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CAS No.: 3094-09-5
                                    
                                
 
                                 
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                            The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.
Synonyms: 5'-DFUR; 5-Fluoro-5'-deoxyuridine; 5'-Deoxy-5-fluorouridine
 
                
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        					 *For Research Use Only !
        				
        				*For Research Use Only !
        			
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| CAS No. : | 3094-09-5 | 
| Formula : | C9H11FN2O5 | 
| M.W : | 246.19 | 
| SMILES Code : | C[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(F)=C2)=O)=O)O1)O)O | 
| Synonyms : | 
                                5'-DFUR; 5-Fluoro-5'-deoxyuridine; 5'-Deoxy-5-fluorouridine
                             | 
| MDL No. : | MFCD00866530 | 
| GHS Pictogram: |   | 
| Signal Word: | Warning | 
| Hazard Statements: | H315-H319-H335 | 
| Precautionary Statements: | P261-P305+P351+P338 | 
In Vitro:
| Cell Line | Concentration | Treated Time | Description | References | 
| Human gut microbiota | 500 µM | 6, 12, 24 hours | To evaluate the inter-individual differences in metabolism of Doxifluridine by gut microbiota, showing significant variations in 5-FU production among donors | ISME Commun. 2023 Apr 25;3(1):38. | 
In Vivo:
| Species | Animal Model | Administration | Dosage | Frequency | Description | References | 
| BALB/c mice | Colon cancer model | Oral | 400 mg/kg | Administered on day 1 and day 5 | To evaluate the antitumor effect of Doxifluridine in vivo on colon cancer cells. Results showed that Doxifluridine significantly reduced the proliferation of Colo320TP1 cells (down to 25-40%), but was less effective in Colo320 cells. | Br J Cancer. 2007 Jan 15;96(1):61-6 | 
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations | 
| NCT02494596 | - | Completed | - | - | |
| NCT00842244 | Stomach Neoplasms ... More >> Advanced Gastric Cancer Less << | Phase 1 | Completed | - | Japan ... More >> Pfizer Investigational Site Kashiwa, Chiba, Japan Pfizer Investigational Site Yufu-city, Oita, Japan Korea, Republic of Pfizer Investigational Site Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769 Pfizer Investigational Site Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Pfizer Investigational Site Seoul, Korea, Republic of, 110-744 Less << | 
| NCT00925769 | Pancreatic Cancer | Phase 1 | Completed | - | Austria ... More >> Vienna, Austria, 1100 Wien, Austria, 1130 Less << | 
| NCT02494596 | Solid Tumor | Phase 1 | Completed | - | Spain ... More >> Barcelona, Spain, 08036 United Kingdom Manchester, United Kingdom, M20 4BX Less << | 
| NCT00925769 | - | Completed | - | - | |
| NCT00842244 | - | Completed | - | - | |
| NCT00555620 | Stomach Neoplasms | Phase 1 | Completed | - | Korea, Republic of ... More >> Pfizer Investigational Site Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Pfizer Investigational Site Goyang, Gyeonggi, Korea, Republic of, 410-769 Pfizer Investigational Site Seoul, Korea, Republic of, 110-744 Less << | 
