Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	30608-63-0
Formula :	C₄H₁₁NO
M.W :	89.14
SMILES Code :	CC[C@@H](CN)O
English Name :	(S)-1-Aminobutan-2-ol
MDL No. :	MFCD00079691
InChI Key :	KODLUXHSIZOKTG-BYPYZUCNSA-N
Pubchem ID :	6995554

GHS Pictogram:
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Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; sodium hydroxide; sodium tris(acetoxy)borohydride	a Prodution of tert-butyl (S)-(2-hydroxybutyl)((8-hydroxyquinolin-7-yl)methyl)carbamate Reference Example 27-(a) Prodution of tert-butyl (S)-(2-hydroxybutyl)((8-hydroxyquinolin-7-yl)methyl)carbamate A solution of 8-hydroxyquinoline-7-carbaldehyde (400 mg) and (2S)-1-amino-2-butanol (0.24 mL) in dichloromethane (12 mL) was stirred under argon gas flow at room temperature for 30 minutes. Then, sodium triacetoxyborohydride (734 mg) was added thereto, and the resulting mixture was stirred at room temperature for 10 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, to the resulting residues were added methanol (4 mL) and a 8 M aqueous solution of sodium hydroxide (2.89 mL), di-tert-butyl dicarbonate (1.06 mL) was added thereto, and the resulting mixture was stirred at room temperature for 3 hours. Additionally, di-tert-butyl dicarbonate (1.06 mL) was added thereto, and the resulting mixture was stirred at room temperature for 1 hour. Additionally, a 8 M aqueous solution of sodium hydroxide (0.7 mL) was added thereto, and the resulting mixture was stirred at room temperature for 2 hours. 1 M hydrochloric acid was added thereto to adjust the pH to 6.5, and the resulting mixture was subjected to extraction with ethyl acetate. The resulting organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The resulting residues were purified by a silica gel column (DIOL silica gel, elution solvent; hexane : ethyl acetate) to give the title compound (474 mg) as a slightly yellow oil. Mass spectrum (ESI, m/z): 347 [M+H]+
474 mg	Stage #1: (S)-(+)-1-amino-2-butanol; 8-hydroxy-7-quinolinecarboxaldehyde In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 10h; Stage #3: di-<i>tert</i>-butyl dicarbonate With sodium hydroxide In methanol; lithium hydroxide monohydrate at 20℃; for 6h;	27-(a) Prodution of tert-butyl (S)-(2-hydroxybutyl)((8-hydroxyquinolin-7-yl)methyl)carbamate A solution of 8-hydroxyquinoline-7-carbaldehyde (400 mg) and (2S)-1-amino-2-butanol (0.24 mL) in dichloromethane (12 mL) was stirred under argon gas flow at room temperature for 30 minutes. Then, sodium triacetoxyborohydride (734 mg) was added thereto, and the resulting mixture was stirred at room temperature for 10 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, to the resulting residues were added methanol (4 mL) and a 8 M aqueous solution of sodium hydroxide (2.89 mL), di-tert-butyl dicarbonate (1.06 mL) was added thereto, and the resulting mixture was stirred at room temperature for 3 hours. Additionally, di-tert-butyl dicarbonate (1.06 mL) was added thereto, and the resulting mixture was stirred at room temperature for 1 hour. Additionally, a 8 M aqueous solution of sodium hydroxide (0.7 mL) was added thereto, and the resulting mixture was stirred at room temperature for 2 hours. 1 M hydrochloric acid was added thereto to adjust the pH to 6.5, and the resulting mixture was subjected to extraction with ethyl acetate. The resulting organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The resulting residues were purified by a silica gel column (DIOL silica gel, elution solvent; hexane : ethyl acetate) to give the title compound (474 mg) as a slightly yellow oil. Mass spectrum (ESI, m/z): 347 [M+H]+

Precautionary Statements-General
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P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
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P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
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P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
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P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
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P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
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P411 + P235	Keep cool.
Disposal
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P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 30608-63-0

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CAS No.: 30608-63-0

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Application In Synthesis of [ 30608-63-0 ]

[ 30608-63-0 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed