[ CAS No. 35856-62-3 ] {[proInfo.proName]}

Name: 35856-62-3|Piperidine-1-sulfonyl chloride|95%
Brand: Ambeed
SKU: A637744
Rating: 92 (32 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

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3d Animation Molecule Structure of 35856-62-3

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Quality Control of [ 35856-62-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 35856-62-3 ]

SDS Specification

Alternatived Products of [ 35856-62-3 ]

Product Details of [ 35856-62-3 ]

CAS No. :	35856-62-3	MDL No. :	MFCD03250329
Formula :	C₅H₁₀ClNO₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QQJYAXDCMMXECR-UHFFFAOYSA-N
M.W :	183.66	Pubchem ID :	11298344
Synonyms :

Calculated chemistry of [ 35856-62-3 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	44.61
TPSA :	45.76 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.61 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.94
Log Po/w (XLOGP3) :	1.14
Log Po/w (WLOGP) :	1.66
Log Po/w (MLOGP) :	0.7
Log Po/w (SILICOS-IT) :	0.46
Consensus Log Po/w :	1.18

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.63
Solubility :	4.3 mg/ml ; 0.0234 mol/l
Class :	Very soluble
Log S (Ali) :	-1.7
Solubility :	3.71 mg/ml ; 0.0202 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.15
Solubility :	13.1 mg/ml ; 0.0714 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.0

Safety of [ 35856-62-3 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310	UN#:	3265
Hazard Statements:	H314	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 35856-62-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 35856-62-3 ]
Downstream synthetic route of [ 35856-62-3 ]

[ 35856-62-3 ] Synthesis Path-Upstream 1~6

1
[ 110-89-4 ]
[ 35856-62-3 ]

Yield	Reaction Conditions	Operation in experiment
70%	With sulfuryl dichloride; triethylamine In dichloromethane at 0 - 20℃; for 2 h;	Example 1: Piperidine-l-sulfonyl chloride To a solution of sulfurylchloride (238 g, 1.76 moles) in dichloromethane (500 ml), a mixture of piperidine (100 g, 1.17 moles) and triethylamine (178 g, 1.76 moles) in dichloromethane (500 ml) was added at 0 °C - 5 °C. The reaction mass was warmed to room temperature, stirred for 2 hours, and quenched in ice cold water. After washing with water (2 x 5 volumes), the organic layer was separated organic layer. The reaction mass was dried over sodium sulfate and solvent evaporated off to obtain oily residue (151.3g, 70percent yield). The ^{FontWeight="Bold" FontSize="10"}H NMR spectra of the resulting solid was obtained to reveal the following spectral peaks: ^{FontWeight="Bold" FontSize="10"}H NMR (300 MHz, CDC1₃) δ =1.58-1.62(m, 2H), 1.69- 1.83(m, 4H), 3.31-3.42(m, 4H)
46%	With sulfuryl dichloride In diethyl ether at -78 - 20℃; for 3 h;	To 0.95mL (11. 7mmol) of sulfuryl chloride in 20 mL ether was added dropwise 2.3mL (23. 4mmol) of piperidine at-78° C. The reaction was stirred at rt for 3hrs. The insoluble solid was removed by filtration and the filtrate was washed with 1 N HCI, sat NaHCO3 and brine. The organic layer was dried over MgS04, filtered and the filtrate was concentrated to dryness to give 1. 00g of 10004b. yield 46percent

Reference： [1] Patent: WO2015/83066, 2015, A1, . Location in patent: Page/Page column 11-12
[2] Journal of Fluorine Chemistry, 1982, vol. 20, p. 425 - 438
[3] Patent: WO2005/87721, 2005, A2, . Location in patent: Page/Page column 81-82
[4] Archiv der Pharmazie (Weinheim, Germany), 1958, vol. 291, p. 7,11
[5] Bulletin de la Societe Chimique de France, 1936, vol. <5> 3, p. 2143,2146, 2149, 2150
[6] Archiv der Pharmazie (Weinheim, Germany), 1958, vol. 291, p. 7,11
[7] Bulletin de la Societe Chimique de France, 1936, vol. <5> 3, p. 2143,2146, 2149, 2150
[8] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 3, p. 499 - 502
[9] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3367 - 3370
[10] Patent: WO2009/151152, 2009, A1, . Location in patent: Page/Page column 89

2
[ 110-89-4 ]
[ 35856-62-3 ]
[ 6091-44-7 ]

Reference： [1] Journal of the American Chemical Society, 2013, vol. 135, # 29, p. 10638 - 10641

3
[ 6091-44-7 ]
[ 35856-62-3 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 24, p. 3075 - 3080

4
[ 110-85-0 ]
[ 35856-62-3 ]

Reference： [1] Patent: US6372778, 2002, B1, . Location in patent: Example 150

5
[ 2156-71-0 ]
[ 35856-62-3 ]

