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[ CAS No. 334-22-5 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 334-22-5
Chemical Structure| 334-22-5
Structure of 334-22-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 334-22-5 ]

CAS No. :334-22-5 MDL No. :MFCD00128968
Formula : C4H9Cl2N Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 142.03 Pubchem ID :-
Synonyms :

Safety of [ 334-22-5 ]

Signal Word:Danger Class:8
Precautionary Statements:P210-P260-P264-P270-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P332+P313-P362-P370+P378-P403+P235-P405-P501 UN#:1760
Hazard Statements:H302-H315-H314-H227 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 334-22-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 334-22-5 ]
  • Downstream synthetic route of [ 334-22-5 ]

[ 334-22-5 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 334-22-5 ]
  • [ 108-42-9 ]
  • [ 6640-24-0 ]
Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 39, p. 6875 - 6876
  • 2
  • [ 334-22-5 ]
  • [ 1009-85-4 ]
Reference: [1] Journal of Organic Chemistry, 1962, vol. 27, p. 2962
[2] Journal of the Chemical Society, 1948, p. 2175
  • 3
  • [ 334-22-5 ]
  • [ 1009-85-4 ]
Reference: [1] Chemistry and Industry (London, United Kingdom), 1961, p. 1017
  • 4
  • [ 109-12-6 ]
  • [ 334-22-5 ]
  • [ 20980-22-7 ]
Reference: [1] Research on Chemical Intermediates, 2011, vol. 37, # 8, p. 1041 - 1045
  • 5
  • [ 98-16-8 ]
  • [ 334-22-5 ]
  • [ 15532-75-9 ]
Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 39, p. 6875 - 6876
  • 6
  • [ 99-92-3 ]
  • [ 334-22-5 ]
  • [ 51639-48-6 ]
Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 39, p. 6875 - 6876
  • 7
  • [ 334-22-5 ]
  • [ 98-59-9 ]
  • [ 42137-88-2 ]
Reference: [1] Journal of the Chemical Society, <1959> 3616,3619,3622,
  • 8
  • [ 501-53-1 ]
  • [ 334-22-5 ]
  • [ 72791-76-5 ]
Reference: [1] Journal of Fluorine Chemistry, 2009, vol. 130, # 11, p. 1001 - 1010
[2] Patent: EP2009012, 2008, A1, . Location in patent: Page/Page column 30-31
[3] Patent: EP2208729, 2010, A1, . Location in patent: Page/Page column 55-57
  • 9
  • [ 24424-99-5 ]
  • [ 334-22-5 ]
  • [ 118753-70-1 ]
YieldReaction ConditionsOperation in experiment
49% With triethylamine In dichloromethane at 0 - 20℃; 3-(4-((2-(Pyrrolidin-1-yl)ethoxy)methyl)piperidin-4-yl)pyridine [amine A]Employed in the Synthesis to Give Example 49 (i): Bis-(2-chloroethylamine (16.34 g, 91.5 mmol) was dissolved in methylene chloride (150 ml) and triethylamine (40 ml, 293 mmol), the solution was cooled and Boc anhydride (20 ml, 218 mmol) was added dropwise at 0° C. The reaction mixture warmed up to room temperature and was stirred for 16 h. Hydrolysis was carried out with ice and the mixture was extracted with methylene chloride (500 ml). The organic phase was washed with water and saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) with 20percent ethyl acetate in hexane. Yield: 49percent
49% With triethylamine In dichloromethane at 0 - 20℃; Example 25; (S)-2-((1-(4-Methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-3-yl)-4-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanone (i): Bis-(2-chloroethyl)amine (16.34 g, 91.5 mmol) was dissolved in dichloromethane (150 ml) and triethylamine (40 ml, 293 mmol) and cooled; Boc anhydride (20 ml, 218 mmol) was added dropwise at 0° C. The reaction mixture warmed to room temperature and was stirred for 16 h. Hydrolysis with ice and extraction with dichloromethane (500 ml) were carried out. The organic phase was washed with water and saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) with 20percent ethyl acetate in hexane. Yield: 49percent
Reference: [1] Patent: US2009/264400, 2009, A1, . Location in patent: Page/Page column 92-93
[2] Patent: US2009/264407, 2009, A1, . Location in patent: Page/Page column 66
[3] Patent: US5661163, 1997, A,
[4] Patent: US6358959, 2002, B1, . Location in patent: Example 1
[5] Patent: WO2014/194242, 2014, A2, . Location in patent: Paragraph 00525-00526
  • 10
  • [ 24424-99-5 ]
  • [ 334-22-5 ]
  • [ 118753-70-1 ]
Reference: [1] Patent: US6319932, 2001, B1,
[2] Patent: US5977115, 1999, A,
[3] Patent: US6228870, 2001, B1,
  • 11
  • [ 334-22-5 ]
  • [ 118753-70-1 ]
Reference: [1] Patent: WO2006/136830, 2006, A1, . Location in patent: Page/Page column 182
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