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Chemical Structure| 388630-66-8 Chemical Structure| 388630-66-8

Structure of 388630-66-8

Chemical Structure| 388630-66-8

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Product Details of [ 388630-66-8 ]

CAS No. :388630-66-8
Formula : C11H20N2O3
M.W : 228.29
SMILES Code : O=C(OC(C)(C)C)N[C@H]1C[C@@H](C(N)=O)CC1
MDL No. :MFCD28404337

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Application In Synthesis of [ 388630-66-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 388630-66-8 ]

[ 388630-66-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 261165-05-3 ]
  • [ 388630-66-8 ]
YieldReaction ConditionsOperation in experiment
23.2% Step D: Preparation of Carbamic acid, [(1S,3R)-3-(aminocarbonyl)cyclopentyl]-, 1,1-dimethylethyl ester. N,N'-carbonyl diimidazole (2.76 g, 17.0 mmol) was added to a solution of (1S,3R)-cyclopentanecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino] (1.32 g, 5.73 mmol) in THF (20 ml) and heated at 60 C. for 1 h. The reaction mixture was cooled to 0 C. and ammonium acetate (2.62 g, 34.0 mmol) was added. The reaction mixture was warmed to room temperature and stirred for 4 h. Water was added and extracted with ethyl acetate (2×30 ml). The combined organic layer was washed successively with water, brine, dried over anhydrous sodium sulfate and concentrated in vacuo to afford 1.3 g of crude. The crude compound was suspended in diethyl ether, stirred for 15 min, filtered, washed with diethyl ether and the solid was dried under reduced pressure to afford 300 mg (23.2%) of carbamic acid, [(1S,3R)-3-(aminocarbonyl)cyclopentyl]-, 1,1-dimethylethyl ester as white solid.
 

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