[ CAS No. 349-46-2 ] {[proInfo.proName]}

Name: 349-46-2|D-Cystine|98%
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Quality Control of [ 349-46-2 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 349-46-2 ]

Product Details of [ 349-46-2 ]

CAS No. :	349-46-2	MDL No. :	MFCD00002610
Formula :	C₆H₁₂N₂O₄S₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LEVWYRKDKASIDU-QWWZWVQMSA-N
M.W :	240.30	Pubchem ID :	6857538
Synonyms :

Calculated chemistry of [ 349-46-2 ]

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.67
Num. rotatable bonds :	7
Num. H-bond acceptors :	6.0
Num. H-bond donors :	4.0
Molar Refractivity :	55.1
TPSA :	177.24 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-11.37 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.38
Log Po/w (XLOGP3) :	-5.08
Log Po/w (WLOGP) :	-0.81
Log Po/w (MLOGP) :	-5.83
Log Po/w (SILICOS-IT) :	-1.33
Consensus Log Po/w :	-2.53

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	1.0
Egan :	1.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	2.33
Solubility :	51700.0 mg/ml ; 215.0 mol/l
Class :	Highly soluble
Log S (Ali) :	2.0
Solubility :	23900.0 mg/ml ; 99.6 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	0.95
Solubility :	2170.0 mg/ml ; 9.02 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	3.39

Safety of [ 349-46-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 349-46-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 349-46-2 ]

[ 349-46-2 ] Synthesis Path-Downstream 1~53

1
[ 50-99-7 ]
[ 923-32-0 ]
[ 349-46-2 ]

Yield	Reaction Conditions	Operation in experiment
	beim selektiven anaeroben Abbau durch Escherichia coli;

Reference： [1]Desnuelle [Enzymology, 1939, vol. 6, p. 388]

2
[ 56-89-3 ]
[ 349-46-2 ]

Reference： [1]Enzymology,1939,vol. 6,p. 388
[2]Journal of Biological Chemistry,1932,vol. 98,p. 581

3
[ 349-46-2 ]
[ 35554-98-4 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; bromine
	With bromine In water

Reference： [1]Cavallini et al. [Journal of Biological Chemistry, 1958, vol. 230, p. 25,27]
[2]Watkins,J.C. [Journal of medicinal and pharmaceutical chemistry, 1962, vol. 5, p. 1187 - 1199]

4
[ 349-46-2 ]
[ 939-69-5 ]
[ 2591-17-5 ]

Reference： [1]Journal of the American Chemical Society,1963,vol. 85,p. 337 - 343

5
[ 67-56-1 ]
[ 112-16-3 ]
[ 349-46-2 ]
D-(-)-dilauroylcystine dimethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride 1.) 12 h; Multistep reaction;

Reference： [1]Heath, Jonathan G.; Arnett, Edward M. [Journal of the American Chemical Society, 1992, vol. 114, # 12, p. 4500 - 4514]

6
[ 67-56-1 ]
[ 349-46-2 ]
l-cystine dimethyl ester dihydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With thionyl chloride at 0 - 20℃;	19 Example 19 meso-C ystine dimethyl ester dihydrochloride (LH1728) D-Cystine-OH (500 mg, 2.1 mmol) was dissolved in 10 mL of methanol and cooled to 0 °C. Thionyl chloride (1 mL, 12.5 mmol) was added slowly to the solution then the reaction mixture was brought to room temperature and left to stir for overnight. The solvent was evaporated under reduced pressure then redissolved in chloroform and evaporated again under reduced pressure which was repeated twice to help getting rid of thionyl chloride. The white foamy residue was then dried on pump for overnight to give D-Cystine dimethyl ester dihydrochloride as a white solid (701 mg, 98%). 1H NMR (400 MHz, D2O) d 3.34-3.45 (m, 4H), 3.88 (s, 6H), 4.61 (b, 2H). 13C NMR (100 MHz, D2O) δ 169.13, 53.97, 51.56, 35.70.
79%	With thionyl chloride at 20 - 70℃; for 5h;
	With thionyl chloride Heating;

Reference： [1]Current Patent Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - WO2021/119475, 2021, A1 Location in patent: Paragraph 0024; 0171-0172
[2]Ten Cate, A. Tessa; Dankers, Patricia Y. W.; Kooijman, Huub; Spek, Anthony L.; Sijbesma, Rint P.; Meijer [Journal of the American Chemical Society, 2003, vol. 125, # 23, p. 6860 - 6861]
[3]Yu, Lin; Dennis, Edward A. [Journal of the American Chemical Society, 1992, vol. 114, # 23, p. 8757 - 8762]