Reference： [1] Justus Liebigs Annalen der Chemie, 1959, vol. 624, p. 25,29

6
[ 110-89-4 ]
[ 16475-29-9 ]
[ 35856-62-3 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1936, vol. <5> 3, p. 2143,2146, 2149, 2150

[ 35856-62-3 ] Synthesis Path-Downstream 1~88

1
[ 110-89-4 ]
[ 16475-29-9 ]
[ 35856-62-3 ]

Reference： [1]Bulletin de la Societe Chimique de France,1936,vol. <5> 3,p. 2143,2146, 2149, 2150

2
[ 110-89-4 ]
[ 35856-62-3 ]

Yield	Reaction Conditions	Operation in experiment
70%	With sulfuryl dichloride; triethylamine; In dichloromethane; at 0 - 20℃; for 2h;	Example 1: Piperidine-l-sulfonyl chloride To a solution of sulfurylchloride (238 g, 1.76 moles) in dichloromethane (500 ml), a mixture of piperidine (100 g, 1.17 moles) and triethylamine (178 g, 1.76 moles) in dichloromethane (500 ml) was added at 0 C - 5 C. The reaction mass was warmed to room temperature, stirred for 2 hours, and quenched in ice cold water. After washing with water (2 x 5 volumes), the organic layer was separated organic layer. The reaction mass was dried over sodium sulfate and solvent evaporated off to obtain oily residue (151.3g, 70% yield). The FontWeight="Bold" FontSize="10" H NMR spectra of the resulting solid was obtained to reveal the following spectral peaks: FontWeight="Bold" FontSize="10" H NMR (300 MHz, CDC13) delta =1.58-1.62(m, 2H), 1.69- 1.83(m, 4H), 3.31-3.42(m, 4H)
46%	With sulfuryl dichloride; In diethyl ether; at -78 - 20℃; for 3h;	To 0.95mL (11. 7mmol) of sulfuryl chloride in 20 mL ether was added dropwise 2.3mL (23. 4mmol) of piperidine at-78 C. The reaction was stirred at rt for 3hrs. The insoluble solid was removed by filtration and the filtrate was washed with 1 N HCI, sat NaHCO3 and brine. The organic layer was dried over MgS04, filtered and the filtrate was concentrated to dryness to give 1. 00g of 10004b. yield 46%
	With sulfuryl dichloride; In dichloromethane; at 0 - 20℃; for 17h;	A solution of piperidine (300 mg, 3.5 mmol) in CH2Cl2 (10 ml) was added at 0C over 30 minutes to a suspension of sulfuryl dichloride (952 mg, 7.0 mmol) in CH2Cl2 (35 ml) and the whole was stirred at room temperature for 17 hours. The resulting solid was filtered off and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (15 ml), l-(4-fluorophenyl)-3-(piperidin-4-yljoxy)urea hydrochloride (130 mg, 0.45 mmol) and N,N-diisopropylethylamine (174 mg, 1.35 mmol) was added, and the whole was stirred at 50C for 24 hours. The reaction mixture was concentrated in vacuo and the residue was diluted with ethyl acetate (50 ml), washed with H2O (20 ml x 2), brine (20 ml x 2), dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (ethyl acetate/ petroleum ether: 50/50) to give 1 -(4-fluorophenyD- 3-d -(piperidin- 1 -ylsulfonyl)piperidin-4-yloxy)urea (90 mg, 50 %) as a white solid: LCMS: 401 [M+l]+. 1HNMR (DMSO-d6) delta: 1.48 (s, 6H), 1.7 (m, 2H), 1.89 (m, 2H), 2.98 (m, 2H), 3.1 (m, 4H), 3.4 (m, 2H), 3.87 (m, IH), 7.08 (t, 2H), 7.86 (m, 2H), 8.65 (s, IH), 9.42 (s, IH).

Reference： [1]Patent: WO2015/83066,2015,A1 .Location in patent: Page/Page column 11-12
[2]Journal of Fluorine Chemistry,1982,vol. 20,p. 425 - 438
[3]Patent: WO2005/87721,2005,A2 .Location in patent: Page/Page column 81-82
[4]Archiv der Pharmazie,1958,vol. 291,p. 7,11
[5]Archiv der Pharmazie,1958,vol. 291,p. 7,11
[6]Journal of the Chemical Society. Perkin transactions II,1984,p. 499 - 502
[7]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 3367 - 3370
[8]Patent: WO2009/151152,2009,A1 .Location in patent: Page/Page column 89

3
[ 2156-71-0 ]
[ 35856-62-3 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1959,vol. 624,p. 25,29

4
[ 35856-62-3 ]
[ 123-08-0 ]
[ 100391-95-5 ]

Reference： [1]Patent: DE1016256,1955,

5
[ 35856-62-3 ]
[ 6098-34-6 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 7,11

6
[ 35856-62-3 ]
[ 63698-83-9 ]

