34967-61-8|2-(2,5-Dichlorothiophen-3-yl)acetic acid| Ambeed

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CAS No. :	34967-61-8
Formula :	C₆H₄Cl₂O₂S
M.W :	211.07
SMILES Code :	O=C(O)CC1=C(Cl)SC(Cl)=C1

Yield	Reaction Conditions	Operation in experiment
72%	With N-chloro-succinimide; In acetic acid; at 20℃; for 12h;	A solution of 3-thiophene acetic acid (1.42 g, 10.0 mmol) in acetic acid (10 mL) was treated with N-chlorosuccinimide (3. 1 g, 23 mmol, 2.3 equivalents), and the solution was stirred for 12 h at room temperature then concentrated in vacuo. The residue was diluted with water and stirred for 1 h whereupon the resulting solid was collected by filtration. The solid was dried in a vacuum oven at room temperature for 10 hours providing 1.51 g (72%) of (2, 5-dichlorothien-3-vl) acetic acid as a brown solid, which was used as such in the next step. MS (ESI) m/z 209/211/213 ( [M-H]-).
72%	With N-chloro-succinimide; In acetic acid; at 20℃; for 12h;	A solution of 3-thiophene acetic acid (1.42 g, 10.0 mmol} in acetic acid (10 mL) was treated with N-chlorosuccinimide (3. 1g, 23 mmol, 2.3 equivalents), and the solution was stirred for 12 h at room temperature then concentrated in vacuo. The residue was diluted with water and stirred for 1 h whereupon the resulting solid was collected by filtration. The solid was dried in a vacuum oven at room temperature for 10 hours providing 1.51 g (72%) of (2. 5-dichlorothien-3-yl) acetic acid as a brown solid, which was used as such in the next step. MS (ESI) m/z 209/211/213 ( [M-H]-).
72%	With N-chloro-succinimide; In acetic acid; at 20℃; for 12h;	Step 1: A solution of 3-thiophene acetic acid (1.42 g, 10.0 mmol) in acetic acid (10 mL) was treated with N-chlorosuccinimide (3. 1g, 23 mmol, 2.3 equivalents), and the solution was stirred for 12 h at room temperature then concentrated in vacuo. The residue was diluted with water and stirred for 1 h whereupon the resulting solid was collected by filtration. The solid was dried in a vacuum oven at room temperature for 10 hours providing 1.51 g (72%) of (2, 5-dichlorothien-3-yl) acetic acid as a brown solid, which was used as such in the next step. MS (ESI) m/z 209/211/213 ( [M-H]-).

72%	With N-chloro-succinimide; In acetic acid; at 20℃; for 12h;	Example 141: 1-(2, 5-dichlorothien-3-vl)-2-piperazine-1-ylethyllcyclohexanol dihvdrochloride [0391] Step 1: A solution of 3-thiophene acetic acid (1.42 g, 10.0 mmol) in acetic acid (10 mL) was treated with N-chlorosuccinimide (3. 1g, 23 mmol, 2.3 equivalents), and the solution was stirred for 12 h at room temperature then concentrated in vacuo. The residue was diluted with water and stirred for 1 h whereupon the resulting solid was collected by filtration. The solid was dried in a vacuum oven at room temperature for 10 hours providing 1.51 g (72%) of (2. 5-dichlorothien-3-yl) acetic acid as a brown solid, which was used as such in the next step. MS (ESI) m/z 209/211/213 ( [M-H]-).
72%	With N-chloro-succinimide; In acetic acid; at 20℃; for 12h;	A solution of 3-thiophene acetic acid (1.42 g, 10.0 mmol) in acetic acid (10 mL) was treated with N-chlorosuccinimide (3. 1g, 23 mmol, 2.3 equivalents), and the solution was stirred for 12 h at room temperature then concentrated in vacuo. The residue was diluted with water and stirred for 1 h whereupon the resulting solid was collected by filtration. The solid was dried in a vacuum oven at room temperature for 10 hours providing 1.51 g (72%) of (2. 5-dichlorothien-3-yl) acetic acid as a brown solid, which was used as such in the next step. MS (ESI) m/z 209/211/213 ( [M-H]-).

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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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CAS No.: 34967-61-8

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CAS No.: 34967-61-8

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[ 34967-61-8 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed