Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
*Storage: {[proInfo.prStorage]}
CAS No. : | 36234-66-9 | MDL No. : | MFCD21117211 |
Formula : | C7H8N2OS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 168.22 | Pubchem ID : | 21941906 |
Synonyms : |
|
TPSA :Topological Polar Surface Area | 84.2 | H-Bond Acceptor Count : | 4 |
XLogP3 : | 1.1 | H-Bond Donor Count : | 1 |
SP3 : | 0.43 | Rotatable Bond Count : | 0 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
![]() |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | for 15 h; Reflux | General procedure: A mixture of 3-bromocyclohexane-1,2-dione 3 (50 mg, 0.26 mmol) and pyridine-4-carbothioamide (24.1 mg, 0.17 mmol) in EtOH (0.69 mL) was heated to reflux and stirred for 15 h. The reaction mixture was diluted with DMSO (0.5 mL) to completely dissolve all solids and the resulting mixture was purified by directly injecting the reaction mixture into a preparatory HPLC (C18, water/acetonitrile/ammonium acetate buffer) to give 2-(pyridin-4-yl)-6,7-dihydrobenzo[d]thiazol-4(5H)-one (30.4 mg, 0.13 mmol, 76percent) (Table 1, entry 1). |
47% | at 90℃; for 16 h; | Int-35 (5.0 g, 26.17 mmol) was dissolved in EtOH (50 mL) and thiourea (1.99 g, 26.17 mmol) was added at rt. Then the mixture was heated at 90 °C for 16 h. After cooling down to rt, the mixture was concentrated under reduced pressure and the residue was diluted with water (50 mL) and extracted with EtOAc (2 x 150 mL). Combined organic layers were washed with water (50 mL), brine (50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by colunm chromatography on reversed phase silica gel using water/acetonitrile with 0.01percent formic acid as eluent. 2-Amino-6,7-dihydrobenzo[d]thiazol-4(5H)-one (int-36) was obtained as an off-white solid in 47percent (2.1 g) yield. MS (ESI) mlz 169.01 [M-H]. |
[ 17583-10-7 ]
2-Amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one
Similarity: 0.89
[ 40353-62-6 ]
1-(2-Amino-5-methylthiazol-4-yl)ethanone
Similarity: 0.89
[ 2933-29-1 ]
2-Amino-4,5,6,7-tetrahydrobenzothiazole
Similarity: 0.84
[ 104617-49-4 ]
4,5,6,7-Tetrahydrobenzo[d]thiazole-2,6-diamine
Similarity: 0.80
[ 106092-11-9 ]
(R)-4,5,6,7-Tetrahydro-benzothiazole-2,6-diamine
Similarity: 0.80
[ 17583-10-7 ]
2-Amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one
Similarity: 0.89
[ 40353-62-6 ]
1-(2-Amino-5-methylthiazol-4-yl)ethanone
Similarity: 0.89
[ 935850-03-6 ]
5,6-Dihydrobenzo[d]thiazol-7(4H)-one
Similarity: 0.79
[ 1368187-44-3 ]
1-(5-Methylthiazol-4-yl)ethanone
Similarity: 0.76
[ 94284-66-9 ]
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone
Similarity: 0.76
[ 17583-10-7 ]
2-Amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one
Similarity: 0.89
[ 2933-29-1 ]
2-Amino-4,5,6,7-tetrahydrobenzothiazole
Similarity: 0.84
[ 104617-49-4 ]
4,5,6,7-Tetrahydrobenzo[d]thiazole-2,6-diamine
Similarity: 0.80
[ 106092-11-9 ]
(R)-4,5,6,7-Tetrahydro-benzothiazole-2,6-diamine
Similarity: 0.80
[ 935850-03-6 ]
5,6-Dihydrobenzo[d]thiazol-7(4H)-one
Similarity: 0.79