Reference： [1]Journal of Fluorine Chemistry,1982,vol. 20,p. 425 - 438
[2]Patent: DE667544,1935,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 25,p. 1347

7
[ 35856-62-3 ]
[ 15822-61-4 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 7,11

8
[ 35856-62-3 ]
[ 98138-30-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426
[2]Chemistry - A European Journal,2018,vol. 24,p. 19156 - 19161

9
[ 35856-62-3 ]
[ 1020-49-1 ]

Reference： [1]Bulletin de la Societe Chimique de France,1936,vol. <5> 3,p. 2143,2146, 2149, 2150

10
[ 120-93-4 ]
[ 35856-62-3 ]
[ 56302-32-0 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1982,vol. 21,p. 928 - 940

11
[ 35856-62-3 ]
[ 18004-75-6 ]
[ 76495-39-1 ]

Reference： [1]Liebigs Annalen der Chemie,1982,vol. No. 9,p. 1656 - 1676

12
[ 35856-62-3 ]
[ 14315-16-3 ]
[ 90233-68-4 ]

Reference： [1]Journal of Medicinal Chemistry,1986,vol. 29,p. 417 - 423

13
[ 35856-62-3 ]
[ 5307-14-2 ]
[ 105168-40-9 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

14
[ 35856-62-3 ]
[ 109-89-7 ]
Piperidine-1-sulfonic acid diethylamide [ No CAS ]

Reference： [1]Journal of Fluorine Chemistry,1982,vol. 20,p. 425 - 438

15
[ 35856-62-3 ]
[ 99-52-5 ]
[ 105168-51-2 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

16
[ 35856-62-3 ]
[ 56891-59-9 ]
[ 105168-60-3 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

17
[ 35856-62-3 ]
[ 57556-49-7 ]
[ 105168-75-0 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

18
[ 35856-62-3 ]
[ 35946-89-5 ]
C₅H₁₀NO₂S [ No CAS ]

Reference： [1]Journal of Chemical Research, Miniprint,1980,p. 2610 - 2623

19
[ 35856-62-3 ]
[ 106-44-5 ]
N-(4-methylphenoxysulfonyl)-piperidine [ No CAS ]

Reference： [1]Phosphorus and Sulfur and the Related Elements,1984,vol. 20,p. 371 - 376

20
[ 35856-62-3 ]
[ 92-69-3 ]
[ 72119-31-4 ]

Reference： [1]Phosphorus and Sulfur and the Related Elements,1984,vol. 20,p. 371 - 376

21
[ 35856-62-3 ]
[ 106-48-9 ]
N-(4-chlorophenoxysulfonyl)-piperidine [ No CAS ]

Reference： [1]Phosphorus and Sulfur and the Related Elements,1984,vol. 20,p. 371 - 376

22
[ 35856-62-3 ]
[ 108-95-2 ]
[ 1020-49-1 ]

Reference： [1]Phosphorus and Sulfur and the Related Elements,1984,vol. 20,p. 371 - 376

23
[ 686268-24-6 ]
[ 35856-62-3 ]
piperidine-1-sulfonic acid {3-[4-hydroxy-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-amide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 3367 - 3370

24
[ 35856-62-3 ]
[ 454218-37-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 3235 - 3240

25
[ 35856-62-3 ]
(2-hydroxy-2-pyridin-3-yl-ethyl)-{2-[4-(piperidine-1-sulfonylamino)-phenyl]-ethyl}-carbamic acid <i>tert</i>-butyl ester [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 3235 - 3240

26
[ 35856-62-3 ]
N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-1-piperidinesulfonamide, dihydrochloride [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 3235 - 3240

27
[ 35856-62-3 ]
Piperidine-1-sulfonic acid [(5S,5aS,8aR,9R)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-amide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2004,vol. 47,p. 2365 - 2374

28
[ 35856-62-3 ]
[ 105168-61-4 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

29
[ 35856-62-3 ]
[ 105168-52-3 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

30
[ 35856-62-3 ]
[ 105168-76-1 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

31
[ 35856-62-3 ]
[ 105168-43-2 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

32
[ 35856-62-3 ]
[5-(Piperidine-1-sulfonylamino)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester [ No CAS ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

33
[ 35856-62-3 ]
[4-Methyl-6-(piperidine-1-sulfonylamino)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester [ No CAS ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

34
[ 35856-62-3 ]
[5-Methyl-6-(piperidine-1-sulfonylamino)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester [ No CAS ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

35
[ 35856-62-3 ]
[ 105168-62-5 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

36
[ 35856-62-3 ]
[ 105168-53-4 ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

37
[ 35856-62-3 ]
C₁₆H₂₂ClN₅O₆S [ No CAS ]

Reference： [1]Journal of Chemical Research, Miniprint,1986,p. 1676 - 1686

38
[ 35856-62-3 ]
Piperidine-1-sulfonic acid diethylamide [ No CAS ]

