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Chemical Structure| 333985-88-9 Chemical Structure| 333985-88-9

Structure of 333985-88-9

Chemical Structure| 333985-88-9

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Product Details of [ 333985-88-9 ]

CAS No. :333985-88-9
Formula : C15H22N2O2S
M.W : 294.41
SMILES Code : O=C(N1CCC(SC2=NC=CC=C2)CC1)OC(C)(C)C
MDL No. :MFCD07779471

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Application In Synthesis of [ 333985-88-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 333985-88-9 ]

[ 333985-88-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5029-67-4 ]
  • [ 134464-79-2 ]
  • [ 333985-88-9 ]
YieldReaction ConditionsOperation in experiment
106.2 mg With potassium carbonate; In N,N-dimethyl-formamide; at 70℃; for 16h; Preparation of tert-butyl 4-(pyridin-2-ylthio)piperidine-l-carboxylate. To a solution of tert-butyl 4-mercaptopiperidine-l-carboxylate (205 mg, 0.94 mmol) and 2- iodopyridine (263 mg, 1.28 mmol) in DMF (3.8 mL) was added potassium carbonate (521 mg, 3.8 mmol). The reaction mixture was stirred 16 h at 70C. The reaction was heated 16 h at 90C. After cooling to ambient temperature, the reaction mixture was diluted with EtOAc and washed with water and brine. The organic extracts were dried over anhydrous Na2S04(s), filtered and concentrated in vacuo. The residue was purified using silica chromatography (0- 50%) EtOAc in Hexanes as the gradient eluent) to afford the title compound (106.2 mg, 361 mmol) in sufficient purity for step 2. MS (apci) m/z = 295.2 (M+H).
 

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