Alternatived Products of [ 343778-59-6 ]
Product Details of [ 343778-59-6 ]
CAS No. : | 343778-59-6 |
MDL No. : | |
Formula : |
C12H17ClN2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
224.73
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 343778-59-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 343778-59-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 343778-59-6 ]
- 1
-
[ 1722-12-9 ]
-
[ 343778-59-6 ]
-
[1-(3-Chloro-benzyl)-piperidin-4-yl]-pyrimidin-2-yl-amine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
42% |
With potassium carbonate In xylene for 24h; Heating; |
|
- 2
-
[ 68726-75-0 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
60% |
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether for 19h; Heating; |
|
|
Stage #1: 1-(m-chlorobenzyl)-4-piperidone oxime With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating / reflux;
Stage #2: With sodium hydroxide; water In tetrahydrofuran |
42.2.C.c
Scheme C, step c: 4-Amino-1-(3-chlorobenzyl)piperidine; 4-Amino-1-(3-chlorobenzyl)piperidine is prepared from 1-(3-chlorobenzyl)-4-piperidone oxime essentially as described above in Example 38, Scheme C, step c. |
- 3
-
[ 343778-59-6 ]
-
[ 211733-67-4 ]
-
[ 380425-89-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
In ethanol Heating; |
|
- 4
-
[ 380423-97-2 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
With bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile at 65℃; |
|
|
Stage #1: 4-carboxamide-1-(3-chlorobenzyl)piperidine With phenylmethylene bis(2,2,2-trifluoroacetate) In water; acetonitrile at 65℃;
Stage #2: With hydrogenchloride In water; acetonitrile at 0℃;
Stage #3: With sodium carbonate In water |
42.1.B.b
Scheme B, step b: 4-Amino-1-(3-chlorobenzyl)piperidine; 4-Amino-1-(3-chlorobenzyl)piperidine is prepared from 4-carboxamide-1-(3-chlorobenzyl)piperidine essentially as described above in Example 38, Scheme B, step b. |
- 5
-
[ 343778-59-6 ]
-
2-[trans-(4-aminocyclohexyl)amino]-6-[4-(1-(3-chlorobenzyl))piperidinylamino]-9-cyclopentylpurine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: ethanol / Heating
2: 24 h / 150 °C |
|
- 6
-
[ 620-20-2 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: Cs2CO3; KI / various solvent(s) / 5 h / 100 °C
2: PhI(CF3CO2)2 / acetonitrile; H2O / 65 °C |
|
- 7
-
[ 766-80-3 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
|
16.a a
a 4-Amino-1-(3-chlorobenzyl)-piperidine This compound was prepared using the procedure described in Example 8, Step C, using 3-chlorobenzylbromide in place of bromoethylbenzene. |
|
Multi-step reaction with 3 steps
1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 24 h / Reflux
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72.33 h / 0 - 20 °C / Inert atmosphere
3: hydrazine hydrate / methanol / 24 h / 20 °C |
|
|
Multi-step reaction with 2 steps
1: triethylamine / ethanol
2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C |
|
Reference:
[1]Current Patent Assignee: MERCK & CO INC - US5698573, 1997, A
[2]Jakubowska, Anna; Kulig, Katarzyna; Natalia, Guzior; Malawska, Barbara
[Acta poloniae pharmaceutica, 2012, vol. 69, # 3, p. 449 - 455]
[3]Cai, Pei; Fang, Si-Qiang; Yang, Xue-Lian; Wu, Jia-Jia; Liu, Qiao-Hong; Hong, Hao; Wang, Xiao-Bing; Kong, Ling-Yi
[ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2496 - 2511]
- 8
-
[ 1039021-95-8 ]
-
[ 343778-59-6 ]
-
[ 1033951-48-2 ]
Yield | Reaction Conditions | Operation in experiment |
|
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 100℃; |
|
Reference:
[1]Location in patent: scheme or table
