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Chemical Structure| 30414-37-0 Chemical Structure| 30414-37-0

Structure of 30414-37-0

Chemical Structure| 30414-37-0

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Product Details of [ 30414-37-0 ]

CAS No. :30414-37-0
Formula : C6H12O2
M.W : 116.16
SMILES Code : OC1OC(C)(C)CC1

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Application In Synthesis of [ 30414-37-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30414-37-0 ]

[ 30414-37-0 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 3123-97-5 ]
  • [ 30414-37-0 ]
YieldReaction ConditionsOperation in experiment
With diisobutylaluminium hydride; In tetrahydrofuran; at -78℃; for 3h;Inert atmosphere; Step 1. Preparation of 5,5-dimethyltetrahydrofuran-2-ol DIBAL (1.314 mL, 1.314 mmol) was added to a solution of 5,5-dimethyldihydrofuran- 2(3H)-one (100 mg, 0.876 mmol) in THF (10 mL) under nitrogen at -78 °C. The reaction mixture was stirred at -78 °C for 3 h. A solution of Rochelle's salt was added to the reaction mixture, which was stirred at rt for 30 min. The reaction mixture was partitioned between EtOAc and water. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under vacuum to afford the crude product (35 mg, 0.301 mmol, 34percent yield). ^- MR of the crude product showed that it was in equilibrium between 4-hydroxy-4-methylpentanal and 5,5-dimethyltetrahydrofuran-2-ol with 5,5- dimethyltetrahydrofuran-2-ol (35 mg, 0.301 mmol, 34percent yield) being the predominant form. 1H NMR (400MHz, CHLOROFORM-d) delta 5.51 (d, J=4.8 Hz, 1H), 2.90 (br. s., 1H), 2.03 - 1.94 (m, 2H), 1.82 - 1.64 (m, 2H), 1.43 (s, 3H), 1.22 (s, 3H).
 

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