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Chemical Structure| 3081-24-1 Chemical Structure| 3081-24-1

Structure of 3081-24-1

Chemical Structure| 3081-24-1

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Product Details of [ 3081-24-1 ]

CAS No. :3081-24-1
Formula : C11H15NO2
M.W : 193.24
SMILES Code : N[C@@H](CC1=CC=CC=C1)C(OCC)=O

Safety of [ 3081-24-1 ]

Application In Synthesis of [ 3081-24-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3081-24-1 ]

[ 3081-24-1 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 3081-24-1 ]
  • [ 108-24-7 ]
  • [ 2361-96-8 ]
  • 3
  • [ 108-22-5 ]
  • [ 3081-24-1 ]
  • [ 2361-96-8 ]
  • 4
  • [ 3081-24-1 ]
  • [ 2361-96-8 ]
  • 5
  • [ 3081-24-1 ]
  • [ 64-19-7 ]
  • [ 2361-96-8 ]
  • (R)-ethyl N-acetylphenylalanine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With (1-methyl-3-(3-sulfopropyl)-1H-imidazol-3-ium)3[PW12O403-]; In neat (no solvent); at 100℃; for 0.116667h;Green chemistry; General procedure: To a mixture of amine (2 mmol) and carboxylic acid (6 mmol) in a 10 mL round bottomed flask was added [MIMPS]3PW12O40 (140 mg, 0.04 mmol). The reaction mixture was stirred at 100 C. The progress of the reaction was monitored by TLC. On completion, the mixture was diluted with ethyl acetate (20 mL) with stirring for 30 min. The insoluble catalyst was recovered by filtration. The filtrate was washed with satd solution of NaHCO3 (5 mL×3), brine, and dried over anhyd Na2SO4. The solvent was evaporated and the residue in almost pure form. Recrystallization or column chromatography could be used for further purification.
  • 6
  • [ 924-44-7 ]
  • [ 3081-24-1 ]
  • [ 13380-67-1 ]
  • diethyl (1S,3R,3aS,6aR)-1-benzyl-5-(4-bromophenyl)-4,6-dioxooctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
98% With (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); silver carbonate; In toluene; at -10℃; for 24h;Darkness; General procedure: In a 10 ml vial covered by aluminum foil, Ag2CO3 (6.9 mg, 0.025 mmol), (S)-binap 6 (31 mg, 0.050 mmol), and toluene (3 mL) were added and the resulting mixture was stirred at room temperature for 1 h. The mixture was cooled at -10C and the amino ester 2c (193 mg, 1 mmol), the corresponding maleimide 3 (1 mmol), and ethyl glyoxylate 1 (ca. 50% solution in toluene, 102 μL, 1.2 mmol)were slowly added in this order. The reaction was stirred for 1 d at -10C and the crude was analyzed by 1H NMR spectroscopy to determine the conversion, and then purified by flash chromatography (n-hexane/EtOAc) to afford cycloadducts 4.
  • 7
  • [ 3081-24-1 ]
  • [ 507-09-5 ]
  • [ 2361-96-8 ]
 

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