Kertesz, Denis J.; Brotherton-Pleiss, Christine; Yang, Minmin; Wang, Zhanguo; Lin, Xianfeng; Qiu, Zongxing; Hirschfeld, Donald R.; Gleason, Shelley; Mirzadegan, Taraneh; Dunten, Pete W.; Harris, Seth F.; Villasenor, Armando G.; Hang, Julie Qi; Heilek, Gabrielle M.; Klumpp, Klaus
[Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 14, p. 4215 - 4218]
- 9
-
[ 5382-16-1 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 24 h / Reflux
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72.33 h / 0 - 20 °C / Inert atmosphere
3: hydrazine hydrate / methanol / 24 h / 20 °C |
|
- 10
-
2-[1-(3-chloro)benzylpiperidin-4-yl]isoindoline-1,3-dione
[ No CAS ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
With hydrazine hydrate In methanol at 20℃; for 24h; |
|
- 11
-
C13H9N3O3
[ No CAS ]
-
[ 343778-59-6 ]
-
1H-indole-5-carboxylic acid [1-(3-chloro)benzylpiperidin-4-yl]-amide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; |
|
- 12
-
1-(3-chloro)benzylpiperidin-4-ol
[ No CAS ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72.33 h / 0 - 20 °C / Inert atmosphere
2: hydrazine hydrate / methanol / 24 h / 20 °C |
|
- 13
-
[ 73874-95-0 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: triethylamine / ethanol
2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C |
|
|
Multi-step reaction with 2 steps
1.1: acetic acid / dichloromethane / 1 h / 20 °C
1.2: 16 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C |
|
Reference:
[1]Cai, Pei; Fang, Si-Qiang; Yang, Xue-Lian; Wu, Jia-Jia; Liu, Qiao-Hong; Hong, Hao; Wang, Xiao-Bing; Kong, Ling-Yi
[ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2496 - 2511]
[2]Hammill, Jared T.; Scott, Daniel C.; Min, Jaeki; Connelly, Michele C.; Holbrook, Gloria; Zhu, Fangyi; Matheny, Amy; Yang, Lei; Singh, Bhuvanesh; Schulman, Brenda A.; Guy, R. Kiplin
[Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2680 - 2693]
- 14
-
[ 1286272-71-6 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
With trifluoroacetic acid In dichloromethane at 20℃; for 4h; |
|
|
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 16h; |
|
Reference:
[1]Cai, Pei; Fang, Si-Qiang; Yang, Xue-Lian; Wu, Jia-Jia; Liu, Qiao-Hong; Hong, Hao; Wang, Xiao-Bing; Kong, Ling-Yi
[ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2496 - 2511]
[2]Hammill, Jared T.; Scott, Daniel C.; Min, Jaeki; Connelly, Michele C.; Holbrook, Gloria; Zhu, Fangyi; Matheny, Amy; Yang, Lei; Singh, Bhuvanesh; Schulman, Brenda A.; Guy, R. Kiplin
[Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2680 - 2693]
- 15
-
[ 343778-59-6 ]
-
[ 53188-07-1 ]
-
N-(1-(3-chlorobenzyl)piperidin-4-yl)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
36% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; |
|
Reference:
[1]Cai, Pei; Fang, Si-Qiang; Yang, Xue-Lian; Wu, Jia-Jia; Liu, Qiao-Hong; Hong, Hao; Wang, Xiao-Bing; Kong, Ling-Yi
[ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2496 - 2511]
- 16
-
[ 587-04-2 ]
-
[ 343778-59-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1.1: acetic acid / dichloromethane / 1 h / 20 °C
1.2: 16 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C |
|
Reference:
[1]Hammill, Jared T.; Scott, Daniel C.; Min, Jaeki; Connelly, Michele C.; Holbrook, Gloria; Zhu, Fangyi; Matheny, Amy; Yang, Lei; Singh, Bhuvanesh; Schulman, Brenda A.; Guy, R. Kiplin
[Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2680 - 2693]
- 17
-
[ 343778-59-6 ]
-
[ 329-01-1 ]
-
1-(1-(3-chlorobenzyl)piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; |
|
Reference:
[1]Hammill, Jared T.; Scott, Daniel C.; Min, Jaeki; Connelly, Michele C.; Holbrook, Gloria; Zhu, Fangyi; Matheny, Amy; Yang, Lei; Singh, Bhuvanesh; Schulman, Brenda A.; Guy, R. Kiplin
[Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2680 - 2693]