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Chemical Structure| 381666-22-4 Chemical Structure| 381666-22-4

Structure of 381666-22-4

Chemical Structure| 381666-22-4

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Product Details of [ 381666-22-4 ]

CAS No. :381666-22-4
Formula : C6H10N4O2
M.W : 170.17
SMILES Code : COC1=CN=C(OC)N=C1NN

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Application In Synthesis of [ 381666-22-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 381666-22-4 ]

[ 381666-22-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 370103-25-6 ]
  • [ 381666-22-4 ]
  • 2
  • [ 370103-25-6 ]
  • aqueous hydrazine [ No CAS ]
  • [ 381666-22-4 ]
YieldReaction ConditionsOperation in experiment
89% In methanol; 1. Preparation of 2,5-Dimethoxy-4-hydrazinopyrimidine A slurry of <strong>[370103-25-6]4-chloro-2,5-dimethoxypyrimidine</strong> (3.0 grams (g), 17.2 mmol) in methanol (15 milliliters (mL)) was treated with aqueous hydrazine (3.9 g of 35 wt. %, 42.5 mmol) in one portion causing a slow exotherm to 29 C. The reaction was then warmed to 50 C. and held at that temperature for 2 hours (h) at which time gas chromatography (GC) analysis indicated the reaction was complete. The clear solution was cooled to ambient temperature and allowed to stir overnight. The solvent was removed in vacuo and the resulting gummy solid was triturated with CH3CN (50 mL). The resulting mixture was filtered through a pad of silica gel (6 centimeter (cm)*6 cm). The pad was rinsed with CH3CN (550 mL). The filtrates were combined and the solvent removed in vacuo affording the title compound as a white solid (2.6 g, 89%): mp 115-117 C.; 1H NMR (300 MHz, DMSO-d6) 3.73 (s, 3H), 3.76 (s, 3H), 4.29 (bs, 2H), 7.51 (s, 1H), 8.23 (bs, 1H); MS(GC, 70 eV) 170 (M+, 100%), 155(55%), 151 (40%).
 

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