7
[ 4227-95-6 ]
[ 349-46-2 ]
[ 132090-48-3 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonia; sodium 1.) 20 min, 2.) 45 min; Yield given. Multistep reaction;

Reference： [1]Parry; Li; Gomez [Journal of the American Chemical Society, 1992, vol. 114, # 15, p. 5946 - 5959]

8
[ 629-04-9 ]
[ 349-46-2 ]
[ 121961-53-3 ]

Yield	Reaction Conditions	Operation in experiment
93%	With ammonia; sodium

Reference： [1]Van den Broek; Lazaro; Zylicz; Fennis; Missler; Lelieveld; Garzotto; Wagener; Ballesta; Ottenheijm [Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 2002 - 2015]

9
[ 540-88-5 ]
[ 349-46-2 ]
(2S,2'S)-di-tert-butyl 3,3'-disulfanediylbis(2-aminopropanoate) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With 60percent HClO₄ at 20℃; for 48h;
72%	Stage #1: acetic acid tert-butyl ester; S,S-cystine With perchloric acid In water at 20℃; for 48h; Stage #2: With sodium hydroxide In water Cooling with ice;	6 D-cystine (5.20 mmol) was dissolved in a 60% aqueous perchloric acid solution (2.1 mL), then, t-butyl acetate (12.6 mL) was dropwise added to the resulting solution, the mixture (reaction liquid) was stirred at room temperature for two days, the reaction liquid was ice-cooled and the pH value of the liquid was adjusted to a level of about 11 using a 4N aqueous sodium hydroxide solution. The temperature of the reaction liquid was brought back to room temperature, the reaction liquid was extracted 6 times with ethyl acetate (50 mL) and the resulting organic phases were combined together, followed by the drying of the combined organic phase over sodium sulfate and the subsequent concentration of the organic phase to thus give Compound 9 as an oily product.Yield: 72%. ESI MS m/z 353.2 (M+H)+ 1H NMR (400 MHz, CDCl3) δ: 1.48; (18H, s), 2.88; (2H, dd, J=8.0, 13.2 Hz), 3.14; (2H, dd, J=4.4, 13.2 Hz), 3.69; (2H, dd, J=4.4, 8.0 Hz)
	With perchloric acid at 25℃; for 48h;

In perchloric acid at 20℃; for 24h;

Reference： [1]Marcantoni, Enrico; Massaccesi, Massimo; Petrini, Marino; Bartoli, Giuseppe; Bellucci, Maria Cristina; Bosco, Marcella; Sambri, Letizia [Journal of Organic Chemistry, 2000, vol. 65, # 15, p. 4553 - 4559]
[2]Current Patent Assignee: AJINOMOTO COMPANY INC - US2012/282386, 2012, A1 Location in patent: Page/Page column 9
[3]Meyers; Amos [Journal of the American Chemical Society, 1980, vol. 102, # 2, p. 870 - 872]
[4]Woon, Esther C. Y.; Tumber, Anthony; Kawamura, Akane; Hillringhaus, Lars; Ge, Wei; Rose, Nathan R.; Ma, Jerome H. Y.; Chan, Mun Chiang; Walport, Louise J.; Che, Ka Hing; Ng, Stanley S.; Marsden, Brian D.; Oppermann, Udo; McDonough, Michael A.; Schofield, Christopher J. [Angewandte Chemie - International Edition, 2012, vol. 51, # 7, p. 1631 - 1634]

10
[ 349-46-2 ]
[ 111-25-1 ]
[ 121961-52-2 ]

Yield	Reaction Conditions	Operation in experiment
98%	With ammonia; sodium

Reference： [1]Van den Broek; Lazaro; Zylicz; Fennis; Missler; Lelieveld; Garzotto; Wagener; Ballesta; Ottenheijm [Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 2002 - 2015]

11
[ 349-46-2 ]
[ 20710-47-8 ]
(methyl-⁽¹³⁾C,⁽²⁾H₃)-S-methyl-D-cysteine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With ammonia; sodium 1.) 20 min, 2.) 45 min; Yield given. Multistep reaction;