Reference： [1]Journal of Fluorine Chemistry,1982,vol. 20,p. 425 - 438

39
[ 35856-62-3 ]
[ 56302-33-1 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1982,vol. 21,p. 928 - 940

40
[ 35856-62-3 ]
[ 15822-60-3 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 7,11
[2]Archiv der Pharmazie,1958,vol. 291,p. 7,11

41
[ 35856-62-3 ]
[ 15822-64-7 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 7,11

42
[ 35856-62-3 ]
[ 99904-04-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

43
[ 35856-62-3 ]
[ 99993-01-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

44
[ 35856-62-3 ]
[ 100318-56-7 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

45
[ 35856-62-3 ]
[ 100318-73-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

46
[ 35856-62-3 ]
[ 100451-22-7 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426
[2]Chemistry - A European Journal,2018,vol. 24,p. 19156 - 19161

47
[ 35856-62-3 ]
[ 100318-75-0 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

48
[ 35856-62-3 ]
[ 99993-09-6 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

49
[ 35856-62-3 ]
[ 109535-87-7 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

50
[ 35856-62-3 ]
[ 100140-41-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

51
[ 35856-62-3 ]
[ 109645-71-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 426

52
[ 35856-62-3 ]
1-methyl-piperidine; compound with sulfur trioxide [ No CAS ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 7,11

53
[ 35856-62-3 ]
[ 112658-36-3 ]

Reference： [1]Journal of the American Chemical Society,1960,vol. 82,p. 3437 - 3441

54
3(R)-[2-(4-amino-phenyl)-1,1-dimethyl-ethyl]-5-(3-chloro-phenyl)-oxazolidin-2-one [ No CAS ]
[ 35856-62-3 ]
[ 454219-01-3 ]

Reference： [1]Patent: EP1236723,2002,A1 .Location in patent: Page 20

55
[ 35856-62-3 ]
[ 160232-08-6 ]
C₂₄H₄₁N₃O₅S [ No CAS ]

Reference： [1]Patent: US6372778,2002,B1 .Location in patent: Example 150

56
[ 110-85-0 ]
[ 35856-62-3 ]

Reference： [1]Patent: US6372778,2002,B1 .Location in patent: Example 150

57
[ 35856-62-3 ]
[ 290815-01-9 ]
[ 865452-94-4 ]

Yield	Reaction Conditions	Operation in experiment
60%	With triethylamine; In dichloromethane; at 20℃;	To 0.350g (1. 62mmol) of 10001a in 1 OmL CH2CI2 was added 0.23 mL (1. 62mmol) of Et3N, then 0.446g (2. 42mmol) of 10004b in 5 mL CH2CI2 drop wise at rt. The reaction mixture was stirred at rt overnight. The reaction mixture was diluted with EtOAc, washed with a solution of aq. NH4CI and brine. The organic layers was dried over MgS04, filtered, concentrated in vacuo and purified by silica gel chromatography with 6 24% EtOAc in Hexane to yield 0.353g of product. Yield 60%.

Reference： [1]Patent: WO2005/87721,2005,A2 .Location in patent: Page/Page column 82

58
[ 35856-62-3 ]
[ 41995-29-3 ]
piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; for 15h;Heating / reflux;	Example 25 Piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide A solution of 6-propyl-pyridin-2-ylamine (0.2 g) and <strong>[35856-62-3]piperidine-1-sulfonyl chloride</strong> (0.296 g, Bull. Soc. Chim. Fr.; 1936, 2143) in pyridine (7 mL) was heated to reflux for 15 h. After concentration of the reaction mixture in vacuo the residue was taken up in EtOAc, which was then washed with 1N aqueous HCl, saturated brine, dried over sodium sulphate and concentrated in vacuo. The residue was applied to a silica gel column with EtOAc/toluene (9:1 to 1:1) as eluent. Combination of the purified fractions and concentration in vacuo gave the desired piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide (0.133 g) as a colorless amorphous solid. MS (ESI-): 282.0 ([M-H]-).

Reference： [1]Patent: US2006/74237,2006,A1 .Location in patent: Page/Page column 17

59
5-(2,4-dichloro-phenyl)-pyridin-2-ylamine [ No CAS ]
[ 35856-62-3 ]
piperidine-1-sulfonic acid [5-(2,4-dichloro-phenyl)-pyridin-2-yl]-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	With pyridine; for 20h;Heating / reflux;	A solution of 0.23 g (1 mmol) of 5-(2,4-dichloro-phenyl)-pyridin-2-ylamine and 0.2 g (1.1 mmol) of <strong>[35856-62-3]piperidine-1-sulfonyl chloride</strong> (preparation: Bull. Soc. Chim. Fr.; 1936, p2143) in pyridine (10 ml) was heated to reflux until completion of reaction according to HPLC analysis (20 h). After concentration in vacuo the residue was taken up in EtOAc, which was then washed with 1N aqueous HCl, saturated brine, dried over sodium sulphate and concentrated in vacuo. The residue was applied to a silica gel column with EtOAc/toluene (9/1 to 1/1) as eluent. Combination of the purified fractions and concentration in vacuo gave 0.26 g (67%) of the desired piperidine-1-sulfonic acid [5-(2,4-dichloro-phenyl)-pyridin-2-yl]-amide as a brown crystalline solid. ISN mass spectrum, m/e: 384 (M-1 calculated for C16H17Cl2N2O2S: 384).

