Home Cart 0 Sign in  

[ CAS No. 3705-87-1 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 3705-87-1
Chemical Structure| 3705-87-1
Structure of 3705-87-1 *Storage: {[proInfo.prStorage]}

Quality Control of [ 3705-87-1 ]

Related Doc. of [ 3705-87-1 ]

SDS
Alternatived Products of [ 3705-87-1 ]
Alternatived Products of [ 3705-87-1 ]

Product Details of [ 3705-87-1 ]

CAS No. :3705-87-1MDL No. :MFCD00456409
Formula : C10H11ClN2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :194.66Pubchem ID :13061697
Synonyms :

Computed Properties of [ 3705-87-1 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 3705-87-1 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P280-P304+P340-P305+P351+P338-P405UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 3705-87-1 ]

  • Downstream synthetic route of [ 3705-87-1 ]

[ 3705-87-1 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 612-81-7 ]
  • [ 3705-87-1 ]
  • [ 206009-44-1 ]
  • 4
  • [ 3705-87-1 ]
  • 4'-(1-Isopropyl-1H-benzoimidazol-2-yl)-[2,3']biquinolinyl [ No CAS ]
  • 5
  • [ 123-51-3 ]
  • [ 6091-44-7 ]
  • [ 3705-87-1 ]
  • 2-[4-(5-Methyl-1H-imidazol-4-yl)piperidin-1-yl)-1-(1-methylethyl)-1H-benzimidazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium methylate; In methanol; dichloromethane; 3.7. 2-[4-(5-Methyl-1H-imidazol-4-yl)piperidin-1-yl]-1(1-methylethyl)-1H-benzimidazole. 34 ml (0.18 mole) of 5.3 N sodium methylate are added, under argon, to a suspension of 21.5 g (0.0904 mole) of the above compound in 100 ml of methanol. The mixture is stirred for 15 minutes and then concentrated under vacuum to two thirds its volume. 200 ml of dichloromethane are then added and sodium chloride is filtered off. The solution is concentrated under vacuum and the crystallized base is recovered. A solution of 400 ml of 3-methylbutan-1-ol and 8.8 g (0.0452 mole) of 2-chloro-l-(1-methylethyl)-1H-benzimidazole are then added. The mixture is heated at 120 C. by means of an oil bath for 24 hours. The precipitate of excess (6 g) <strong>[6091-44-7]<strong>[6091-44-7]piperidine</strong> hydrochloride</strong> (1:1) is filtered. The filtrate is evaporated to dryness and the residue is purified on a silica gel column eluding with a mixture of dichloromethane and methanol in proportions of 90:10 v/v. The pure fractions are combined and evaporated. The solid is washed with acetone and then dried under vacuum. 9.5 g of compound are obtained. Melting point: 258 C.
  • 6
  • [ 4857-06-1 ]
  • [ 67-68-5 ]
  • [ 3705-87-1 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In hexane; EXAMPLE 2 2-Chloro-1-(1-methylethyl)-1H-benzimidazole. 13.5 g (0.0885 mole) of 2-chloro-1H-benzimidazole, 9.2 ml of 1-bromo-1-methylethyl, 230 g of potassium carbonate and 200 ml of dimethyl sulphoxide are introduced into a round-bottom flask. The mixture is vigorously stirred for 4 hours while maintaining the temperature at 60 C. It is extracted several times with ether. The organic phases are combined and concentrated. The pasty residue is purified on a silica gel column eluding with a mixture of ethyl acetate and hexane in proportions of 20:80 v/v. The pure fractions are concentrated under vacuum. The residue is dissolved in 20 ml of hexane with the use of heat. The solution is cooled on a ice bath, the crystals are drained and then washed with a small amount of hexane and dried under vacuum. 12 g of compound are obtained. Melting point: 62 C.
Historical Records

Related Functional Groups of
[ 3705-87-1 ]

Chlorides

Chemical Structure| 58533-15-6

[ 58533-15-6 ]

2-Chloro-1-ethyl-1H-benzo[d]imidazole

Similarity: 0.96

Chemical Structure| 40019-65-6

[ 40019-65-6 ]

2-(2-Chloro-1H-benzo[d]imidazol-1-yl)ethanol

Similarity: 0.89

Chemical Structure| 43181-78-8

[ 43181-78-8 ]

1-Benzyl-2-chloro-1H-benzo[d]imidazole

Similarity: 0.86

Chemical Structure| 1416714-37-8

[ 1416714-37-8 ]

6-Bromo-2-chloro-1-cyclopropyl-1H-benzo[d]imidazole

Similarity: 0.84

Chemical Structure| 87233-54-3

[ 87233-54-3 ]

2-Chloro-1-(2-ethoxyethyl)-1H-benzo[d]imidazole

Similarity: 0.84

Related Parent Nucleus of
[ 3705-87-1 ]

Benzimidazoles

Chemical Structure| 58533-15-6

[ 58533-15-6 ]

2-Chloro-1-ethyl-1H-benzo[d]imidazole

Similarity: 0.96

Chemical Structure| 40019-65-6

[ 40019-65-6 ]

2-(2-Chloro-1H-benzo[d]imidazol-1-yl)ethanol

Similarity: 0.89

Chemical Structure| 43181-78-8

[ 43181-78-8 ]

1-Benzyl-2-chloro-1H-benzo[d]imidazole

Similarity: 0.86

Chemical Structure| 1416714-37-8

[ 1416714-37-8 ]

6-Bromo-2-chloro-1-cyclopropyl-1H-benzo[d]imidazole

Similarity: 0.84

Chemical Structure| 87233-54-3

[ 87233-54-3 ]

2-Chloro-1-(2-ethoxyethyl)-1H-benzo[d]imidazole

Similarity: 0.84