Reference： [1]Parry; Li; Gomez [Journal of the American Chemical Society, 1992, vol. 114, # 15, p. 5946 - 5959]

12
(D)-2-Amino-3-(benzylthio)propanoic acid [ No CAS ]
[ 349-46-2 ]

Yield	Reaction Conditions	Operation in experiment
75%	With ammonia; sodium 1) -78 deg C, 1.5 h; 2) room temperature, overnight;

Reference： [1]Axelsson, B. Svante; O'Toole, Kevin J.; Spencer, Philip A.; Young, Douglas W. [Journal of the Chemical Society. Perkin transactions I, 1994, # 7, p. 807 - 816]

13
[ 87219-42-9 ]
[ 349-46-2 ]

Yield	Reaction Conditions	Operation in experiment
75.3%	With hydrogen bromide for 12h; Ambient temperature;

Reference： [1]Nakajima; Okawa [Bulletin of the Chemical Society of Japan, 1983, vol. 56, # 5, p. 1565 - 1566]

14
[ 349-46-2 ]
[ 501-53-1 ]
(2S)-2-[(benzyloxy)carbonyl]amino}-3-[(2S)-2-[(benzyloxy)carbonyl]amino}-2-carboxyethyl]disulfanyl}propanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%
	With sodium hydroxide In tetrahydrofuran; water at 25℃; for 1h;
	With sodium hydroxide In tetrahydrofuran; water at 25℃; for 1h;

Reference： [1]Bounaga, Sakina; Galleni, Moreno; Laws, Andrew P; Page, Michael I [Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 2, p. 503 - 510]
[2]Boger; Ichikawa; Tse; Hedrick; Jin [Journal of the American Chemical Society, 2001, vol. 123, # 4, p. 561 - 568]
[3]Boger, Dale L.; Ichikawa, Satoshi [Journal of the American Chemical Society, 2000, vol. 122, # 12, p. 2956 - 2957]

15
[ 349-46-2 ]
[ 556050-48-7 ]
(S)-3-{(S)-2-Carboxy-2-[4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-octyl)-benzyloxycarbonylamino]-ethyldisulfanyl}-2-[4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-octyl)-benzyloxycarbonylamino]-propionic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With triethylamine In tetrahydrofuran; water at 25℃;

Reference： [1]Curran, Dennis P.; Amatore, Muriel; Guthrie, David; Campbell, Matthew; Go, Eisan; Luo, Zhiyong [Journal of Organic Chemistry, 2003, vol. 68, # 12, p. 4643 - 4647]

16
[ 349-46-2 ]
[ 28920-43-6 ]
3-[2-carboxy-2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-ethyldisulfanyl]-2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-propionic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide In tetrahydrofuran at 25℃; for 1h;

Reference： [1]Boger; Ichikawa; Tse; Hedrick; Jin [Journal of the American Chemical Society, 2001, vol. 123, # 4, p. 561 - 568]

17
[ 349-46-2 ]
N^ω,N^ω'-[{(S,S)-1,6-bis(methoxycarbonyl)-3,4-dithia}-hexylene]-bis-(2-ureido-6-tridecyl-4-pyrimidinone) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: 79 percent / SOCl₂ / 5 h / 20 - 70 °C 2.1: Et₃N / CHCl₃ 2.2: 70 percent / CHCl₃ / 50 °C

Reference： [1]Ten Cate, A. Tessa; Dankers, Patricia Y. W.; Kooijman, Huub; Spek, Anthony L.; Sijbesma, Rint P.; Meijer [Journal of the American Chemical Society, 2003, vol. 125, # 23, p. 6860 - 6861]

18
[ 349-46-2 ]
(D-Cys-OTce)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: aq. NaOH / tetrahydrofuran / 1 h / 25 °C 2: 1.25 g / dicyclohexylcarbodiimide; HOBt / pyridine / 24 h / -20 °C 3: Et₂NH / acetonitrile / 1 h / 25 °C

Reference： [1]Boger; Ichikawa; Tse; Hedrick; Jin [Journal of the American Chemical Society, 2001, vol. 123, # 4, p. 561 - 568]

19
[ 349-46-2 ]
[ 328553-43-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: aq. NaOH / tetrahydrofuran / 1 h / 25 °C 2.1: 1.25 g / dicyclohexylcarbodiimide; HOBt / pyridine / 24 h / -20 °C 3.1: Et₂NH / acetonitrile / 1 h / 25 °C 4.1: DMAP; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.5 h / 25 °C 4.2: 53 percent / CH₂Cl₂ / 24 h / 25 °C

