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[ CAS No. 3951-89-1 ]

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Chemical Structure| 3951-89-1
Chemical Structure| 3951-89-1
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Product Details of [ 3951-89-1 ]

CAS No. :3951-89-1 MDL No. :MFCD02168781
Formula : C10H10BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :240.10 g/mol Pubchem ID :-
Synonyms :

Safety of [ 3951-89-1 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 3951-89-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3951-89-1 ]

[ 3951-89-1 ] Synthesis Path-Downstream   1~30

  • 1
  • [ 3951-89-1 ]
  • [ 24424-99-5 ]
  • [ 313724-26-4 ]
YieldReaction ConditionsOperation in experiment
With 4-dimethylaminopyridine In tetrahydrofuran for 1.5h; Heating;
With luitdine In tetrahydrofuran at 70℃; for 4h; 2.3 Step 3: Synthesis of compound BB-1B-4 The reactants BB-1B-3 (6 g) and Boc anhydride (15.16 g) were dissolved in tetrahydrofuran (100 mL), and N,N-lutidine (4.58 g) was added to form a mixture. The mixture was stirred at 70°C for 4 hours, quenched with water (100 mL) and was extracted with ethyl acetate (100 mL×3). The combined organic layer was washed with saturated brine (100 mL), dried with anhydrous sodium sulfate, filtered and evaporated under reduced pressure to obtain a residue. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 50:1 to 20:1) to obtain BB-1B-4. MS-ESI (m/z): 283.9[M-55]+
With luitdine In tetrahydrofuran at 70℃; for 4h; 2.3 Step 3: Synthesis of compound BB-1B-4 The reactants BB-1B-3 (6 g) and Boc anhydride (15.16 g) were dissolved in tetrahydrofuran (100 mL), and N,N-lutidine (4.58 g) was added to form a mixture. The mixture was stirred at 70°C for 4 hours, quenched with water (100 mL) and was extracted with ethyl acetate (100 mL×3). The combined organic layer was washed with saturated brine (100 mL), dried with anhydrous sodium sulfate, filtered and evaporated under reduced pressure to obtain a residue. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 50:1 to 20:1) to obtain BB-1B-4. MS-ESI (m/z): 283.9[M-55]+
  • 2
  • 7-bromo-5-oxo-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>b</i>]azepine-4-carboxylic acid ethyl ester [ No CAS ]
  • [ 3951-89-1 ]
YieldReaction ConditionsOperation in experiment
21% With sulfuric acid; acetic acid at 90℃; for 2.5h;
  • 3
  • [ 3951-89-1 ]
  • [ 313724-44-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C
  • 4
  • [ 3951-89-1 ]
  • [ 313736-13-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 76 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 12 h / 20 °C
  • 5
  • [ 3951-89-1 ]
  • [ 313736-39-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 87 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C
  • 6
  • [ 3951-89-1 ]
  • 7-bromo-1-(3-methyl-butyl)-2,3-dihydro-1<i>H</i>-benzo[<i>b</i>]azepine-4-carbonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 87 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C 8: 91 percent / HCl / ethyl acetate / 20 °C 9: SOCl2; DMF / tetrahydrofuran / 20 °C
  • 7
  • [ 3951-89-1 ]
  • [ 313736-45-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 87 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C 8: 91 percent / HCl / ethyl acetate / 20 °C
  • 8
  • [ 3951-89-1 ]
  • [ 313724-37-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating
Multi-step reaction with 4 steps 1.1: luitdine / tetrahydrofuran / 4 h / 70 °C 2.1: sodium methoxide / 2 h / 100 °C / Inert atmosphere 3.1: sodium tetrahydridoborate; methanol / tetrahydrofuran / 0.5 h / -40 - -15 °C 4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere 4.2: 1 h / 20 °C / Inert atmosphere
  • 9
  • [ 3951-89-1 ]
  • 7-Bromo-5-hydroxy-2,3,4,5-tetrahydro-benzo[b]azepine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C
Multi-step reaction with 3 steps 1: luitdine / tetrahydrofuran / 4 h / 70 °C 2: sodium methoxide / 2 h / 100 °C / Inert atmosphere 3: sodium tetrahydridoborate; methanol / tetrahydrofuran / 0.5 h / -40 - -15 °C
  • 10
  • [ 3951-89-1 ]
  • [ 313724-31-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating
Multi-step reaction with 2 steps 1: luitdine / tetrahydrofuran / 4 h / 70 °C 2: sodium methoxide / 2 h / 100 °C / Inert atmosphere
  • 11
  • [ 3951-89-1 ]
  • 7-bromo-5-methanesulfonyloxy-2,3,4,5-tetrahydro-benzo[<i>b</i>]azepine-1,4-dicarboxylic acid 1-<i>tert</i>-butyl ester 4-methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C
  • 12
  • [ 3951-89-1 ]
  • [ 313724-71-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 82 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 7: 93 percent / aq. HCl / ethyl acetate / 80 °C
  • 13
  • [ 3951-89-1 ]
  • [ 313750-60-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating
Multi-step reaction with 6 steps 1.1: luitdine / tetrahydrofuran / 4 h / 70 °C 2.1: sodium methoxide / 2 h / 100 °C / Inert atmosphere 3.1: sodium tetrahydridoborate; methanol / tetrahydrofuran / 0.5 h / -40 - -15 °C 4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere 4.2: 1 h / 20 °C / Inert atmosphere 5.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / lithium hydroxide monohydrate; dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere 6.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C