Reference： [1]Patent: US2006/25455,2006,A1 .Location in patent: Page/Page column 15

60
[ 120-93-4 ]
[ 35856-62-3 ]
methanol-isopropanol [ No CAS ]
[ 56302-32-0 ]

Yield	Reaction Conditions	Operation in experiment
		To 17.4 of ethyleneurea is added with shaking 36 g of piperidinosulfonyl chloride (b.p. 130/11m) and the mixture kept under nitrogen at 100 for 3 hrs. The mixture is cooled and the gummy material treated with methanol-isopropanol (1:1) to give a granular product of 1-piperidinosulfonyl-2-oxo-tetrahydroimidazole which melts at 201 on recrystallization from methanol.

Reference： [1]Patent: US3976778,1976,A

61
[ 35856-62-3 ]
[ 221532-98-5 ]
2,2,2-trifluoro-N-[4-(1-piperidinesulfonylpiperidin-4-ylmethyl)-phenyl]acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane;	Step 4 A solution of 2,2,2-trifluoro-N-(4-(piperidin-4-ylmethyl)-phenyl]acetamide (0.5 g, 1.75 mmol) (prepared as previously described in Example 19, steps 1 to 3) and triethylamine in dichloromethane (10 mL) was cooled in an ice bath under a nitrogen atmosphere. The mixture was then treated with a solution of <strong>[35856-62-3]1-piperidinesulfonyl chloride</strong> (0.39 g, 2.09 mmol) in dichloromethane (1 mL). The reaction mixture was stirred for 1.5 hours at 0-5 C. and quenched with water. The organic layer was separated, and the aqueous layer extracted with dichloromethane. The combined organic extracts were washed with water and brine, dried, and solvents removed in vacuo. The residue was chromatographed on silica gel, eluding with 30% ethyl acetate/hexanes, to give 2,2,2-trifluoro-N-[4-(1-piperidinesulfonylpiperidin-4-ylmethyl)-phenyl]acetamide (0.48 g) as a white solid, m.p. 156-157 C.; Analysis for C19H26N3O3SF3: Calc.: C, 52.64; H, 6.05; N, 9.69; Found: C, 52.84; H, 6.00; N, 6.79.

Reference： [1]Patent: US6184242,2001,B2

62
[ 35856-62-3 ]
[ 1010816-09-7 ]
[ 1010816-04-2 ]

Reference： [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 861 - 874

63
[ 35856-62-3 ]
[ 1055306-88-1 ]
[ 1055307-13-5 ]

Yield	Reaction Conditions	Operation in experiment
45%		Reference Example 100; tert-butyl { [4-fluoro-5- (2-fluoropyridin-3-yl) -1- (piperidin-1- ylsulfonyl ) -lH-pyrrol-3-yl ]methyl }methylcarbamate; To a solution of tert-butyl { [4-fluoro-5- (2- fluoropyridin-3-yl) -lH-pyrrol-3-yl]methyl}methylcarbamate (324 mg) in tetrahydrofuran (20 mL) was added sodium hydride (60% in oil, 121 mg) at room temperature and the mixture was stirred for 15 min. 15-Crown-5 (664 mg) was added dropwise, and the mixture was stirred for 5 min. Piperidine-1-sulfonyl chloride (240 mg) was added, and the mixture was further stirred for 3 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified <n="133"/>by silica gel column chromatography (eluent: hexane-ethyl acetate=l: 4?1: 1) to give the title compound as a colorless oil (yield 210' mg, 45%) .1H-NMR (CDCl3) delta: 1.45(6H,br), 1.49(9H,s), 2.88(4H,br), 2.91(3H,s), 4.29(2H,brs), 7.12 (IH, d, J=4.9Hz) , 7.25-7.30 (lH,m) , 7.86-7.98 ( IH,m), 8.26 (IH, d, J=4.2Hz) .

