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Chemical Structure| 33007-28-2 Chemical Structure| 33007-28-2

Structure of 33007-28-2

Chemical Structure| 33007-28-2

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Product Details of [ 33007-28-2 ]

CAS No. :33007-28-2
Formula : C10H8ClN3O
M.W : 221.64
SMILES Code : CC(NC1=NC2=NC=CC(Cl)=C2C=C1)=O

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Application In Synthesis of [ 33007-28-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 33007-28-2 ]

[ 33007-28-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 39539-66-7 ]
  • 5-hydroxy-6-(5-methoxy-1,8-naphthyridin-2-yl)-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole [ No CAS ]
  • 6-(5-methoxy-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole [ No CAS ]
  • [ 33007-28-2 ]
YieldReaction ConditionsOperation in experiment
In N-methyl-acetamide; ice-water; EXAMPLE 24 Following the procedure of Example 17 but starting with 5-hydroxy-6-(5-methoxy-1,8-naphthyridin-2-yl)-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole (1.05 g.), sodium hydride (0.09 g.) and 1-chlorocarbonyl-4-methylpiperazine (1.0 g.) in anhydrous dimethylformamide (25 cc.), stirring the reaction mixture for 4 hours at 5C. and then diluting it with ice-water (200 cc.), 6-(5-methoxy-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole (0.23 g.), melting at 268C. after crystallisation from acetonitrile, is obtained. 5-Hydroxy-6-(5-methoxy-1,8-naphthyridin-2-yl)-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole employed as starting material can be obtained in the following way: Preparation of 2-acetylamino-5-chloro-1,8-naphthyridine, m.p. 265C, according to S.
 

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