Reference： [1]Boger; Ichikawa; Tse; Hedrick; Jin [Journal of the American Chemical Society, 2001, vol. 123, # 4, p. 561 - 568]

20
[ 349-46-2 ]
[ 328553-42-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: aq. NaOH / tetrahydrofuran / 1 h / 25 °C 2: 1.25 g / dicyclohexylcarbodiimide; HOBt / pyridine / 24 h / -20 °C

Reference： [1]Boger; Ichikawa; Tse; Hedrick; Jin [Journal of the American Chemical Society, 2001, vol. 123, # 4, p. 561 - 568]

21
[ 349-46-2 ]
[ 270587-83-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: NaOH / tetrahydrofuran; H₂O / 1 h / 25 °C 2: pyridine; HOBt; DCC / 24 h / -20 °C
	Multi-step reaction with 2 steps 1: NaOH / tetrahydrofuran; H₂O / 1 h / 25 °C 2: 76 percent / DCC; HOBt / pyridine / 24 h / -20 °C

Reference： [1]Boger; Ichikawa; Tse; Hedrick; Jin [Journal of the American Chemical Society, 2001, vol. 123, # 4, p. 561 - 568]
[2]Boger, Dale L.; Ichikawa, Satoshi [Journal of the American Chemical Society, 2000, vol. 122, # 12, p. 2956 - 2957]

22
[ 349-46-2 ]
(Z-D-Cys-D-penicillamineOMe)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 90 percent / dicyclohexylcarbodiimide; Et₃N / CH₂Cl₂ / 0 - 20 °C

Reference： [1]Bounaga, Sakina; Galleni, Moreno; Laws, Andrew P; Page, Michael I [Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 2, p. 503 - 510]

23
[ 349-46-2 ]
(Z-D-Cys-D-penicillamineOH)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 90 percent / dicyclohexylcarbodiimide; Et₃N / CH₂Cl₂ / 0 - 20 °C 2: 70 percent / aq. LiOH / methanol / 18 h / 5 °C

Reference： [1]Bounaga, Sakina; Galleni, Moreno; Laws, Andrew P; Page, Michael I [Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 2, p. 503 - 510]

24
[ 349-46-2 ]
[ 339175-32-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 90 percent / dicyclohexylcarbodiimide; Et₃N / CH₂Cl₂ / 0 - 20 °C 2: 70 percent / aq. LiOH / methanol / 18 h / 5 °C

Reference： [1]Bounaga, Sakina; Galleni, Moreno; Laws, Andrew P; Page, Michael I [Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 2, p. 503 - 510]

25
[ 349-46-2 ]
N,N'-ditrityl-D-cystine dimethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: thionyl chloride / Heating 2: 13.5 g / triethylamine / CHCl₃ / 24 h / Ambient temperature

Reference： [1]Yu, Lin; Dennis, Edward A. [Journal of the American Chemical Society, 1992, vol. 114, # 23, p. 8757 - 8762]

26
[ 349-46-2 ]
[ 2550-36-9 ]
[ 369360-52-1 ]

Yield	Reaction Conditions	Operation in experiment
		200.A (2S)-2-((tert-butoxycarbonyl)amino)-3-(cyclohexylmethylsulfanyl)propanoic acid EXAMPLE 200A (2S)-2-((tert-butoxycarbonyl)amino)-3-(cyclohexylmethylsulfanyl)propanoic acid The desired product was prepared by substituting cyclohexylmethyl bromide for 2-brompropane and D-cystine for D-homocystine in Example 123A.

Reference： [1]Current Patent Assignee: ABBVIE INC - US2002/2152, 2002, A1

27
[ 349-46-2 ]
[ 824-94-2 ]
H-D-Cys(MBzl)-OH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium chloride In ammonia; water	18.a (a) (a) H-D-Cys(MBzl)-OH 15 g of D-cystine are dissolved in approximately 1.5 liters of dry ammonia, and sodium metal is added while stirring and boiling until the solution is blue coloured. Decolouration is effected with a small amount of ammonium chloride, and 30 g of p-methoxybenzyl chloride are added dropwise while stirring and boiling. The reaction mixture is evaporated to dryness, the residue is dissolved in water and extraction is effected with ethyl acetate. The pH of the aqueous phase is adjusted to the isoelectric point (pH 5-6) with hydrochloric acid. Filtration, washing with water and drying are effected, whereby H-D-Cys(MBzl)-OH is obtained. M.P. 204° (decomp.); [α]D20 = -24° in 1N sodium hydroxide.