Reference： [1]Patent: WO2008/108380,2008,A2 .Location in patent: Page/Page column 131-132

64
[ 35856-62-3 ]
[ 1104027-48-6 ]
[ 1104026-75-6 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃;	[00348] Into a 20 ml reaction vessel was combined N-(quinolin-3-yl)-5,6,7,8-tetrahydro-2,6- naphthyridin-1 -amine (7.0 mg, 0.025 mmol) NN-diisopropylethylamine (13.2 uL, 0.0760 mmol) and NN- Dimethylformamide (600 uL, 8 mmol). Piperidine-1-sulfonyl chloride (6.98 mg, 0.0380 mmol) was added dropwise and the mixture was allowed to stir at room tmeperature for 30 minutes. The was purified directly by reversed phase HPLC (acetonitrileiwater gradient) at pHIO using nu-ethylethanamine (2.62 uL, 0.0253 mmol) as a buffer. The combined pure fractions were reduced invacuo to afford the title compound

Reference： [1]Patent: WO2009/11904,2009,A1 .Location in patent: Page/Page column 74

65
[ 35856-62-3 ]
[ 1200798-08-8 ]
[ 1200797-51-8 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 50℃; for 24h;	A solution of piperidine (300 mg, 3.5 mmol) in CH2Cl2 (10 ml) was added at 0C over 30 minutes to a suspension of sulfuryl dichloride (952 mg, 7.0 mmol) in CH2Cl2 (35 ml) and the whole was stirred at room temperature for 17 hours. The resulting solid was filtered off and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (15 ml), l-(4-fluorophenyl)-3-(piperidin-4-yljoxy)urea hydrochloride (130 mg, 0.45 mmol) and N,N-diisopropylethylamine (174 mg, 1.35 mmol) was added, and the whole was stirred at 50C for 24 hours. The reaction mixture was concentrated in vacuo and the residue was diluted with ethyl acetate (50 ml), washed with H2O (20 ml x 2), brine (20 ml x 2), dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (ethyl acetate/ petroleum ether: 50/50) to give 1 -(4-fluorophenyD- 3-d -(piperidin- 1 -ylsulfonyl)piperidin-4-yloxy)urea (90 mg, 50 %) as a white solid: LCMS: 401 [M+l]+. 1HNMR (DMSO-d6) delta: 1.48 (s, 6H), 1.7 (m, 2H), 1.89 (m, 2H), 2.98 (m, 2H), 3.1 (m, 4H), 3.4 (m, 2H), 3.87 (m, IH), 7.08 (t, 2H), 7.86 (m, 2H), 8.65 (s, IH), 9.42 (s, IH)

Reference： [1]Patent: WO2009/151152,2009,A1 .Location in patent: Page/Page column 89

66
[ 35856-62-3 ]
[ 57260-71-6 ]
[ 1228106-16-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 2577 - 2581

67
[ 35856-62-3 ]
C₂₀H₂₀ClF₂NO₃S [ No CAS ]
[ 1237802-26-4 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3632 - 3635

68
[ 273-53-0 ]
[ 35856-62-3 ]
[ 2851-09-4 ]

Yield	Reaction Conditions	Operation in experiment
33%	With potassium dichromate; dichloro(2,2'-bipyridine)palladium(II); copper(l) cyanide; potassium carbonate; In chlorobenzene; at 150℃; for 24h;Sealed tube; Molecular sieve;	General procedure: Under air, a reaction tube was charged with benzoxazole (0.2 mmol), dimethylsulfamoyl chloride (0.3 mmol), BipyPdCl2 (10 mol %), CuCN (20 mol %), K2CO3 (0.4 mmol), K2Cr2O7 (0.2 mmol) and dry PhCl (2 mL). The mixture was stirred at 150 o C for 24 h. After the completion of the reaction, monitored by TLC, the solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography on silica gel to give the product.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 6297 - 6299,3

69
[ 35856-62-3 ]
[ 1402889-82-0 ]

Reference： [1]Patent: WO2012/139775,2012,A1

70
[ 35856-62-3 ]
[ 1403387-94-9 ]

Reference： [1]Patent: WO2012/139775,2012,A1

71
[ 35856-62-3 ]
[ 1403387-95-0 ]

Reference： [1]Patent: WO2012/139775,2012,A1

72
[ 35856-62-3 ]
[ 1403387-96-1 ]

Reference： [1]Patent: WO2012/139775,2012,A1

73
[ 35856-62-3 ]
[ 1403387-97-2 ]

Reference： [1]Patent: WO2012/139775,2012,A1

74
[ 35856-62-3 ]
C₂₄H₃₅ClN₂O₄S₂ [ No CAS ]