| NCT00662025 | Advanced/Metastatic Breast Can... More >>cer Less << | Phase 2 | Completed | - | Japan ... More >> Pfizer Investigational Site Anjo-city, Aichi, Japan Pfizer Investigational Site Nagoya, Aichi, Japan Pfizer Investigational Site Okazaki-City, Aichi, Japan Pfizer Investigational Site Toyoake, Aichi, Japan Pfizer Investigational Site Matsuyama-shi, Ehime, Japan Pfizer Investigational Site Kure, Hiroshima, Japan Pfizer Investigational Site Morioka, Iwate, Japan Pfizer Investigational Site Yokohama, Kanagawa, Japan Pfizer Investigational Site Sakai, Osaka, Japan Pfizer Investigational Site Bunkyo-ku, Tokyo, Japan Pfizer Investigational Site Koto-ku, Tokyo, Japan Pfizer Investigational Site Chiba, Japan Pfizer Investigational Site Fukuoka, Japan Pfizer Investigational Site Kagoshima, Japan Pfizer Investigational Site Kyoto, Japan Pfizer Investigational Site Niigata, Japan Pfizer Investigational Site Osaka, Japan Less << | 
| NCT00555620 | - | Completed | - | - | |
| NCT00532948 | Glioma | Phase 1 | Completed | - | United States, California ... More >> San Francisco, California, United States, 94143-0780 United States, District of Columbia Washington, District of Columbia, United States, 20010 United States, Illinois Chicago, Illinois, United States, 60614 United States, Massachusetts Boston, Massachusetts, United States, 02115-6084 United States, North Carolina Durham, North Carolina, United States, 27710 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Pittsburgh, Pennsylvania, United States, 15261 United States, Texas Houston, Texas, United States, 77030 United States, Washington Seattle, Washington, United States, 98105 Less << | 
| NCT00169000 | Metastatic Breast Cancer | Phase 1 | Completed | - | United States, New Hampshire ... More >> Norris Cotton Cancer Center Lebanon, New Hampshire, United States, 03756 Less << | 
| NCT02368860 | Pancreatic Cancer | Phase 1 | Recruiting | June 2019 | Singapore ... More >> National Cancer Centre Recruiting Singapore, Singapore, 169610 Contact: Lanying Wang 64368267 nctwly@nccs.com.sg Less << | 
| NCT00812864 | Breast Cancer ... More >> Colorectal Cancer Less << | Phase 4 | Completed | - | France ... More >> CHU Limoges Limoges Cedex, Province, France, 87042 Less << | 
| NCT00858429 | Liver Cancer ... More >>Metastatic Cancer Less << | Phase 1 | Active, not recruiting | December 2018 | United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 Less << | 
| NCT00353262 | Colorectal Cancer | Phase 1 | Completed | - | Canada, Ontario ... More >> Hamilton, Ontario, Canada, L8V 5C2 Ottawa, Ontario, Canada, K1H 8L6 Toronto, Ontario, Canada, M5G 2M9 Less << | 
| NCT03465202 | Breast Cancer ... More >> Colorectal Cancer Less << | Phase 4 | Not yet recruiting | November 2019 | - | 
| NCT00662025 | - | Completed | - | - | |
| NCT00296335 | Stomach Cancer | Phase 3 | Completed | - | Korea, Republic of ... More >> Asan Medical Center Seoul, Korea, Republic of, 138-736 Less << | 
| NCT00296322 | Stomach Cancer | Phase 3 | Completed | - | Korea, Republic of ... More >> Asan Medical Center Seoul, Korea, Republic of, 138-736 Less << | 
| NCT00353262 | - | Completed | - | - | |
| NCT00296322 | - | Completed | - | - | |
| NCT00532948 | - | Completed | - | - | |
| NCT00296335 | - | Completed | - | - | |
| NCT01401075 | Gastric Cancer | Phase 4 | Completed | - | Korea, Republic of ... More >> ASAN Medical Center Seoul, Korea, Republic of, 138-736 Less << | 
| Bio Calculators | ||||
| Preparing Stock Solutions |  | 1mg | 5mg | 10mg | 
| 1 mM 5 mM 10 mM | 4.06mL 0.81mL 0.41mL | 20.31mL 4.06mL 2.03mL | 40.62mL 8.12mL 4.06mL | |
Tags: Doxifluridine | Ro 21-9738 | 5-Fluoro-5'-deoxyuridine | 5'-DFUR | Thymidylate Synthase | Cervical cancer | colon cancer | 5-FU | 5-dFUR | BALB ? cA Jcl-nu | FU-MMT-1 | 3094-09-5
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