Reference： [1]Current Patent Assignee: Sandoz (in: Novartis); NOVARTIS AG - US4120852, 1978, A

28
[ 349-46-2 ]
[ 98-88-4 ]
N,N'-bis(benzoyl)-D-cystine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With sodium hydroxide In diethyl ether; ethanol; water at 0 - 20℃;
	With sodium hydroxide at 0 - 20℃;

Reference： [1]Xue, Yu; Fehn, Natalie; Brandt, Viktoria Katharina; Stasi, Michele; Boekhoven, Job; Heiz, Ueli; Kartouzian, Aras [Chirality, 2022, vol. 34, # 3, p. 550 - 558]
[2]Liénard, Benoît M. R.; Hüting, Rebekka; Lassaux, Patricia; Galleni, Moreno; Frère, Jean-Marie; Schofield, Christopher J. [Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 684 - 688]

29
[ 349-46-2 ]
[ 103-80-0 ]
[ 1009810-11-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide at 0 - 20℃;

Reference： [1]Liénard, Benoît M. R.; Hüting, Rebekka; Lassaux, Patricia; Galleni, Moreno; Frère, Jean-Marie; Schofield, Christopher J. [Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 684 - 688]

30
[ 349-46-2 ]
[ 645-45-4 ]
[ 1009810-12-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide at 0 - 20℃;

31
[ 349-46-2 ]
[ 1710-98-1 ]
[ 1009810-14-3 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide at 0 - 20℃;

32
[ 52-90-4 ]
[ 349-46-2 ]

Yield	Reaction Conditions	Operation in experiment
	With dihydrogen peroxide at 20℃; Microbiological reaction;
	With sodium nitrate; 8,13-bis(vinyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid tin(IV) dichloride; 5′-d(TTTGGGTAGGGCGGGTTGGG)-3′ In aq. phosphate buffer at 20℃; for 0.5h;

Reference： [1]Location in patent: scheme or table Ohtsu, Iwao; Wiriyathanawudhiwong, Natthawut; Morigasaki, Susumu; Nakatani, Takeshi; Kadokura, Hiroshi; Takagi, Hiroshi [Journal of Biological Chemistry, 2010, vol. 285, # 23, p. 17479 - 17487]
[2]Garai-Ibabe, Gaizka; Möller, Marco; Saa, Laura; Grinyte, Ruta; Pavlov, Valeri [Analytical Chemistry, 2014, vol. 86, # 20, p. 10059 - 10064]

33
[ 349-46-2 ]
[ 1333342-52-1 ]

Yield	Reaction Conditions	Operation in experiment
34%	With hydrogenchloride; bromine In water at 65℃; for 0.666667h;

Reference： [1]Location in patent: experimental part Sasahara, Ayako; Nanatani, Kei; Enomoto, Masaru; Kuwahara, Shigefumi; Abe, Keietsu [Journal of Biological Chemistry, 2011, vol. 286, # 33, p. 29044 - 29052]

34
[ 77826-60-9 ]
[ 349-46-2 ]

Yield	Reaction Conditions	Operation in experiment
85%	With triethylsilane; trifluoroacetic acid at 25℃; for 48h;

Reference： [1]Li, Zhengkai; Ke, Fang; Deng, Hang; Xu, Hualong; Xiang, Haifeng; Zhou, Xiangge [Organic and Biomolecular Chemistry, 2013, vol. 11, # 18, p. 2943 - 2946]

35
type I collagen from Bester sturgeon scales [ No CAS ]
[ 56-41-7 ]
[ 72-18-4 ]
[ 56-45-1 ]
[ 72-19-5 ]
[ 61-90-5 ]
[ 73-32-5 ]
[ 63-68-3 ]
[ 56-87-1 ]
[ 56-84-8 ]
(5R)-5-hydroxy-L-lysine [ No CAS ]
[ 74-79-3 ]
[ 349-46-2 ]
[ 63-91-2 ]
[ 60-18-4 ]
[ 56-40-6 ]
[ 147-85-3 ]
[ 51-35-4 ]
[ 71-00-1 ]