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Chemical Structure| 334778-39-1 Chemical Structure| 334778-39-1

Structure of 334778-39-1

Chemical Structure| 334778-39-1

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Product Details of [ 334778-39-1 ]

CAS No. :334778-39-1
Formula : C9H8F2O3
M.W : 202.16
SMILES Code : OCCC1=CC=CC2=C1OC(F)(F)O2
MDL No. :MFCD09926447

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Application In Synthesis of [ 334778-39-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 334778-39-1 ]

[ 334778-39-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 75-21-8 ]
  • [ 1583-59-1 ]
  • [ 334778-39-1 ]
YieldReaction ConditionsOperation in experiment
38% 2,2-Difluoro-1,3-benzodioxole (0.56 mL, 5.0 mmol) was added to a solution of sec-butyllithium (in THF, 10 mL, 5.0 mmol) in cyclohexane at -78 C. The reaction mixture was treated with ethylene oxide (2.2 g, 50 mmol) and allowed to warm to 23 C. After 2 h, the reaction mixture was diluted with ether (100 mL), washed with water (5×25 mL) then brine (2×25 mL). The organic layer was dried (Na2SO4), concentrated in vacuo and the residue was purified by silica gel column chromatography (5-50% EtOAc in hexanes) to yield 2-(2,2-difluorobenzo[1,3]dioxol-4-yl)ethanol (286 mg, 38%).
  • 2
  • [ 1583-59-1 ]
  • [ 334778-39-1 ]
 

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