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Chemical Structure| 321532-91-6 Chemical Structure| 321532-91-6

Structure of 321532-91-6

Chemical Structure| 321532-91-6

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Product Details of [ 321532-91-6 ]

CAS No. :321532-91-6
Formula : C13H11FN2O2S
M.W : 278.30
SMILES Code : O=C(NC1=NC(C)=C(C(C)=O)S1)C2=CC=C(F)C=C2
MDL No. :MFCD01351587

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Application In Synthesis of [ 321532-91-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 321532-91-6 ]

[ 321532-91-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 30748-47-1 ]
  • [ 456-22-4 ]
  • [ 321532-91-6 ]
YieldReaction ConditionsOperation in experiment
11% To a flask containing 4-fluorobenzoic acid (385 mg, 2.75 mmol) was added DMF (9 mL). CDI (446 mg, 2.75 mmol) was added and the reaction was stirred at room temperature for 15 min. At this point, 12 (391 mg 2.50 mmol) and additional DMF (4 mL) were added. The reaction was heated to 100 oC and stirred overnight. A solution of 1 M NaOH was added (10 mL), the mixture was poured into 100 mL of ice water, and the precipitate was collected by filtration. The crude material was absorbed onto celite using DMF and then purified by flash column chromatography (1% DMF in dichloromethane) to afford 17 (77 mg, 0.277 mmol, 11%) as an orange solid; MS (ESI) m/z calcd. 278.05, found 279.06 [M + H]+; Purity was determined to be 94.01% by HPLC analysis. Compound 17 was used immediately without full characterization. See 9 for characterization.
  • 2
  • [ 30748-47-1 ]
  • [ 403-43-0 ]
  • [ 321532-91-6 ]
YieldReaction ConditionsOperation in experiment
62% With triethylamine; In dichloromethane;Reflux; General procedure: 3-chloropentane-2,4-dione (1.0 equiv., 0.013 mmol)was refluxed with thiourea for 6-7 h (MeOH/H) whichyielded 1-(2-amino-4-methylthiazol-5-yl)ethenone andthen the yielded product was further refluxed with(Benzoyl chloride(R)) for 23 h (Et 3N CH2Cl2) whichlead to the formation of a parent compound that was(N-(5-acetyl-4-methylthiazol-2-yl)-4-(substituted)benzamide)(Table 1).
 

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