  • 14
  • [ 3951-89-1 ]
  • [ 313727-06-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 82 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 7: 93 percent / aq. HCl / ethyl acetate / 80 °C 8: 97 percent / pyridine / tetrahydrofuran / 0.5 h / 20 °C
  • 15
  • [ 3951-89-1 ]
  • 1-acetyl-7-(4-morpholin-4-yl-phenyl)-2,3-dihydro-1<i>H</i>-benzo[<i>b</i>]azepine-4-carbonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 82 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 7: 93 percent / aq. HCl / ethyl acetate / 80 °C 8: 97 percent / pyridine / tetrahydrofuran / 0.5 h / 20 °C 9: 98 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C 10: SOCl2; DMF / tetrahydrofuran / 20 °C
  • 16
  • [ 3951-89-1 ]
  • [ 313727-12-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 82 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 7: 93 percent / aq. HCl / ethyl acetate / 80 °C 8: 97 percent / pyridine / tetrahydrofuran / 0.5 h / 20 °C 9: 98 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C
  • 17
  • [ 3951-89-1 ]
  • [ 597583-16-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 76 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 12 h / 20 °C 8: 62 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 9: 84 percent / aq. NaOH / tetrahydrofuran; methanol / 20 h / 20 °C 10: SOCl2; DMF / tetrahydrofuran / 20 °C
  • 18
  • [ 3951-89-1 ]
  • [ 313736-28-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 76 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 12 h / 20 °C 8: 62 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating
  • 19
  • [ 3951-89-1 ]
  • [ 313736-34-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 76 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 12 h / 20 °C 8: 62 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 9: 84 percent / aq. NaOH / tetrahydrofuran; methanol / 20 h / 20 °C
  • 20
  • [ 3951-89-1 ]
  • 7-[4-(2-butoxy-ethoxy)-phenyl]-1-cyclopropylmethyl-2,3-dihydro-1<i>H</i>-benzo[<i>b</i>]azepine-4-carbonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 100 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C 9: 96 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C 10: SOCl2; DMF / tetrahydrofuran / 20 °C
  • 21
  • [ 3951-89-1 ]
  • 7-[4-(2-butoxy-ethoxy)-phenyl]-1-phenyl-2,3-dihydro-1<i>H</i>-benzo[<i>b</i>]azepine-4-carbonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 71 percent / copper(II) pivalate / CH2Cl2 / 20 °C 9: 75 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C 10: SOCl2; DMF / tetrahydrofuran / 20 °C
  • 22
  • [ 3951-89-1 ]
  • [ 313729-65-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 100 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C
  • 23
  • [ 3951-89-1 ]
  • [ 313724-66-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 82 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating
  • 24
  • [ 3951-89-1 ]
  • [ 313730-21-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 71 percent / copper(II) pivalate / CH2Cl2 / 20 °C 9: 75 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C
  • 25
  • [ 3951-89-1 ]
  • [ 313730-15-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 71 percent / copper(II) pivalate / CH2Cl2 / 20 °C
  • 26
  • [ 3951-89-1 ]
  • [ 313729-70-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 100 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C 9: 96 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C
  • 27
  • [ 3951-89-1 ]
  • [ 719297-14-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 88 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C
  • 28
  • [ 3951-89-1 ]
  • [ 313729-45-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 100 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C
  • 29
  • [ 3951-89-1 ]
  • 7-[4-(2-butoxy-ethoxy)-phenyl]-1-thiazol-2-ylmethyl-2,3-dihydro-1<i>H</i>-benzo[<i>b</i>]azepine-4-carbonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 88 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C 9: 78 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C 10: SOCl2; DMF / tetrahydrofuran / 20 °C
  • 30
  • [ 3951-89-1 ]
  • [ 313751-90-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: DMAP / tetrahydrofuran / 1.5 h / Heating 2: 3.89 g / sodium methoxide / 2.5 h / Heating 3: NaBH4 / tetrahydrofuran; methanol / 1 h / -15 °C 4: Et3N / tetrahydrofuran / 14 h / 20 °C 5: 2.53 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / Heating 6: 100 percent / aq. HCl / ethyl acetate / 0.5 h / 80 °C 7: 56 percent / aq. K2CO3; Pd(PPh3)4 / toluene; ethanol / Heating 8: 88 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C 9: 78 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C
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7,9-Dibromo-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

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Ketones

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7,9-Dibromo-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

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8-Bromo-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

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