Reference： [1]Patent: WO2012/139775,2012,A1

75
[ 35856-62-3 ]
[ 1018652-50-0 ]
[ 1425927-12-3 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; dmap; at 60℃; for 16h;	General procedure: This compound was prepared in a parallel synthesis format according to the following procedure. A 0.2 M solution of 6-amino-3-methyl-1 H-quinolin-2-one in anhydrous pyridine was prepared (Solution A). A 0.2 M solution of each sulfonyl chloride monomer, for example piperidine 1 -sulfonyl chloride, in anhydrous pyridine was likewise prepared. These sulfonyl chloride solutions were prepared freshly just before use. Solution A (500 uL, 100 muiotatauiotaomicronbeta) was added to each reaction vial, followed by 500 mu (1 equivalent, 100 umole) of sulfonyl chloride solution, with each sulfonyl chloride being unique to each vial in the library. Each vial was treated with 12 mg (100 umole) of DMAP, after which the vials were stirred for 16 h at 60 C. The reaction mixtures were evaporated in a Thermo Explorer (2 hr, 5 torr, at 45 C). Each of the crude products was dissolved in 1 mL of DMSO. 10 mu of the DMSO solution was diluted to 200 mu with DMSO for QC analysis and the remaining amount was submitted for prep-HPLC purification on a Waters Autopurification System using a gradient of 0.05% formic acid in water and acetonitrile. Product fractions were evaporated to dryness and weighed. For 46: Calculated molecular weight 321 .1 1 ; found MH+ 322.05.

Reference： [1]Patent: WO2013/27168,2013,A1 .Location in patent: Page/Page column 56-57

76
[ 35856-62-3 ]
C₁₄H₁₄N₂S*ClH [ No CAS ]
C₁₉H₂₃N₃O₂S₂ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 4037 - 4043

77
[ 35856-62-3 ]
[ 1429242-17-0 ]
[ 1429240-37-8 ]

Reference： [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 9920 - 9933

78
[ 35856-62-3 ]
C₁₈H₁₆ClN₃O [ No CAS ]
[ 1567373-01-6 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2053 - 2056

79
[ 473269-70-4 ]
[ 35856-62-3 ]
N-(3-amino-5-(tert-butyl)-2-methoxyphenyl)piperidine-1-sulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
135 mg	With pyridine; In tetrahydrofuran; at 0 - 20℃; for 144h;	To a stirred solution of 5-(tert-butyl)-2-methoxybenzene-1,3-diamine (150 mg, 0.772 mmol) in DCM (4 mL) at 0-5 C., was added pyridine (440 muL, 5.44 mmol) then <strong>[35856-62-3]piperidine-1-sulfonyl chloride</strong> (108 muL, 0.772 mmol). The mixture was warmed to rt and stirred for 6 days. The reaction was concentrated in vacuo and the residue azeotroped with toluene (2*10 mL). The residue was dissolved in a mixture of DCM and MeOH and concentrated in vacuo onto silica gel. The crude product was purified by chromatography on the Companion (40 g column, 1-2% MeOH in DCM, detecting at 225 nm) to afford a yellow solid. The material was re-purified by chromatography on the Companion (12 g column, 1-5% THF in DCM, detecting at 225 nm) to afford the sub-title compound (135 mg) as a pale yellow solid. LCMS m/z 342 (M+H)+ (ES+); 340 (M-H)- (ES-)
135 mg	With pyridine; In dichloromethane; at 0 - 20℃; for 144h;	To a stirred solution of 5-(tert-butyl)-2-methoxybenzene-1,3-diamine (150 mg, 0.772 mmol) inDCM (4 mL) at 0-5 o was added pyridine (440 pL, 5.44 mmol) then piperidine-1-sulfonylchloride (108 pL, 0.772 mmol). The mixture was warmed to rt and stirred for 6 days. Thereaction was concentrated in vacuo and the residue azeotroped with toluene (2 x 10 mL).The residue was dissolved in a mixture of DCM and MeOH and concentrated in vacuo onto silica gel. The crude product was purified by chromatography on the Companion (40 g column, 1-2% MeOH in DCM, detecting at 225 nm) to afford a yellow solid. The material was re-purified by chromatography on the Companion (12 g column, 1-5% THF in DCM, detectingat 225 nm) to afford the sub-title compound (135 mg) as a pale yellow solid. LCMS mlz 342 (M+H) (ES); 340 (M-H) (ES)

Reference： [1]Patent: US2014/296208,2014,A1 .Location in patent: Paragraph 1237; 1238
[2]Patent: WO2014/162126,2014,A1 .Location in patent: Page/Page column 138

80
[ 473269-70-4 ]
[ 35856-62-3 ]
N-(5-(tert-butyl)-2-methoxy-3-(3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)ureido)phenyl)piperidine-1-sulfonamide [ No CAS ]

Reference： [1]Patent: US2014/296208,2014,A1
[2]Patent: WO2014/162126,2014,A1

81
[ 35856-62-3 ]
C₂₈H₄₀N₄O₄S₂ [ No CAS ]

