Home Cart Sign in  
Chemical Structure| 3094-09-5 Chemical Structure| 3094-09-5

Structure of Doxifluridine
CAS No.: 3094-09-5

Chemical Structure| 3094-09-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.

Synonyms: 5'-DFUR; 5-Fluoro-5'-deoxyuridine; 5'-Deoxy-5-fluorouridine

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Doxifluridine

CAS No. :3094-09-5
Formula : C9H11FN2O5
M.W : 246.19
SMILES Code : C[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(F)=C2)=O)=O)O1)O)O
Synonyms :
5'-DFUR; 5-Fluoro-5'-deoxyuridine; 5'-Deoxy-5-fluorouridine
MDL No. :MFCD00866530

Safety of Doxifluridine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human gut microbiota 500 µM 6, 12, 24 hours To evaluate the inter-individual differences in metabolism of Doxifluridine by gut microbiota, showing significant variations in 5-FU production among donors ISME Commun. 2023 Apr 25;3(1):38.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice Colon cancer model Oral 400 mg/kg Administered on day 1 and day 5 To evaluate the antitumor effect of Doxifluridine in vivo on colon cancer cells. Results showed that Doxifluridine significantly reduced the proliferation of Colo320TP1 cells (down to 25-40%), but was less effective in Colo320 cells. Br J Cancer. 2007 Jan 15;96(1):61-6

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02494596 - Completed - -
NCT00842244 Stomach Neoplasms ... More >> Advanced Gastric Cancer Less << Phase 1 Completed - Japan ... More >> Pfizer Investigational Site Kashiwa, Chiba, Japan Pfizer Investigational Site Yufu-city, Oita, Japan Korea, Republic of Pfizer Investigational Site Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769 Pfizer Investigational Site Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Pfizer Investigational Site Seoul, Korea, Republic of, 110-744 Less <<
NCT00925769 Pancreatic Cancer Phase 1 Completed - Austria ... More >> Vienna, Austria, 1100 Wien, Austria, 1130 Less <<
NCT02494596 Solid Tumor Phase 1 Completed - Spain ... More >> Barcelona, Spain, 08036 United Kingdom Manchester, United Kingdom, M20 4BX Less <<
NCT00925769 - Completed - -
NCT00842244 - Completed - -
NCT00555620 Stomach Neoplasms Phase 1 Completed - Korea, Republic of ... More >> Pfizer Investigational Site Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Pfizer Investigational Site Goyang, Gyeonggi, Korea, Republic of, 410-769 Pfizer Investigational Site Seoul, Korea, Republic of, 110-744 Less <<
NCT00662025 Advanced/Metastatic Breast Can... More >>cer Less << Phase 2 Completed - Japan ... More >> Pfizer Investigational Site Anjo-city, Aichi, Japan Pfizer Investigational Site Nagoya, Aichi, Japan Pfizer Investigational Site Okazaki-City, Aichi, Japan Pfizer Investigational Site Toyoake, Aichi, Japan Pfizer Investigational Site Matsuyama-shi, Ehime, Japan Pfizer Investigational Site Kure, Hiroshima, Japan Pfizer Investigational Site Morioka, Iwate, Japan Pfizer Investigational Site Yokohama, Kanagawa, Japan Pfizer Investigational Site Sakai, Osaka, Japan Pfizer Investigational Site Bunkyo-ku, Tokyo, Japan Pfizer Investigational Site Koto-ku, Tokyo, Japan Pfizer Investigational Site Chiba, Japan Pfizer Investigational Site Fukuoka, Japan Pfizer Investigational Site Kagoshima, Japan Pfizer Investigational Site Kyoto, Japan Pfizer Investigational Site Niigata, Japan Pfizer Investigational Site Osaka, Japan Less <<
NCT00555620 - Completed - -
NCT00532948 Glioma Phase 1 Completed - United States, California ... More >> San Francisco, California, United States, 94143-0780 United States, District of Columbia Washington, District of Columbia, United States, 20010 United States, Illinois Chicago, Illinois, United States, 60614 United States, Massachusetts Boston, Massachusetts, United States, 02115-6084 United States, North Carolina Durham, North Carolina, United States, 27710 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Pittsburgh, Pennsylvania, United States, 15261 United States, Texas Houston, Texas, United States, 77030 United States, Washington Seattle, Washington, United States, 98105 Less <<
NCT00169000 Metastatic Breast Cancer Phase 1 Completed - United States, New Hampshire ... More >> Norris Cotton Cancer Center Lebanon, New Hampshire, United States, 03756 Less <<
NCT02368860 Pancreatic Cancer Phase 1 Recruiting June 2019 Singapore ... More >> National Cancer Centre Recruiting Singapore, Singapore, 169610 Contact: Lanying Wang    64368267    nctwly@nccs.com.sg Less <<
NCT00812864 Breast Cancer ... More >> Colorectal Cancer Less << Phase 4 Completed - France ... More >> CHU Limoges Limoges Cedex, Province, France, 87042 Less <<
NCT00858429 Liver Cancer ... More >>Metastatic Cancer Less << Phase 1 Active, not recruiting December 2018 United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 Less <<
NCT00353262 Colorectal Cancer Phase 1 Completed - Canada, Ontario ... More >> Hamilton, Ontario, Canada, L8V 5C2 Ottawa, Ontario, Canada, K1H 8L6 Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT03465202 Breast Cancer ... More >> Colorectal Cancer Less << Phase 4 Not yet recruiting November 2019 -
NCT00662025 - Completed - -
NCT00296335 Stomach Cancer Phase 3 Completed - Korea, Republic of ... More >> Asan Medical Center Seoul, Korea, Republic of, 138-736 Less <<
NCT00296322 Stomach Cancer Phase 3 Completed - Korea, Republic of ... More >> Asan Medical Center Seoul, Korea, Republic of, 138-736 Less <<
NCT00353262 - Completed - -
NCT00296322 - Completed - -
NCT00532948 - Completed - -
NCT00296335 - Completed - -
NCT01401075 Gastric Cancer Phase 4 Completed - Korea, Republic of ... More >> ASAN Medical Center Seoul, Korea, Republic of, 138-736 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.31mL

4.06mL

2.03mL

40.62mL

8.12mL

4.06mL

References

 

Historical Records

Categories