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[ CAS No. 35578-28-0 ]

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2D
Chemical Structure| 35578-28-0
Chemical Structure| 35578-28-0
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Product Details of [ 35578-28-0 ]

CAS No. :35578-28-0MDL No. :MFCD12107254
Formula : C3H8ClNO2S Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :157.62Pubchem ID :-
Synonyms :

Computed Properties of [ 35578-28-0 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 35578-28-0 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P280-P305+P351+P338UN#:N/A
Hazard Statements:H302Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 35578-28-0 ]

  • Upstream synthesis route of [ 35578-28-0 ]
  • Downstream synthetic route of [ 35578-28-0 ]

[ 35578-28-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 35578-28-0 ]
  • [ 5908-62-3 ]
YieldReaction ConditionsOperation in experiment
100% With sodium ethanolate In ethanol at 20℃; for 5 h; Heating / reflux To a solution of 3-CHLORO-1-PROPANESULFONAMIDE (D21A) (27 g, 170 mmol, 1 equiv) in EtOH (250 mi) at room temperature was added NaOEt (11.7 g, 170 MMOL, 1 equiv). The resulting mixture was refluxed for 5 h then cooled to room temperature and concentrated in vacuo. The residual solid was extracted thoroughly with CH2CI2 and the extracts were concentrated in vacuo to give isothiazolidine 1,1-dioxide (D22a) (20 g, 100percent).
Reference: [1] Patent: WO2004/50619, 2004, A1, . Location in patent: Page 24
[2] Journal of the American Chemical Society, 2015, vol. 137, # 17, p. 5638 - 5641
[3] Journal of Organic Chemistry, 1987, vol. 52, # 11, p. 2162 - 2166
[4] Patent: WO2012/3283, 2012, A1, . Location in patent: Page/Page column 206-207
[5] Patent: US2012/316147, 2012, A1, . Location in patent: Page/Page column 62-63
[6] Patent: WO2012/168350, 2012, A1, . Location in patent: Page/Page column 133; 134
[7] DRP/DRBP Org.Chem.,
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[ 35578-28-0 ]

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