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Chemical Structure| 351-33-7 Chemical Structure| 351-33-7

Structure of 351-33-7

Chemical Structure| 351-33-7

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Product Details of [ 351-33-7 ]

CAS No. :351-33-7
Formula : C9H6Cl2F3NO
M.W : 272.05
SMILES Code : O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)CCl
MDL No. :MFCD00467443

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Application In Synthesis of [ 351-33-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 351-33-7 ]

[ 351-33-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 102877-78-1 ]
  • [ 351-33-7 ]
  • N-(4-chloro-3-trifluoromethylphenyl)-2-[4-(4-pyridinyloxy)phenylamino]acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
5% With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 100℃; for 6h; A solution of 146.1 mg (0.54 [MMOL)] of compound 9 in dimethylformamide (DMF) is given to a solution of 100 mg (0.54 [MMOL)] of compound 2 and 0.1 mi (0.59 [MMOL)] N-Ethyl-diisopropylamine in DMF. The reaction mixture is heated to 100 [C] for 6 h, then evaporated and the residue is purified by preparative HPLC to yield 10.7 mg (5 %) colourless solid.
  • 2
  • [ 351-33-7 ]
  • [ 100570-24-9 ]
  • [ 875656-36-3 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In toluene; at 90.0℃; for 3.0h; Step 2. N-(4-chloro-3-trifluoromethylphenyl)-2-[(R)-l-(3,4-dimethoxyphenyl)-ethylamino]-acetamideA mixture of (R)-l-(3,4-dimethoxyphenyl)-ethylamine (1.5 g, 8.1 mmol, obtained by resolution of the racemic amine with (R)-mandelic acid), 2-chloro-N-(4-chloro-3-trifluoromethylphenyl)-acetamide (2.1g, 7.7 mmol) and triethylamine (3.4 mL, 24 mmol) in toluene (30 mL) is heated at 90C (oil bath temperature) for 3 h. After cooling to room temperature the mixture is poured into water (200 mL) and partitioned into 100 mL of ethyl acetate. The organic layer is dried with MgSO4 and filtered and the solvent removed under reduced pressure. Flash chromatography on silicagel eluting with 5% methanol in ethyl acetate furnishes the title compound as a dry foam. LC/MS: 417 (M+l).
 

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