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Chemical Structure| 339016-67-0 Chemical Structure| 339016-67-0

Structure of 339016-67-0

Chemical Structure| 339016-67-0

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Product Details of [ 339016-67-0 ]

CAS No. :339016-67-0
Formula : C13H10N2O2
M.W : 226.24
SMILES Code : N#CC1=C(OC)C=CN=C1OC2=CC=CC=C2
MDL No. :MFCD00975465

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Application In Synthesis of [ 339016-67-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 339016-67-0 ]

[ 339016-67-0 ] Synthesis Path-Downstream   1~1

  • 1
  • diphenyl(trifluoromethanesulfonato)-λ3-iodane [ No CAS ]
  • [ 21642-98-8 ]
  • [ 339016-67-0 ]
  • 4-methoxy-2-oxo-1-phenyl-1,2-dihydropyridine-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
21%; 67% With caesium carbonate; In 1,2-dichloro-ethane; at 120℃; General procedure: A 25 mL Teflon-sealed flask was charged with the corresponding 2-pyridone 1 (0.5 mmol), diaryliodonium salt 2 (0.75 mmol, 1.5 equiv),and Cs2CO3 (0.75 mmol, 1.5 equiv) under an air atmosphere. DCE (5mL) was added to the flask. Then, the reaction vessel was sealed witha Teflon cap. The reaction mixture was stirred at 120 °C until the2-pyridone 1 was consumed completely (monitored by TLC). At thistime, the solvent was removed in vacuo and the residue was purifiedby flash column chromatography (the crude residue was dry loadedon silica gel, 1:20 to 1:1, EtOAc/PE) to provide the desired products 3and 4 (Scheme 2, Tables 2, 3).1-Phenylpyridin-2(1H)-one (3aa)19Yield: 0.054 g (63percent); orange solid; mp 94?95 °C.1H NMR (500 MHz, CDCl3): delta = 7.50?7.47 (m, 2 H), 7.43?7.36 (m, 4 H),7.34 (d, J = 8.5 Hz, 1 H), 6.66 (d, J = 10.5 Hz, 1 H), 6.25 (t, J = 7.0 Hz, 1 H).13C NMR (125 MHz, CDCl3): delta = 162.3, 140.9, 139.8, 137.9, 129.2,128.4, 126.4, 121.8, 105.8.
 

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