolates exhibited potent activity against both pathogens M. tuberculosis H37Rv and M. abscessus, paired with favorable selectivity (selectivity index >60), which collectively underscores the promise of the rufomycins as potential anti-TB drug leads.

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Product Details of 3-Nitro-L-tyrosine

CAS No. :621-44-3
Formula : C9H10N2O5
M.W : 226.19
SMILES Code : N[C@@H](CC1=CC([N+]([O-])=O)=C(C=C1)O)C(O)=O
Synonyms :
Nitrotyrosine; 3-NT; MNT
MDL No. :MFCD00007123
InChI Key :FBTSQILOGYXGMD-LURJTMIESA-N
Pubchem ID :65124

Safety of 3-Nitro-L-tyrosine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338
 

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