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Chemical Structure| 33332-30-8 Chemical Structure| 33332-30-8

Structure of 33332-30-8

Chemical Structure| 33332-30-8

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Product Details of [ 33332-30-8 ]

CAS No. :33332-30-8
Formula : C5H5ClN2O
M.W : 144.56
SMILES Code : ClC1=NC(=CN=C1)OC
MDL No. :MFCD06410937
InChI Key :XWSSFRJLOZQOCX-UHFFFAOYSA-N
Pubchem ID :11018999

Safety of [ 33332-30-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Computational Chemistry of [ 33332-30-8 ] Show Less

Physicochemical Properties

Num. heavy atoms 9
Num. arom. heavy atoms 6
Fraction Csp3 0.2
Num. rotatable bonds 1
Num. H-bond acceptors 3.0
Num. H-bond donors 0.0
Molar Refractivity 33.53
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

35.01 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

1.49
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

1.65
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

1.14
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

-0.07
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

1.56
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

1.15

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-2.2
Solubility 0.906 mg/ml ; 0.00626 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-2.0
Solubility 1.45 mg/ml ; 0.01 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-2.37
Solubility 0.612 mg/ml ; 0.00424 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-6.01 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

1.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

0.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

2.37

Application In Synthesis of [ 33332-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 33332-30-8 ]

[ 33332-30-8 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 23902-69-4 ]
  • [ 33332-30-8 ]
  • [ 40155-28-0 ]
YieldReaction ConditionsOperation in experiment
25% for 2 h; Heating / reflux A mixture of 0.98 g (0.0078 moi) of 2-methoxy-pyrazine 4-oxide (Example P6) in 4 ml of phosphoryl chloride is stirred for 2 hours whilst heating at reflux, with 1.25 ml (0.0078 mol) of N, N-diethylaniline being metered in with the aid of a syringe before the start of the reaction. The resulting solution is cooled to 20°C and poured onto ice-water. After adjusting the mixture to pH 9 with 30 percent aqueous sodium hydroxide solution, extraction is carried out four times, using 10 ml of chloroform each time. The combined extracts are washed with 3N hydrochloric acid and saturated sodium chloride solution and are dried over sodium sulfate. A mixture of the desired target compound and of the isomeric 2-chloro-3-methoxy-pyrazine is obtained, which can be separated on a silica gel column (eluant : ethyl acetate/isohexane 1/8). The desired title compound is obtained in a yield of 0.29 g (25 percent of theory), and the isomeric 2-chloro-3-methoxy-pyrazine in a yield of 0.38 g (33 percent of theory). 'H NMR (300 MHz, CDC13) of the title compound: 8.143 ppm (s, 1H) ; 8.131 ppm (s, 1H) ; 3.988 ppm (s, 3H). 'H NMR (300 MHz, CDC13) of 2-chloro-3-methoxy-pyrazine : 8.031 ppm (d (J=2.7 Hz), 1 H) ; 7.937 ppm (d (J=2.7 Hz), 1 H) ; 4.057 ppm (s, 3H).
References: [1] Patent: WO2003/87067, 2003, A1, . Location in patent: Page/Page column 39.
  • 2
  • [ 23902-69-4 ]
  • [ 33332-31-9 ]
  • [ 33332-30-8 ]
  • [ 40155-28-0 ]
References: [1] Journal of Heterocyclic Chemistry, 1994, vol. 31, # 5, p. 1177 - 1180.
[2] Journal of Heterocyclic Chemistry, 1994, vol. 31, # 5, p. 1177 - 1180.
  • 3
  • [ 23902-69-4 ]
  • [ 3149-28-8 ]
  • [ 33332-30-8 ]
  • [ 40155-28-0 ]
References: [1] Journal of Chemical Research, Miniprint, 1984, # 10, p. 2860 - 2875.
  • 4
  • [ 32046-05-2 ]
  • [ 3149-28-8 ]
  • [ 33332-30-8 ]
  • [ 40155-28-0 ]
References: [1] Journal of Chemical Research, Miniprint, 1984, # 10, p. 2860 - 2875.
  • 5
  • [ 23902-69-4 ]
  • [ 3149-28-8 ]
  • [ 33332-31-9 ]
  • [ 33332-30-8 ]
  • [ 40155-28-0 ]
References: [1] Journal of Chemical Research, Miniprint, 1984, # 10, p. 2860 - 2875.
 

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Technical Information

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