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CAS No. : | 3125-64-2 | MDL No. : | MFCD00040335 |
Formula : | C8H7NOS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | WHBYCPUKGYEYFU-UHFFFAOYSA-N |
M.W : | 165.21 | Pubchem ID : | 137832 |
Synonyms : |
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Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P280-P301+P310 | UN#: | 2810 |
Hazard Statements: | H301-H317 | Packing Group: | Ⅲ |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4.40 g (99%) | With potassium carbonate; In dichloromethane; acetone; | 1 2-Isopropylsulfonyl-3-(3-methoxyphenylamino)-3-methylsulfanyl-2-propenenitrile A solution of 2-propanesulfonylacetonitrile (2.0 g, 13.6 mmol) in dry acetone (25 ml) was stirred while dry potassium carbonate (1.28 g, 9.28 mmol) and 3-methoxyphenyl isothiocyanate (2.36 g, 14.3 mmol) were added. The resulting mixture was stirred at room temperature under nitrogen for 20 h. Excess of potassium carbonate was filtered off, methyl iodide (2.54 ml, 40.8 mmol) was added to the filtrate, and stirring was continued for 60 h. The mixture was evaporated and the residue was dissolved in dichloromethane and extracted with water and brine. The organic phase was dried over magnesium sulphate, filtered and evaporated to afford 4.40 g (99%) of the title compound as yellow crystals. Mp 107-110 C. 1H NMR (200 MHz, CDCl3): delta=1.44 (d, 6H), 2.22 (s, 3H), 3.36 (heptet, 1H), 3.83 (s, 3H), 6.81 (m, 1H), 6.85 (dd, 1H), 6.87 (dd, 1H), 7.32 (dd, 1H), 9.91 (br s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | To a stirred solution of potassium carbonate (84 mg, 0.605 mmol) in DMF (0.5 mL) was added methyl-3-cycloproyl-3-oxopropionate (0.07 mL, 0.6053 mmol). After stirring at rt for 2 h, 3-methoxyophenyl isothiocyanate (0.08 mL, 0.6053 mmol) was added at 0 C. Then, the mixture was stirred for 60 C for 2 h before addition of 2-(bromomethyl)pyridine hydrobromide (153 mg, 0.6053 mmol). The reaction mixture was stirred at 60 C for 3 h and extracted with ethyl acetate. The organic layer was dried over anhydrous Na2SO4, filtered and evaporated. The resulting crude residue was purified by column chromatography (ethyl acetate/Hex 10%) to give the thiophene 8ak (186 mg, 81% yield) a yellow liquid. |