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Chemical Structure| 35578-28-0 Chemical Structure| 35578-28-0

Structure of 35578-28-0

Chemical Structure| 35578-28-0

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Product Details of [ 35578-28-0 ]

CAS No. :35578-28-0
Formula : C3H8ClNO2S
M.W : 157.62
SMILES Code : O=S(CCCCl)(N)=O
MDL No. :MFCD12107254
Boiling Point : No data available
InChI Key :QMSSNRWVQWLVHG-UHFFFAOYSA-N
Pubchem ID :13614818

Safety of [ 35578-28-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 35578-28-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35578-28-0 ]

[ 35578-28-0 ] Synthesis Path-Downstream   1~1

  • 1
  • sodium methoxide-methanol [ No CAS ]
  • [ 112581-77-8 ]
  • 2N-potassium hydrogensulfide [ No CAS ]
  • [ 35578-28-0 ]
  • 2-chloro-6-[(3-sulfamoylpropyl)thio]imidazo[1,2-b]pyridazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; water; EXAMPLE 44 Production of 2-chloro-6-[(3-sulfamoylpropyl)thio]imidazo[1,2-b]pyridazine To a solution of 1.57 g of 3-chloro-1-propanesulfonamide in 20 ml of methanol was added 20 ml of 2N-potassium hydrogensulfide, followed by heating at 70 C. for 50 minutes. Further, 1.48 g of 28% sodium methoxide-methanol solution and 1.32 g of <strong>[112581-77-8]2,6-dichloroimidazo[1,2-b]pyridazine</strong> [Japanese Unexamined Patent Publication No. SHO 64(1989)-38092] were added to the reaction mixture, and refluxed at 100 C. for 3 hours. The mixture was concentrated under reduced pressure. Then, the residue to which was 20 ml of water was added was adjusted to pH 7.0 with 1N-hydrochloric acid. The precipitated crystals were collected by filtration and subjected to a silica gel column chromatography, eluding with chloroform and methanol (50:1). The corresponding combined fractions were concentrated, and the residue was recrystallized to obtain 1.1 g of the title compound. mp: 117-118 C. Elementary analysis: C9 H11 N4 O2 S2 Cl: Calculated (%): C, 35.23; H, 3.61; Nm 18.26. Found (%): C, 35.39; H, 3.71; N, 18.25.
 

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