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Chemical Structure| 303224-30-8 Chemical Structure| 303224-30-8

Structure of 303224-30-8

Chemical Structure| 303224-30-8

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Product Details of [ 303224-30-8 ]

CAS No. :303224-30-8
Formula : C10H7ClFNO
M.W : 211.62
SMILES Code : FC1=CC(C2=NC(CCl)=CO2)=CC=C1
MDL No. :MFCD09971344

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Application In Synthesis of [ 303224-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 303224-30-8 ]

[ 303224-30-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 455-37-8 ]
  • [ 534-07-6 ]
  • [ 303224-30-8 ]
YieldReaction ConditionsOperation in experiment
39% In toluene; at 100℃; for 5h; 1,3-Dichloroacetone (3.65 g, 28.75 mmol) was added to a solution of <strong>[455-37-8]3-fluorobenzamide</strong> (2 g, 14.37 mmol) in dry toluene (20 mL). The resulting reaction mixture was stirred at 100 C for 5 h. The reaction mixture was concentrated under reduced pressure and the crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 10% EtOAc in petroleum ether) to afford 4-(chloromethyl)-2-(3-fluorophenyl)oxazole (1.2 g, yield 39%) as a yellow liquid. 1H NMR (300 MHz, CDCl3) delta 7.85 - 7.83 (m, 1 H), 7.77 - 7.73 (m, 2H), 7.48 - 7.41 (m, 1 H), 7.20 - 7.14 (m, 1 H), 4.58 (d, J = 0.9 Hz, 2H).
 

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