Reference： [1]Patent: WO2015/83066,2015,A1

82
[ 35856-62-3 ]
[ 73058-30-7 ]
(S)-1-((2-benzylaziridin-1-yl)sulfonyl)piperidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -5 - 5℃; for 18h;	Example 2: Piperidine sulfamoyl aziridine of formula 9 Piperidine-l-sulfonyl chloride (138 g, 0.75 moles) was added to a cooled solution of 2- (S)-benzyl aziridine (100 g, 0.75 moles) in dichloromethane (300 ml), followed by N,N- diisiopropylethylamine (102 g, 0.79 moles) at -5 to 5 C. The reaction mass was stirred at same temperature for 18 hours, quenched with 5% aqueous citric acid solution, and the organic layer was separated after washing with 5% aqueous sodium bicarbonate solution. The separated organic layer was evaporated off and the product was isolated in isopropyl alcohol to yield a white solid (136.5 g, 65% yield). The FontWeight="Bold" FontSize="10" H NMR spectra of the resulting solid was obtained to reveal the following spectral peaks: FontWeight="Bold" FontSize="10" H NMR (300 MHz, CDC13) delta = 1.38-1.58(m, 6H), 2.10-2.12(d, 1H), 2.53--2.55(d, 1H), 2.67--2.74(m, 1H), 2.78- 2.96(m, 4H), 3.07-3.14(m, 2H), 7.24-7.36(m, 5H)

Reference： [1]Patent: WO2015/83066,2015,A1 .Location in patent: Page/Page column 12

83
[ 35856-62-3 ]
C₁₉H₂₀N₆O₂S*2ClH [ No CAS ]
[ 1201191-15-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 4399 - 4404

84
[ 35856-62-3 ]
C₁₉H₂₀N₆O₂S*2ClH [ No CAS ]
[ 1201183-26-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 4399 - 4404

85
[ 35856-62-3 ]
(S)-ethyl 2-(tert-butoxy)-2-(4,7-dimethyl-6-(p-tolyl)isoindolin-5-yl)acetate [ No CAS ]
(2S)-ethyl 2-(tert-butoxy)-2-(4,7-dimethyl-2-(piperidin-1-ylsulfonyl)-6-(p-tolyl)isoindolin-5-yl)acetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With triethylamine; for 1h;	Sterj 1: (2S)-ethyl 2-(tert-butoxy)-2-(4,7-dimethyl-2-(rjirjeridin-1 -ylsulfonyl)-6-(rj-tolyl)isoindolin-5- yI)acetate. A solution of (S)-ethyl 2-(tert-butoxy)-2-(4,7-dimethyl-6-(p-tolyl) isoindolin-5-yl)acetate (45 mg, 0.114 mmol) and triethylamine (1.5 eq, 0.341 mmol, 0.048 mL) was treated dropwise with piperidine-1 -sulfonyl chloride (1.5 eq, 0.171 mmol, 0.024 mL added). After 1 h, the reaction mixture was diluted with sat. aq. NaHCO3 and the phases separated. The aqueous layer was extracted with DCM (x3), and the combined organics were washed with brine, dried, filtered, and concentrated in vacuo. The crude material was purified by silica gel chromatography (0-100% EtOAc-hexanes) to afford the title compound (24 mg, 51%) as a light red oil. 1H NMR(400 MHz, ODd3) 57.26-7.18 (m, 3H), 7.05-7.03 (m, 1H), 4.97 (s, 1H), 4.66 (s, 4H), 4.20-4.07(m, 2H), 3.29-3.27 (m, 4H), 2.42 (s, 3H), 2.29 (s, 3H), 1 .82 (s, 3H), 1 .66-1 .56 (m, 6H), 1 .23 (t,3H), 0.96 (s, 9H). LCMS(ES+)(m/z): 543.42 (M+1).

Reference： [1]Patent: WO2016/5878,2016,A1 .Location in patent: Page/Page column 45; 46

86
[ 35856-62-3 ]
(S)-ethyl 2-(tert-butoxy)-2-(4,7-dimethyl-6-(p-tolyl)isoindolin-5-yl)acetate [ No CAS ]
(2S)-2-(tert-butoxy)-2-[4,7-dimethyl-6-(4-methylphenyl)-2-(piperidine-1-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]acetic acid [ No CAS ]

Reference： [1]Patent: WO2016/5878,2016,A1

87
[ 35856-62-3 ]
C₁₆H₁₉N₃O₂ [ No CAS ]
C₂₁H₂₈N₄O₄S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,p. 3905 - 3912

88
[ 35856-62-3 ]
C₁₆H₁₉N₃O₂ [ No CAS ]
C₂₁H₂₈N₄O₄S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,p. 3905 - 3912

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 35856-62-3 ] {[proInfo.proName]}

Quality Control of [ 35856-62-3 ]

Related Doc. of [ 35856-62-3 ]

Product Details of [ 35856-62-3 ]

Calculated chemistry of [ 35856-62-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 35856-62-3 ]

Application In Synthesis of [ 35856-62-3 ]

[ 35856-62-3 ] Synthesis Path-Upstream 1~6

[ 35856-62-3 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 35856-62-3 ]

Sulfonyl Chlorides

Chlorides

Sulfamides

Related Parent Nucleus of [ 35856-62-3 ]

Piperidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 35856-62-3 ]

Related Parent Nucleus of
[ 35856-62-3 ]